Neutrophils, interleukin-17A and lung disease

• It is now established that an excessive and sustained mobilisation of neutrophils is a hallmark of several chronic inflammatory lung disorders, including severe obstructive lung disease. This article reviews evidence that the cytokine interleukin (IL)-17A is a major orchestrator of sustained neutrophilic mobilisation. Current evidence suggests that IL-17A is produced by T-lymphocytes, and that it exerts an orchestrating effect on the accumulation and associated activity of neutrophils in the bronchoalveolar space indirectly, through an induced release of specific cytokines and colony-stimulating factors in resident lung cells. Although the involvement of IL-17A in inflammatory lung disorders is supported by several recent studies, its causative role is still uncertain. However, the unique position of interleukin-17A at the interface between acquired and innate immunity puts this cytokine forward as an important signal for the reinforcement of host defence; it also implies that interleukin-17A may constitute a useful target for pharmacotherapeutic intervention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

Biological Markers/blood

Cytokines/analysis/metabolism

Female

Humans

Immunity

Natural/*physiology

Interleukin-17/*immunology/metabolism

Lung Diseases/*immunology/*physiopathology

Lymphocyte Activation

Male

Neutrophils/*immunology/metabolism

Prognosis

Risk Factors

Sensitivity and Specificity

Severity of Illness Index

T-Lymphocytes/*immunology/metabolism

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)