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Träfflista för sökning "WFRF:(Lagercrantz H) srt2:(1989)"

Sökning: WFRF:(Lagercrantz H) > (1989)

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1.
  • Milerad, J, et al. (författare)
  • Respiratory and arousal responses to hypoxia in apnoeic infants reinvestigated.
  • 1989
  • Ingår i: European journal of pediatrics. - 0340-6199. ; 148:6, s. 565-70
  • Tidskriftsartikel (refereegranskat)abstract
    • Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE). Respiratory movements and transcutaneous gas pressures (tcPO2 and tcPCO2) were continuously monitored during the 10 min test. The changes in tcPCO2 in relation to the decrease in tcPO2 were used as an index of the ventilatory and metabolic responses to hypoxia. We found that the response of apnoeic infants was within the range of the controls although the distribution of the individual response slopes was shifted towards the lower end of the range. Arousal was observed in 33% of apnoeic infants and 32% of the controls. Regular periodic breathing occurred in 42% of apnoeic infants compared to 28% of controls. In contrast to the controls, periodic breathing in apnoeic infants was not associated with a drop in tcPCO2 to below baseline levels. Apnoeic infants also alternated between regular and periodic breathing during the test. These findings are suggestive of a weak feed back control of breathing but do not support former views of a deficient hypoxic response in infants with ALTE.
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2.
  • Wennergren, Göran, 1947, et al. (författare)
  • Hypoxia reinforces laryngeal reflex bradycardia in infants.
  • 1989
  • Ingår i: Acta paediatrica Scandinavica. - 0001-656X. ; 78:1, s. 11-7
  • Tidskriftsartikel (refereegranskat)abstract
    • The laryngeal chemoreflex involves bradycardia, apnea, swallowing and peripheral vasoconstriction. This reflex was studied in twelve infants, aged 5 days-28 weeks, who had sustained an apparent life-threatening event or were siblings of infants who had died of the sudden infant death syndrome. The bradycardic and apneic components of the reflex were found to be significantly, and sometimes powerfully, reinforced when elicited by pharyngeal water instillation during acute, mild hypoxia (transcutaneous PO2 4.6-8.3 kPa). Apnea duration during normoxia was 0.7-15 sec, and during hypoxia 2-30 sec. Heart rate change ranged from +26% to -21% during normoxia, as compared with -4% to -63% during hypoxia. The percentage change in heart rate was found to inversely correlate with the transcutaneous PO2-level prevailing when the reflex was elicited. The conclusion is that there is a significant reinforcement of the cardiorespiratory adjustments when the laryngeal reflex is activated during simultaneous excitation of the peripheral arterial chemoreceptors. One infant, showing a particularly strong increase of the cardiorespiratory response to laryngeal receptor stimulation during hypoxia, later died of sudden infant death syndrome.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Wennergren, Göran, 1 ... (2)
Lagercrantz, H (2)
Milerad, J (2)
HERTZBERG, T (2)
Bjure, Jan (1)
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Göteborgs universitet (2)
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Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
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1989 (2)Ta bort avgränsningen

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