| 1. |
- Macleod, Malcolm R, et al.
(författare)
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Mineralocorticoid receptor expression and increased survival following neuronal injury
- 2003
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Ingår i: European Journal of Neuroscience. - : Wiley. - 0953-816X .- 1460-9568. ; 17:8, s. 1549-1555
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Tidskriftsartikel (refereegranskat)abstract
- Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown. Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia. In both the cell culture system and the in vivo system increased mineralocorticoid receptor expression is associated with increased neuronal survival, and this increase is reversed by mineralocorticoid receptor antagonism. Modulation of mineralocorticoid receptor gene expression may therefore be an important target for reduction of brain injury in conditions caused by cerebral ischaemia including brain damage following cardiac arrest and stroke.
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| 2. |
- Martinez, D. M., et al.
(författare)
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Dryness and physical properties of paper webs in laboratory-scale impulse processing
- 2001
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Ingår i: Drying Technology. - 0737-3937 .- 1532-2300. ; 19:10, s. 2435-2450
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Tidskriftsartikel (refereegranskat)abstract
- This investigation evaluates the changes in dryness and physical properties of impulse processed paper webs. A laboratory-scale platen press was used to process 60 g/m2 webs under a wide range of pressure impulses and temperatures (23-380°C). The heat transfer rate to the web was also varied by using two different platen materials (steel and copper). Both thermomechanical and bleached kraft pulps were tested, and the dryness, density, surface roughness, and Scott bond were measured for each trial. Results show that dewatering is enhanced with increased temperature, pressure, and nip residence time, while pressure pulse shape and platen material have little influence. An empirical correlation is given to relate sheet dryness to the key process variables. This correlation suggests that resulting dryness values are not unique; that is, different combinations of temperature, pressure, and nip residence time can be used to obtain a similar level of dryness. Physical reasoning was used to develop a second correlation that links the resulting dryness to the density of the completely dried web. Surface roughness decreased with increasing surface temperature, while Scott bond rose sharply under conditions of high temperature and long nip residence time.
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| 3. |
- Scherer, SW, et al.
(författare)
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Human chromosome 7: DNA sequence and biology
- 2003
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
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Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
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| 4. |
- Yang, HW, et al.
(författare)
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Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis : frequency in pure cultured isolates
- 2004
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Ingår i: Journal of Periodontology. - : Wiley. - 0022-3492 .- 1943-3670. ; 75:4, s. 592-599
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: To our knowledge, the association of the five serotypes of Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) to the new diagnostic classification scheme defined by the American Academy of Periodontology in 1999 has not yet been described. The goal of this study was to characterize the frequencies of the five serotypes of A. actinomycetemcomitans in A. actinomycetemcomitans isolates from various forms of periodontitis using both old and new diagnostic classifications and to determine the relationships between serotype and age and clinical diagnosis. METHODS: A total of 345 A. actinomycetemcomitans isolates from 115 A. actinomycetemcomitans culture-positive subjects (mean age 38.0 +/- 18.3 years, 59% female) were collected. Based on the new classifications, 33 subjects had aggressive periodontitis and 82 chronic periodontitis. According to old classifications, there were six prepubertal periodontitis (PPP), 12 localized juvenile periodontitis (LJP), 15 post-localized juvenile periodontitis (PLJP), 28 refractory periodontitis (Ref-P), and 54 adult periodontitis (AP) cases. Serotypes of A. actinomycetemcomitans were determined by an indirect immunofluorescence assay using serotype-specific polyclonal antisera to A. actinomycetemcomitans strains ATCC 29523, ATCC 43728, ATCC 33384, IDH 781 and IDH 1705 (serotype a, b, c, d, and e, respectively). Proportions of serotype b were examined between different diagnostic and age groups with a Z-test for proportions. RESULTS: Most subjects (n = 100, 86.96%) were infected with a single serotype (22 serotype a, 44 serotype b, 30 serotype c, 1 serotype d, and 3 serotype e). There were 11 subjects (9.57%) with two serotypes and two subjects (1.74%) with 3 serotypes. Two individuals had isolates lacking any detectable serotype antigen. Serotype b was the predominant serotype in children under 18 years of age and young adults between 19 to 35 years, although serotype b status was not significantly associated with age. Serotypes d and e were not found in patients under 35 years old. In 62 adult patients, one subject had serotype d and three had serotype e. Serotype b was the most common serotype in aggressive periodontitis (60.61%). The proportion of cases with serotype b was significantly higher in aggressive periodontitis compared to chronic periodontitis (P = 0.031). Other serotypes were not significantly associated with new diagnostic categories. Serotypes d and e were not detected in aggressive periodontitis. CONCLUSION: The results of this study show that proportions of serotype b of A. actinomycetemcomitans are significantly greater in culture-positive patients with aggressive periodontitis than those with chronic periodontitis.
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