| 1. |
- Butt, Salma, et al.
(författare)
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Breastfeeding in relation to risk of different breast cancer characteristics.
- 2014
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Ingår i: BMC Research Notes. - : Springer Science and Business Media LLC. - 1756-0500. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this present study was to examine duration of breastfeeding in relation to the risk of different subgroups of breast cancer. A prospective cohort, The Malmö Diet and Cancer study, including 14092 parous women, were followed during a mean of 10.2 years and a total of 424 incident breast cancers were diagnosed.
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| 2. |
- Butt, Salma, et al.
(författare)
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Genetic predisposition, parity, age at first childbirth and risk for breast cancer.
- 2012
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Ingår i: BMC Research Notes. - : Springer Science and Business Media LLC. - 1756-0500. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk.METHODS: The Malmö Diet and Cancer Study (MDCS) included 17 035 female participants, from which 728 incident breast cancer cases were matched to 1448 controls. The associations between 14 SNPs and breast cancer risk were investigated in different strata of parity and age at first childbirth. A logistic regression analysis for the per allele risk, adjusted for potential confounders yielded odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Six of the previously identified SNPs showed a statistically significant association with breast cancer risk: rs2981582 (FGFR2), rs3803662 (TNRC9), rs12443621 (TNRC9), rs889312 (MAP3K1), rs3817198 (LSP1) and rs2107425 (H19). We could not find any statistically significant interaction between the effects of tested SNPs and parity/age at first childbirth on breast cancer risk after adjusting for multiple comparisons.CONCLUSIONS: The results of this study are in agreement with previous studies of null interactions between tested SNPs and parity/age at first childbirth with regard to breast cancer risk.
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| 3. |
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| 4. |
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| 5. |
- Isern, A E, et al.
(författare)
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Risk of recurrence following delayed large flap reconstruction after mastectomy for breast cancer.
- 2011
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 98, s. 659-666
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast reconstruction. Matching criteria were year of diagnosis, age at diagnosis and treating hospital. Medical records were evaluated until October 2007. Histopathological specimens for all included women were re-evaluated. The endpoint was locoregional or distant breast cancer recurrence. The risk of recurrent disease was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. RESULTS: Median follow-up for the entire cohort was 146 months. The reconstruction group had a 2·08 (95 per cent confidence interval 1·07 to 4·06) times higher risk of recurrent disease than the mastectomy only group. CONCLUSION: Women with breast cancer who had delayed reconstruction with a large flap in this study had a higher risk of recurrent disease than those with mastectomy alone. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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| 6. |
- Landberg, Jonas, et al.
(författare)
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Alcohol and homicide in Russia and the United States – a comparative analysis
- 2011
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Ingår i: Journal of Studies on Alcohol and Drugs. - 1937-1888 .- 1938-4114. ; 72:5, s. 723-730
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The object of this study was to perform a comparative analysis of the aggregate relationship between alcohol and homicide in Russia and in the United States. The comparison was based on the magnitude of the alcohol effect, the alcohol attributable fraction (AAF), and the degree to which total consumption could account for trends in homicide. Method: We analyzed total and sex-specific homicide rates for the age groups 15-64 years, 15-34 years, and 35-64 years. The study period was 1959-1998 for Russia and 1950-2002 for the United States. For the United States, alcohol consumption was gauged by sales of alcohol; for Russia, estimated unrecorded consumption was included as well. The data were analyzed through autoregressive integrated moving average (ARIMA) modeling. Results: The results show that, for Russia as well as for the United States, a 1-L increase in consumption was associated with an increase in homicides of about 10%, although the absolute effect was markedly larger in Russia because of differences in homicide rates. The AAF estimates suggested that 73% and 57% of the homicides would be attributable to alcohol in Russia and in the United States, respectively. Most of the temporal variation in the Russian homicide rate could be accounted for by the trend in drinking, whereas the U.S. trend in total alcohol consumption had a more limited ability to predict the trend in homicides. Conclusions: We conclude that the role of alcohol in homicide seems to be larger in Russia than in the United States.
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| 7. |
- Landberg, Jonas, 1974-
(författare)
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Alcohol-Related Problems in Eastern Europe : A Comparative Perspective
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis investigates the association between alcohol consumption and alcohol-related harm in Eastern Europe. The main aim was to estimate to what extent changes in per capita alcohol consumption have an impact on different forms of alcohol-related mortality, and to put the results in an international comparative perspective. The thesis includes four papers; the first two papers use aggregate time-series analysis to assess how changes in per capita consumption affect rates in suicide mortality and fatal non-intentional injuries in several Eastern European countries, respectively. The third paper applies the same methodological approach to analyse the population-level relationship between alcohol and homicide in Russia and the U.S.. The fourth paper employs survey data to assess how the risk of experiencing alcohol-related problems in relation to volume of consumption in the Baltic countries compares to Sweden and Italy. The results of the first three papers suggests: (i) that changes in per capita consumption are significantly related to changes in mortality rates of suicide, non-intentional injuries and homicide in the countries under study; (ii) that the relationship is stronger for men than for women, and (iii) that the relationship tends to be stronger in the countries with more detrimental drinking patterns, e.g. Russia. The results of the fourth paper suggest that the risk of experiencing alcohol-related problems in relation to level of drinking in the Baltic countries is similar to the corresponding risk in Sweden, but considerably stronger than in Italy. In conclusion, the findings support the significance of a public health approach to alcohol-related problems in Eastern Europe, i.e., policy measures directed towards total alcohol consumption. In addition, strategies aimed at reducing the occurrence of binge drinking seem to have great potential for reducing alcohol-related harm and mortality in Eastern European countries.
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| 8. |
- Landberg, Jonas, et al.
(författare)
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Changes in the Relationship Between Volume of Consumption and Alcohol-Related Problems in Sweden During 1979-2003
- 2014
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Ingår i: Alcohol and Alcoholism. - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 49:3, s. 308-316
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of the study was to investigate (i) whether the strength of the relationship between self-reported volume of consumption and alcohol-related problems has become weaker in Sweden, and (ii) whether such a change can be related to temporal changes in drinking patterns or to changes in the distribution of consumption and related problems in the population. Methods: Three cross-sectional general population surveys conducted in Sweden in 1979, 1995 and 2003 yielded data on 5650 Swedish adults aged 18-69 years. The relationship between self-reported volume of consumption and self-reported alcohol-related problems was estimated using Poisson regression models. Analyses of drinking patterns focused on changes in frequency of drinking, volume per occasion and frequency of drinking to intoxication. Lorenz curves were used to analyse the distributions of consumption and alcohol-related problems. Results: Poisson regression estimates revealed that the relationship between volume of consumption and alcohol-related problems became weaker over time; a 10% per cent change in self-reported volume of consumption was associated with a smaller per cent change in the number of experienced problems in 2003 (5%) compared with 1995 (6%) and 1979 (7%). This change was not related to a hypothesized general shift towards a more southern European style of drinking, as no such tendency was found. Conclusion: The changed relationship appears to be a reflection of a redistribution of consumption and alcohol-related problems in the population, such that a larger share of all consumption and related problems occurs among light or moderate drinkers in 2003 compared with 1979.
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| 9. |
- Landberg, Jonas
(författare)
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Effects of the transition to beverages with lighter alcohol content in Sweden 1950-2001
- 2011
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Ingår i: Contemporary Drug Problems. - 0091-4509 .- 2163-1808. ; 38:4, s. 541-
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article was to study whether the transition to lighter beverages in Sweden has been associated with a decrease in alcohol-related harm. The analyses were based on Swedish aggregate time-series data on alcohol consumption and different forms of alcohol-related mortality for the period 1950-2001. A descriptive trend comparison revealed that, since the 1970s, the mortality rates per liter for most studied outcomes followed the trend in proportion of spirits fairly well. Time-series model estimations only partially supported this picture: Beverage-specific models revealed that, of all beverages, spirits was significantly related to most different forms of mortality, but in models that included proportion of spirits (controlling for total consumption), the association was only significant for male liver cirrhosis. In conclusion, the findings do not support the idea that the composition of beverages in the total composition has an independent effect on alcohol-related harm. However; because per capita consumption of spirits was significantly related to more forms of mortality than beet" or wine, we cannot rule out alcohol policy measures directed towards the consumption of stronger beverages as being noneffective in terms of reducing alcohol-related harm.
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| 10. |
- Landberg, Jonas, 1974-
(författare)
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Population drinking and fatal injuries in Eastern Europe : A time-series analysis of six countries
- 2010
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Ingår i: European Addiction Research. - : S. Karger AG. - 1022-6877 .- 1421-9891. ; 16:1, s. 43-52
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To estimate to what extent injury mortality rates in 6 Eastern European countries are affected by changes in population drinking during the post-war period. Data and Methods: The analysis included injury mortality rates and per capita alcohol consumption in Russia, Belarus, Poland, Hungary, Bulgaria and the former Czechoslovakia. Total population and gender-specific models were estimated using auto regressive integrated moving average time-series modelling. Results: The estimates for the total population were generally positive and significant. For Russia and Belarus, a 1-litre increase in per capita consumption was associated with an increase in injury mortality of 7.5 and 5.5 per 100,000 inhabitants, respectively. The estimates for the remaining countries ranged between 1.4 and 2.0. The gender-specific estimates displayed national variations similar to the total population estimates although the estimates for males were higher than for females in all countries. Conclusions: The results suggest that changes in per capita consumption have a significant impact on injury mortality in these countries, but the strength of the association tends to be stronger in countries where intoxication-oriented drinking is more common.
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