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| 2. |
- Machiela, Mitchell J., et al.
(författare)
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Characterization of Large Structural Genetic Mosaicism in Human Autosomes
- 2015
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 96:3, s. 487-497
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Tidskriftsartikel (refereegranskat)abstract
- Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
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| 3. |
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Kommunen i EU
- 2018
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Ingår i: Statsvetenskaplig tidskrift. - 0039-0747. ; 120:5, s. 5-163
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Annan publikation (refereegranskat)abstract
- Särskild utgåva av Statsvetenskaplig tidskrift, på temat Kommunen i EU, med bidrag från forskare i både statsvetenskap och juridik, samt kommentarer av praktiker.
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| 4. |
- Landgren, Kajsa, et al.
(författare)
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Ear Acupuncture in Psychiatric Care From the Health Care Professionals' Perspective : A Phenomenographic Analysis
- 2019
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Ingår i: Issues in Mental Health Nursing. - : Informa UK Limited. - 1096-4673 .- 0161-2840. ; 40:2, s. 166-175
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Tidskriftsartikel (refereegranskat)abstract
- Ear acupuncture is used as a non-pharmacological complement in psychiatric and addiction care to reduce anxiety, depression and insomnia. The aim of this study was to describe health care professionals' perceptions of giving ear acupuncture in different psychiatric settings. Twenty-four professionals providing ear acupuncture to patients with a variety of psychiatric symptoms and/or addiction were interviewed in focus groups. Data were analyzed with a phenomenographic approach. Ear acupuncture was provided, individually or in groups, to in- and outpatients with a variety of psychiatric symptoms and/or addiction. Three descriptive categories emerged: Another tool in the toolbox, Strengthening the profession and Person-centered care. Participants perceived ear acupuncture to be an effective and safe therapeutic tool, easy to use in concert with other methods and easy to adjust to the patients' needs and requests. They perceived that their professional self-confidence increased when having this non-verbal, person-centered and non-pharmacological tool in their hands as a complement to ordinary care. Professionals perceived that patients trained their social skills while participating in acupuncture, and that the treatment helped patients to influence their subjective psychiatric health through gaining control over symptoms. Acupuncture helped professionals to build a trustful relationship and communicate with their patients, verbally and non-verbally. The finding shows ear acupuncture as a safe treatment and promising in relieving psychiatric and somatic symptoms. Acupuncture facilitates the communication with patient, emphasizing participation and shared decision-making, valuable dimensions of person-centered care. Managers' role and attitude in supporting staff needs to be explored in future research.
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| 6. |
- Montin, Stig, 1954, et al.
(författare)
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Inledning: Kommunen i EU
- 2018
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Ingår i: Statsvetenskaplig Tidsskrift. - 0039-0747. ; 120:5, s. 5-12
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Wise, Emily, et al.
(författare)
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Evaluating the Role of HEIs´Interaction with Surrounding Society : Developmental Pilot in Sweden 2013-2016
- 2016
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Rapport (populärvet., debatt m.m.)abstract
- Driven by increased expectations on the use of knowledge to benefit sustainable social development and growth, the government’s research and innovation bill in 2012 highlighted the need to develop new incentives and structures to foster universities’ interaction with surrounding society. Following this, the government assigned Vinnova the task of developing methods and criteria for assessing the performance and quality of universities’ societal interaction.In responding to the government assignment, Vinnova’s ultimate aim was to strengthen the quality and relevance of research and education through developing the societal interaction of HEIs and in turn bolstering Swedish HEIs’ attractiveness and competitiveness globally. Thus, our focus was not on creating metrics, but rather on designing an approach to incentivize HEI’s own continual development of their interaction with surrounding society.But how to influence such a development process in a meaningful way, especially given Sweden’s diverse HEI landscape? Our answer was to devise a model for evaluation of societal interaction through a collaborative process together with Swedish HEIs and other stakeholders.Starting in 2013, Vinnova has led an inclusive and interactive process to develop a model for evaluating HEIs’ interaction with society. The process has leveraged external knowledge, international expertise, and most importantly actively involved 27 Swedish HEIs. As we near the end of our government assignment and look back, we take the opportunity to reflect on the process and its results – what worked well or less well? What did we achieve? What did we learn? What is still left to do?This document tells this story – or at least the first part of the story, as the process has only just begun. It is not an academic paper or technical report, but rather an account of the last four years – including the facts, some illustrative examples of HEI activities, and reflections on the process and its results.
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