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Clonal haematopoies...
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias
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- Schuermans, Art (författare)
- Massachusetts General Hospital,Broad Institute
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Vlasschaert, Caitlyn (författare)
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- Nauffal, Victor (författare)
- Brigham and Women's Hospital / Harvard Medical School,Broad Institute
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- Cho, So Mi Jemma (författare)
- Yonsei University,Massachusetts General Hospital,Broad Institute
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- Uddin, Md Mesbah (författare)
- Massachusetts General Hospital,Broad Institute
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- Nakao, Tetsushi (författare)
- Dana-Farber Cancer Institute,Broad Institute,Massachusetts General Hospital,Brigham and Women's Hospital / Harvard Medical School
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- Niroula, Abhishek (författare)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Dana-Farber Cancer Institute,Broad Institute
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- Klarqvist, Marcus D.R. (författare)
- Broad Institute
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- Weeks, Lachelle D. (författare)
- Dana-Farber Cancer Institute
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- Lin, Amy E. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute
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- Saadatagah, Seyedmohammad (författare)
- Baylor College of Medicine
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- Lannery, Kim (författare)
- Massachusetts General Hospital,Broad Institute
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- Wong, Megan (författare)
- Massachusetts General Hospital,Broad Institute
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- Hornsby, Whitney (författare)
- Massachusetts General Hospital,Broad Institute
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- Lubitz, Steven A. (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Ballantyne, Christie (författare)
- Baylor College of Medicine
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- Jaiswal, Siddhartha (författare)
- Stanford University School of Medicine
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- Libby, Peter (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Ebert, Benjamin L. (författare)
- Dana-Farber Cancer Institute,Harvard Medical School,Howard Hughes Medical Institute
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- Bick, Alexander G. (författare)
- Vanderbilt University Medical Center
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- Ellinor, Patrick T. (författare)
- Massachusetts General Hospital,Harvard Medical School,Broad Institute
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- Natarajan, Pradeep (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Honigberg, Michael C. (författare)
- Massachusetts General Hospital,Harvard Medical School,Broad Institute
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(creator_code:org_t)
- 2024
- 2024
- Engelska 15 s.
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Ingår i: European Heart Journal. - 0195-668X. ; 45:10, s. 791-805
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested. Results This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04–1.18; P = .001] and 1.13 (95% CI 1.05–1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01–1.19; P = .031) and 1.13 (95% CI 1.03–1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00–1.34; P = .049) and 1.22 (95% CI 1.03–1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07–1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR. Conclusions CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aging
- Arrhythmia
- Atrial fibrillation
- Cardiac arrest
- Genomics
- Prevention
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Schuermans, Art
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Vlasschaert, Cai ...
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Nauffal, Victor
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Cho, So Mi Jemma
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Uddin, Md Mesbah
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Nakao, Tetsushi
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Niroula, Abhishe ...
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Klarqvist, Marcu ...
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Weeks, Lachelle ...
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Lin, Amy E.
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Saadatagah, Seye ...
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Lannery, Kim
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Wong, Megan
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Hornsby, Whitney
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Lubitz, Steven A ...
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Ballantyne, Chri ...
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Jaiswal, Siddhar ...
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Libby, Peter
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Ebert, Benjamin ...
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Bick, Alexander ...
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Ellinor, Patrick ...
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Natarajan, Prade ...
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Honigberg, Micha ...
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European Heart J ...
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