The relations of microalbuminuria to ambulatory blood pressure and myocardial wall thickness in a population.

• To examine the relationship between microalbuminuria (20-200 microg min(-1)) and 24 h ambulatory blood pressure and heart wall thickness, in a representative population sample of men and women aged 56-65 years.Every second individual aged 56-65 years (n=488) in the district, was invited for a health examination, which included determination of urinary albumin and creatinine (overnight sample). The highest and lowest decentile of urinary albumin/creatinine ratio were compared.The district of the Primary Health Care and Research Centre of Mölnlycke, Sweden.After excluding 2 individuals with a urinary albumin excretion exceeding 200 microg min(-1). 26 subjects (group 1) could be compared with 27 subjects in the lowest decentile (group 2).Comparison between the determinations of the ambulatory blood pressure and echocardiographic variables in the two groups.Group 1 had significantly higher 24 h ambulatory blood pressure, and heart septum and posterior wall thickness as well as significantly higher fasting blood glucose and serum triglyceride concentrations. The differences in blood pressure (P < 0.05) but not heart wall thickness remained significant (P<0.05) after excluding subjects with hypertension, angina pectoris, treated diabetes mellitus, and/or history of heart or cerebrovascular disease. When excluding individuals with both treated and untreated diabetes mellitus, fasting blood glucose concentration was higher in group 1. The waist-hip ratio, weight and body mass index did not differ between the groups.The findings indicate that microalbuminuria is related to signs of cardiovascular and metabolic influence and therefore could be a valuable tool for grading the risk of later cardiovascular morbidity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Aged

Albuminuria

classification

complications

metabolism

Blood Glucose

Blood Pressure

Body Mass Index

Cardiovascular Diseases

etiology

Creatinine

urine

Echocardiography

Female

Humans

Male

Middle Aged

Myocardium

pathology

Population Surveillance

methods

Risk Factors

Sweden

Triglycerides

blood

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)