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Gut microbiota dysb...
Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modeling
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- Kumar, Manish, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ji, Boyang, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Babaei, Parizad, 1990 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Das, Promi, 1990 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lappa, Dimitra, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ramakrishnan, G. (författare)
- University of Virginia
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- Fox, T. E. (författare)
- University of Virginia
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- Haque, R. (författare)
- International Centre for Diarrhoeal Disease Research Bangladesh
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- Petri, W. A. (författare)
- University of Virginia
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- Bäckhed, Fredrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Köpenhamns universitet,University of Copenhagen,University of Gothenburg
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- Nielsen, Jens B, 1962 (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Metabolic Engineering. - : Elsevier BV. - 1096-7176 .- 1096-7184. ; 49, s. 128-142
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Malnutrition is a severe non-communicable disease, which is prevalent in children from low-income countries. Recently, a number of metagenomics studies have illustrated associations between the altered gut microbiota and child malnutrition. However, these studies did not examine metabolic functions and interactions between individual species in the gut microbiota during health and malnutrition. Here, we applied genome-scale metabolic modeling to model the gut microbial species, which were selected from healthy and malnourished children from three countries. Our analysis showed reduced metabolite production capabilities in children from two lowincome countries compared with a high-income country. Additionally, the models were also used to predict the community-level metabolic potentials of gut microbes and the patterns of pairwise interactions among species. Hereby we found that due to bacterial interactions there may be reduced production of certain amino acids in malnourished children compared with healthy children from the same communities. To gain insight into alterations in the metabolism of malnourished (stunted) children, we also performed targeted plasma metabolic profiling in the first 2 years of life of 25 healthy and 25 stunted children. Plasma metabolic profiling further revealed that stunted children had reduced plasma levels of essential amino acids compared to healthy controls. Our analyses provide a framework for future efforts towards further characterization of gut microbial metabolic capabilities and their contribution to malnutrition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Övrig annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Other Medical and Health Sciences not elsewhere specified (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Child malnutrition
- Gut microbiota
- Genome-scale metabolic modeling
- Bacterial interactions
- breast-milk
- global reconstruction
- fatty-acids
- in-silico
- growth
- tryptophan
- brain
- interventions
- children
- life
- Biotechnology & Applied Microbiology
- nphaic.v
- 1973
- journal of biological chemistry
- v248
- p2176
- ates of america
- v104
- p1777
- ates of america
- v107
- p19961
- wey kg
- 1995
- journal of pediatrics
- v126
- p696
- ates of america
- v106
- p3698
- Bacterial interactions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kumar, Manish, 1 ...
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Ji, Boyang, 1983
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Babaei, Parizad, ...
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Das, Promi, 1990
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Lappa, Dimitra, ...
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Ramakrishnan, G.
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visa fler...
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Fox, T. E.
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Haque, R.
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Petri, W. A.
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Bäckhed, Fredrik ...
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Nielsen, Jens B, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Övrig annan medi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Metabolic Engine ...
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola