| 1. |
- Perez-Nadales, Elena, et al.
(författare)
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Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales : The impact of cytomegalovirus disease and lymphopenia
- 2020
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Ingår i: American Journal of Transplantation. - : WILEY. - 1600-6135 .- 1600-6143. ; 20:6, s. 1629-1641
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Tidskriftsartikel (refereegranskat)abstract
- Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score >= 8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score >= 8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
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| 2. |
- Worley, C. C., et al.
(författare)
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The Gaia-ESO Survey : Spectroscopic-asteroseismic analysis of K2 stars in Gaia-ESO The K2 Galactic Caps Project
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 643
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Tidskriftsartikel (refereegranskat)abstract
- Context. The extensive stellar spectroscopic datasets that are available for studies in Galactic Archeaology thanks to, for example, the Gaia-ESO Survey, now benefit from having a significant number of targets that overlap with asteroseismology projects such as Kepler, K2, and CoRoT. Combining the measurements from spectroscopy and asteroseismology allows us to attain greater accuracy with regard to the stellar parameters needed to characterise the stellar populations of the Milky Way.Aims. The aim of this Gaia-ESO Survey special project is to produce a catalogue of self-consistent stellar parameters by combining measurements from high-resolution spectroscopy and precision asteroseismology.Methods. We carried out an iterative analysis of 90 K2@Gaia-ESO red giants. The spectroscopic values of Teff were used as input in the seismic analysis to obtain log g values. The seismic estimates of log g were then used to re-determine the spectroscopic values of Teff and [Fe/H]. Only one iteration was required to obtain parameters that are in good agreement for both methods and, thus, to obtain the final stellar parameters. A detailed analysis of outliers was carried out to ensure a robust determination of the parameters. The results were then combined with Gaia DR2 data to compare the seismic log g with a parallax-based log g and to investigate instances of variations in the velocity and possible binaries within the dataset.Results. This analysis produced a high-quality catalogue of stellar parameters for 90 red giant stars from K2@Gaia-ESO that were determined through iterations between spectroscopy and asteroseismology. We compared the seismic gravities with those based on Gaia parallaxes to find an offset which is similar to other studies that have used asteroseismology. Our catalogue also includes spectroscopic chemical abundances and radial velocities, as well as indicators for possible binary detections.
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| 3. |
- Arentsen, A., et al.
(författare)
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The Pristine Inner Galaxy Survey (PIGS) I : tracing the kinematics of metal-poor stars in the Galactic bulge
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3925 .- 1745-3933. ; 491:1, s. L11-L16
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Tidskriftsartikel (refereegranskat)abstract
- Our Galaxy is known to contain a central boxy/peanut-shaped bulge, yet the importance of a classical, pressure-supported component within the central part of the Milky Way is still being debated. It should be most visible at low metallicity, a regime that has not yet been studied in detail. Using metallicity-sensitive narrow-band photometry, the Pristine Inner Galaxy Survey (PIGS) has collected a large sample of metal-poor ([Fe/H] < -1.0) stars in the inner Galaxy to address this open question. We use PIGS to trace the metal-poor inner Galaxy kinematics as function of metallicity for the first time. We find that the rotational signal decreases with decreasing [Fe/H], until it becomes negligible for the most metal-poor stars. Additionally, the velocity dispersion increases with decreasing metallicity for -3.0 < [Fe/II] < -0.5, with a gradient of -44 +/- 41un s(-1)dex(-1). These observations may signal a transition between Galactic components of different metallicities and kinematics, a different mapping on to the boxy/peanut-shaped bulge for former disc stars of different metallicities and/or the secular dynamical and gravitational influence of the bar on the pressure-supported component. Our results provide strong constraints on models that attempt to explain the properties of the inner Galaxy.
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| 4. |
- Cabrera-Ziri, I., et al.
(författare)
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Searching for globular cluster chemical anomalies on the main sequence of a young massive cluster
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 495:1, s. 375-382
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Tidskriftsartikel (refereegranskat)abstract
- The spectroscopic and photometric signals of the star-to-star abundance variations found in globular clusters seem to be correlated with global parameters like the cluster's metallicity, mass, and age. Understanding this behaviour could bring us closer to the origin of these intriguing abundance spreads. In this work we use deep HST photometry to look for evidence of abundance variations in the main sequence of a young massive cluster NGC 419 (similar to 10(5) M-circle dot, similar to 1.4 Gyr). Unlike previous studies, here we focus on stars in the same mass range found in old globulars (similar to 0.75-1 M-circle dot), where light elements variations are detected. We find no evidence for N abundance variations among these stars in the Un - B and U - B colour-magnitude diagrams of NGC 419. This is at odds with the N variations found in old globulars like 47 Tuc, NGC 6352, and NGC 6637 with similar metallicity to NGC 419. Although the signature of the abundance variations characteristic of old globulars appears to be significantly smaller or absent in this young cluster, we cannot conclude if this effect is mainly driven by its age or its mass.
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| 5. |
- Martocchia, S., et al.
(författare)
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Leveraging HST with MUSE : II. Na-abundance variations in intermediate age star clusters
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 499:1, s. 1200-1211
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Tidskriftsartikel (refereegranskat)abstract
- Ancient (>10 Gyr) globular clusters (GCs) show chemical abundance variations in the form of patterns among certain elements, e.g. N correlates with Na and anticorrelates with O. Recently, N abundance spreads have also been observed in massive star clusters that are significantly younger than old GCs, down to an age of similar to 2Gyr. However, so far N has been the only element found to vary in such young objects. We report here the presence of Na abundance variations in the intermediate age massive star clusters NGC 416 (similar to 6.5Gyr old) and Lindsay 1 (similar to 7.5Gyr old) in the Small Magellanic Cloud, by combining Hubble Space Telescope (HST) and European Southern Observatory Very Large Telescope MUSE observations. Using HST photometry, we were able to construct 'chromosome maps' and separate subpopulations with different N content, in the red giant branch of each cluster. MUSE spectra of individual stars belonging to each population were combined, resulting in high signal-to-noise spectra representative of each population, which were compared to search for mean differences in Na. We find a mean abundance variation of Delta[Na/Fe] = 0.18 +/- 0.04 dex for NGC 416 and Delta[Na/Fe] = 0.24 +/- 0.05 dex for Lindsay 1. In both clusters, we find that the population that is enhanced in N is also enhanced in Na, which is the same pattern to the one observed in ancient GCs. Furthermore, we detect a bimodal distribution of core-helium-burning red clump (RC) giants in the UV colour-magnitude diagram of NGC 416. A comparison of the stacked MUSE spectra of the two RCs shows the same mean Na abundance difference between the two populations. The results reported in this work are a crucial hint that star clusters of a large age range share the same origin: they are the same types of objects, but only separated in age.
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| 6. |
- Saracino, S., et al.
(författare)
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Leveraging HST with MUSE - I. Sodium abundance variations within the 2-Gyr-old cluster NGC 1978
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 498:3, s. 4472-4480
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Tidskriftsartikel (refereegranskat)abstract
- Nearly all of the well-studied ancient globular clusters (GCs), in the Milky Way and in nearby galaxies, show star-to-star variations in specific elements (e.g. He, C, N, O, Na, and Al), known as 'multiple populations' (MPs). However, MPs are not restricted to ancient clusters, with massive clusters down to similar to 2 Gyr showing signs of chemical variations. This suggests that young and old clusters share the same formation mechanism but most of the work to date on younger clusters has focused on N variations. Initial studies even suggested that younger clusters may not host spreads in other elements beyond N (e.g. Na), calling into question whether these abundance variations share the same origin as in the older GCs. In this work, we combine Hubble Space Telescope (HST) photometry with Very Large Telescope (VLT)/Multi-Unit Spectroscopic Explorer (MUSE) spectroscopy of a large sample of red giant branch (RGB) stars (338) in the Large Magellanic Cloud cluster NGC 1978, the youngest globular to date with reported MPs in the form of N spreads. By combining the spectra of individual RGB stars into N-normal and N-enhanced samples, based on the 'chromosome map' derived from HST, we search for mean abundance variations. Based on the NaD line, we find a Na difference of Delta[Na/Fe] = 0.07 +/- 0.01 between the populations. While this difference is smaller than typically found in ancient GCs (which may suggest a correlation with age), this result further confirms that the MP phenomenon is the same, regardless of cluster age and host galaxy. As such, these young clusters offer some of the strictest tests for theories on the origin of MPs.
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