| 1. |
- Alves, Guido, et al.
(författare)
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CSF Aβ42 predicts early-onset dementia in Parkinson disease.
- 2014
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Ingår i: Neurology. - 1526-632X. ; 82:20, s. 1784-90
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Tidskriftsartikel (refereegranskat)abstract
- To test in vivo the proposal from clinicopathologic studies that β-amyloid (Aβ) pathology shortens the time to dementia in Parkinson disease (PD), and to explore the utility of CSF Aβ and related measures as early prognostic biomarkers of dementia in an incident PD cohort.
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| 2. |
- Fitzsimmons, Kathryn E., et al.
(författare)
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Late Quaternary palaeoenvironmental change in the Australian drylands
- 2013
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 74, s. 78-96
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we synthesise existing palaeoenvironmental data from the arid and semi-arid interior of the Australian continent for the period 40-0 ka. Moisture is the predominant variable controlling environmental change in the arid zone. Landscapes in this region respond more noticeably to changes in precipitation than to temperature. Depending on their location, arid zone records broadly respond to tropical monsoon-influenced climate regimes, the temperate latitude westerly systems, or a combination of both. The timing and extent of relatively arid and humid phases vary across the continent, in particular between the westerly wind-controlled temperate latitudes, and the interior and north which are influenced by tropically sourced precipitation. Relatively humid phases in the Murray-Darling Basin on the semi-arid margins, which were characterised by large rivers most likely fed by snow melt, prevailed from 40 ka to the Last Glacial Maximum (LGM), and from the deglacial to the mid Holocene. By contrast, the Lake Eyre basin in central Australia remained relatively dry throughout the last 40 ka, with lake high stands at lake Frome around 35-30 ka, and parts of the deglacial period and the mid-Holocene. The LGM was characterised by widespread relative aridity and colder conditions, as evidenced by extensive desert dune activity and dust transport, lake level fall, and reduced but episodic fluvial activity. The climate of the deglacial period was spatially divergent. The southern part of the continent experienced a brief humid phase around similar to 17-15 ka, followed by increased dune activity around similar to 14-10 ka. This contrasts with the post-LGM persistence of arid conditions in the north, associated with a lapsed monsoon and reflected in lake level lows and reduced fluvial activity, followed by intensification of the monsoon and increasingly effective precipitation from similar to 14 ka. Palaeoenvironmental change during the Holocene was also spatially variable. The early to mid-Holocene was, however, generally characterised by moderately humid conditions, demonstrated by lake level rise, source-bordering dune activity, and speleothem growth, persisting at different times across the continent. Increasingly arid conditions developed into the late Holocene, particularly in the central arid zone.
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| 5. |
- Pihlstrom, L., et al.
(författare)
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Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
- 2013
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 34:6
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Tidskriftsartikel (refereegranskat)abstract
- enome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from 1345 unrelated PD patients and 1225 control subjects collected by collaborating centers in Norway and Sweden. Single-nucleotide polymorphisms representing 18 loci previously reported at genome-wide significance levels were genotyped, as well as 4 near-significant, suggestive, loci. We replicated 11 association signals at p < 0.05 (SNCA, STK39, MAPT, GPNMB, CCDC62/HIP1R, SYT11, GAK, STX1B, MCCC1/LAMP3, ACMSD, and FGF20). The more recently nominated susceptibility loci were well represented among our positive findings, including 3 which have not previously been validated in independent studies. Conversely, some of the more well-established loci failed to replicate. While future meta-analyses should corroborate disease associations further on the level of common markers, efforts to pinpoint functional variants and understand the biological implications of each risk locus in PD are also warranted.
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