| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Fakhri, Yama, et al.
(författare)
-
Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction
- 2018
-
Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736. ; 51:2, s. 195-202
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Terminal "QRS distortion" on the electrocardiogram (ECG) (based on Sclarovsky-Birnbaum's Grades of Ischemia Score) is a sign of severe ischemia, associated with adverse cardiovascular outcome in ST-segment elevation myocardial infarction (STEMI). In addition, ECG indices of the acuteness of ischemia (based on Anderson-Wilkins Acuteness Score) indicate myocardial salvage potential. We assessed whether severe ischemia with or without acute ischemia is predictive of infarct size (IS), myocardial salvage index (MSI) and left ventricular ejection fraction (LVEF) in anterior versus inferior infarct locations. Methods: In STEMI patients, the severity and acuteness scores were obtained from the admission ECG. Based on the ECG patients were assigned with severe or non-severe ischemia and acute or non-acute ischemia. Cardiac magnetic resonance (CMR) was performed 2-6. days after primary percutaneous coronary intervention (pPCI). LVEF was measured by echocardiography 30. days after pPCI. Results: ECG analysis of 85 patients with available CMR resulted in 20 (23%) cases with severe and non-acute ischemia, 43 (51%) with non-severe and non-acute ischemia, 17 (20%) with non-severe and acute ischemia, and 5 (6%) patients with severe and acute ischemia. In patients with anterior STEMI (n = 35), ECG measures of severity and acuteness of ischemia identified significant and stepwise differences in myocardial damage and function. Patients with severe and non-acute ischemia had the largest IS, smallest MSI and lowest LVEF. In contrast, no difference was observed in patients with inferior STEMI (n = 50). Conclusions: The applicability of ECG indices of severity and acuteness of myocardial ischemia to estimate myocardial damage and salvage potential in STEMI patients treated with pPCI, is confined to anterior myocardial infarction.
|
|
| 6. |
- Graae, Anne-Sofie, et al.
(författare)
-
ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations
- 2019
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:3, s. 502-514
-
Tidskriftsartikel (refereegranskat)abstract
- The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and decreased insulin sensitivity and signaling in human skeletal muscle. In line with this, mice lacking Adamts9 selectively in skeletal muscle have improved insulin sensitivity. The molecular link between ADAMTS9 and insulin signaling was characterized further in a model where ADAMTS9 was overexpressed in skeletal muscle. This selective over expression resulted in decreased insulin signaling presumably mediated through alterations of the integrin 131 signaling pathway and disruption of the intracellular cytoskeletal organization. Furthermore, this led to impaired mitochondria! function in mouse muscle-an observation found to be of translational character because humans carrying the ADAMTS9 risk allele have decreased expression of mitochondrial markers. Finally, we found that the link between ADAMTS9 overexpression and impaired insulin signaling could be due to accumulation of harmful lipid intermediates. Our findings contribute to the understanding of the molecular mechanisms underlying insulin resistance and type 2 diabetes and point to inhibition of ADAMTS9 as a potential novel mode of treating insulin resistance.
|
|
| 7. |
- GuðlaugsdÓttir, Hera, et al.
(författare)
-
North Atlantic weather regimes in δ18O of winter precipitation : isotopic fingerprint of the response in the atmospheric circulation after volcanic eruptions
- 2019
-
Ingår i: Tellus. Series B: Chemical and Physical Meteorology. - : Stockholm University Press. - 1600-0889 .- 0280-6509. ; 71:1, s. 1-19
-
Tidskriftsartikel (refereegranskat)abstract
- Equatorial volcanic eruptions are known to impact the atmospheric circulation on seasonal time scales through a strengthening of the stratospheric zonal winds followed by dynamic ocean-atmosphere coupling. This emerges as the positive phase of the North Atlantic Oscillation in the first 5 years after an eruption. In the North Atlantic, other modes of atmospheric circulation contribute to the climate variability but their response to volcanic eruptions has been less studied. We address this by retrieving the stable water isotopic fingerprint of the four major atmospheric circulation modes over the North Atlantic (Atlantic Ridge, Scandinavian Blocking and the negative and positive phases of the North Atlantic Oscillation (NAO − and NAO+)) by using monthly precipitation data from Global Network of Isotopes in Precipitation (GNIP) and 500 mb geo-potential height from the 20th Century Reanalysis. The simulated stable isotopic pattern of each atmospheric circulation mode is further used to assess the retrieved pattern. We test if changes in the atmospheric circulation as well as moisture source conditions as a result of volcanic eruptions can be identified by analyzing the winter climate response after both equatorial and high-latitude North Hemispheric volcanic eruptions in data, reanalysis and simulations. We report of an NAO + mode in the first two years after equatorial eruptions followed by NAO − in year 3 due to a decrease in the meridional temperature gradient as a result of volcanic surface cooling. This emerges in both GNIP data as well as reanalysis. Although the detected response is stronger after equatorial eruptions compared to high latitude eruptions, our results show that the response after high latitude eruptions tend to emerge as NAO − in year 2 followed by NAO + in year 3–4.
|
|
| 8. |
- Guðlaugsdóttir, H., et al.
(författare)
-
The influence of volcanic eruptions on weather regimes over the North Atlantic simulated by ECHAM5/MPI-OM ensemble runs from 800 to 2000 CE
- 2018
-
Ingår i: Atmospheric Research. - : Elsevier BV. - 0169-8095. ; 213, s. 211-223
-
Tidskriftsartikel (refereegranskat)abstract
- The volcanic fingerprint on the winter North Atlantic atmospheric circulation and climate is analyzed in six ensemble runs of ECHAM5/MPI-OM covering 800–2000 CE, both for equatorial and Northern Hemisphere (NH) eruptions. Large volcanic eruptions influence climate on both annual and decadal time scales due to dynamic interactions of different climate components in the Earth's system. It is well known that the North Atlantic Oscillation (NAO) tends to shift towards its positive phase during winter in the first 1–2 years after large tropical volcanic eruptions, causing warming over Europe, but other North Atlantic weather regimes have received less attention. Here we investigate the four dominant weather regimes in the North Atlantic: The negative and positive phase of NAO as well as the Atlantic Ridge, Scandinavian blocking. The volcanic fingerprint is detected as a change in the frequency of occurrence and anomalies in the wind and temperature fields as well as in the sea ice cover. We observe a strong significant increase in the frequency of Atlantic Ridge in the second year after equatorial eruptions that precede the NAO+ detected in year 3–5 as a result of a strong zonal wind anomalies in year 1–2. Evidence for a stronger polar vortex is detected in years 12–14 where NAO+ is detected both as a frequency increase and in the wind and temperature fields. A short-term response is also detected 2–4 years after NH eruptions. The longterm signal after NH eruptions indicate a weak polar vortex around a decade after an eruption. Although the signal after NH eruptions is weaker our results stress the need for further studies. The simulated atmospheric response recorded in ECHAM5 after volcanic eruptions suggest a more dynamic response than previously thought. The methodology used can also be applied to other forcing scenario, for example for future climate projections where the aim is to search for a long-term climate signal.
|
|
| 9. |
- Hjorth Larsen, Ask, et al.
(författare)
-
The atomic simulation environment-a Python library for working with atoms
- 2017
-
Ingår i: Journal of Physics. - : Institute of Physics Publishing (IOPP). - 0953-8984 .- 1361-648X. ; 29:27
-
Forskningsöversikt (refereegranskat)abstract
- The atomic simulation environment (ASE) is a software package written in the Python programming language with the aim of setting up, steering, and analyzing atomistic simulations. In ASE, tasks are fully scripted in Python. The powerful syntax of Python combined with the NumPy array library make it possible to perform very complex simulation tasks. For example, a sequence of calculations may be performed with the use of a simple 'for-loop' construction. Calculations of energy, forces, stresses and other quantities are performed through interfaces to many external electronic structure codes or force fields using a uniform interface. On top of this calculator interface, ASE provides modules for performing many standard simulation tasks such as structure optimization, molecular dynamics, handling of constraints and performing nudged elastic band calculations.
|
|
| 10. |
|
|
