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| 2. |
- Larsson, Jan, et al.
(författare)
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Molecular cloning of the S-adenosylmethionine synthetase gene in Drosophila melanogaster.
- 1994
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Ingår i: FEBS Lett. - 0014-5793. ; 342:3, s. 329-33
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have isolated and sequenced cDNA clones encoding the Drosophila melanogaster S-adenosylmethionine synthetase. The deduced amino acid sequence contains 405 amino acid residues and shows high homology to rat, yeast, Arabidopsis and Escherichia coli counterparts. The gene is transcribed throughout Drosophila development but its main activity is seen in adult males and females. The highest transcription activity is seen in female ovaries. The transcript has an unusually long 5'-untranslated region, which might be of importance for translational regulation
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| 3. |
- Larsson, Åsa, et al.
(författare)
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En observationsstudie av barns gråtbeteende på daghem
- 1994
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Genom deltagande observation insamlades beskrivningar av gråtepisoder (80 episoder) bland 19 stycken 3-6-åringar under tre veckors tid på en daghemsavdelning. De vanligaste orsakerna till att barn började gråta var att de blivit slagna (bitna, rivna, knuffade etc) av något annat barn eller att de inte fått som de velat i någon typ av konfliktsituation.
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| 4. |
- Rasmuson-Lestander, Åsa, et al.
(författare)
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Position-effect variegation and z1 mediated white repression in the In(1)wis system in Drosophila melanogaster.
- 1993
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Ingår i: Hereditas. - 0018-0661. ; 119:3, s. 209-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have characterized a new X-chromosomal inversion in Drosophila melanogaster, extending from just distal of white to just proximal of the bb locus. The inversion places the w-isoxanthopterinless (wis) allele close to heterochromatin and under the influence of position-effect variegation (PEV). The wis gene activity is also regulated by chromosome pairing-dependent z1-mediated repression. By changing the environment, using specific second site modifiers, altering the amount of heterochromatin, and disturbing the chromosome pairing, we have been able to separately affect the two regulatory phenomena and analyse their respective impact on the wis regulation. We provide evidence that under normal conditions PEV and z1 mediated white repression are additive. However, at extreme levels of wis repression by PEV, changes in the z1-mediated interactions are not observable. This indicates that PEV is epistatic to z1-mediated regulation of wis. We also show that deficiencies in the short arm of Y act as suppressors of the z1-mediated white repression. This suppression does not influence PEV and is thus not due to the lower amount of heterochromatin. We propose that nonhomologous chromosome pairing between X and Y is important for the synapsis-dependent z1-mediated repression of white transcription activity in this system
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| 5. |
- Rasmuson, Åsa, et al.
(författare)
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Somatic and germline mutagenesis assayed by the unstable zeste-white test in Drosophila melanogaster.
- 1992
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Ingår i: Mutagenesis. - 0267-8357. ; 7:3, s. 219-23
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This investigation is an attempt to compare mutation rates in germinal and somatic cells by the use of the unstable zeste-white assay in Drosophila melanogaster. In this system it is possible to use the same genetic end point to measure both somatic mutations (aberrantly pigmented spots in the eyes of adult flies) and germinal mutations (males with aberrantly pigmented eyes). We used two mutagens, formaldehyde and methylmethane sulphonate (MMS), to induce mutations and two different routes of mutagen administration, larval feeding and adult feeding, and scored mutations in somatic as well as germinal cells. Both types of tissues were susceptible to MMS mutagenesis, showing elevated frequencies of both germline mutations and eye spots. Formaldehyde, however, gave no increase in the germinal mutation rate but caused somatic mutations. These were found after larval exposure, but also among the offspring of exposed males, as formation of delayed somatic mutations. The results show that somatic cells are much more sensitive in monitoring induced mutations than germinal cells in this system. We also found that spontaneous mutation rate among germinal cells is 200 times higher than that in somatic cells, which presumably is due to the involvement of a mobile element
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| 6. |
- Styrborn, Karin, et al.
(författare)
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Outcomes of geriatric discharge planning. A quality assurance study from a geriatric rehabilitation ward
- 1994
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Ingår i: Scandinavian Journal of Rehabilitation Medicine. - Oslo, Norway : Scandinavian University Press. - 0036-5505 .- 1940-2228. ; 26:3, s. 167-176
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Tidskriftsartikel (refereegranskat)abstract
- The outcome of a discharge planning procedure at a geriatric rehabilitation ward was studied with an interdisciplinary and multidimensional approach, where medical, nursing, functional and psychosocial factors were included. The patient's own expectations and attitude to functional performance and outcome were explored in an interview at the day of discharge and one month later in a follow-up telephone interview. Data were also collected from registers and medical and professional records. All the 36 patients discharged to their own homes, mostly after home assessment, or to old people's homes were followed up. The median rehabilitation stay was 30 days. Their medical status was stable over time and nursing interventions remained frequent. The functional level was unchanged for 18, and further enhanced for 10 patients. Most patients felt secure at home and received the home help they anticipated. Worries were expressed by one-third on realistic grounds, mainly medical or ideas on the accommodation. Some interventions were required and carried out by the team. Home living was as expected or better for two-thirds of the patients. The timing and the patient's situation at discharge seemed to have been well assessed, with an overall positive outcome after a month at home. Further development of practical multidimensional evaluations adapted to elderly patients is necessary in a quality assurance perspective.
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| 7. |
- Wesslén, Bengt, et al.
(författare)
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Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers
- 1994
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Ingår i: Biomaterials. - : Elsevier BV. - 1878-5905 .- 0142-9612. ; 15:4, s. 278-284
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Tidskriftsartikel (refereegranskat)abstract
- A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones.
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