| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Larsson, Jan, et al.
(författare)
-
Cloning, mapping and mutational analysis of the S-adenosylmethionine decarboxylase gene in Drosophila melanogaster.
- 1997
-
Ingår i: Mol Gen Genet. - 0026-8925. ; 256:6, s. 652-60
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- S-adenosylmethionine decarboxylase is a key enzyme in the synthesis of polyamines. These small cationic molecules are required for growth and development in all organisms. A wealth of biological processes, including synthesis of DNA and protein and condensation of chromatin, involve polyamines. Inhibition of polyamine synthesis has been proposed for treatment of cancer but this requires more knowledge about the in vivo function of polyamines. We report here the cloning of the S-adenosylmethionine decarboxylase gene from Drosophila melanogaster and the analysis of corresponding mutants. The mutant phenotypes are similar to those previously described for ribosomal protein genes (Minutes) and rRNA genes (bobbed). This work elucidates the in vivo consequences of impaired polyamine synthesis with respect to the development of a whole animal.
|
|
| 5. |
- Larsson, Jan, et al.
(författare)
-
Mutations in the Drosophila melanogaster gene encoding S-adenosylmethionine synthetase [corrected] suppress position-effect variegation.
- 1996
-
Ingår i: Genetics. - 0016-6731. ; 143:2, s. 887-96
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In Drosophila melanogaster, the study of trans-acting modifier mutations of position-effect variegation and Polycomb group (Pc-G) genes have been useful tools to investigate genes involved in chromatin structure. We have cloned a modifier gene, Suppressor of zeste 5 (Su(z)5), which encodes S-adenosylmethionine synthetase, and we present here molecular results and data concerning its expression in mutants and genetic interactions. The mutant alleles Su(z)5, l(2)R23 and l(2)M6 show suppression of wm4 and also of two white mutants induced by roo element insertions in the regulatory region i.e., wis (in combination with z1) and wsp1. Two of the Su(z)5 alleles, as well as a deletion of the gene, also act as enhancers of Polycomb by increasing the size of sex combs on midleg. The results suggest that Su(z)5 is connected with regulation of chromatin structure. The enzyme S-adenosylmethionine synthetase is involved in the synthesis of S-adenosylmethionine, a methyl group donor and also, after decarboxylation, a propylamino group donor in the bio-synthesis of polyamines. Our results from HPLC analysis show that in ovaries from heterozygous Su(z)5 mutants the content of spermine is significantly reduced. Results presented here suggest that polyamines are an important molecule class in the regulation of chromatin structure.
|
|
| 6. |
- Larsson, Jan, et al.
(författare)
-
Somatic and germline clone analysis in mutants of the S-adenosylmethionine synthetase encoding gene in Drosophila melanogaster.
- 1998
-
Ingår i: FEBS Lett. - 0014-5793. ; 427:1, s. 119-23
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have analysed the phenotypic consequences of homozygous mutant clones in the S-adenosylmethionine synthetase encoding gene in Drosophila melanogaster. The results suggest that SamS function is required for cell proliferation/growth in embryonic/early larval cells and during development of imaginal disc cells. Homozygous SamS germline clones can, however, develop and give rise to viable heterozygous offspring. This offspring expresses a Minute-like phenotype. We suggest that this phenotype is caused by an obstruction of the polyamine biosynthesis
|
|
| 7. |
- Larsson, Åsa, 1965-, et al.
(författare)
-
Computer-assisted cognitive rehabilitation for adults with traumatic brain damage : Four case studies
- 1995
-
Ingår i: Occupational Therapy International. - : John Wiley & Sons. - 0966-7903 .- 1557-0703. ; 2:3, s. 166-189
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of the study was to investigate the value of computer-assisted activities for four individuals with brain damage. Individuals were trained in cognitive functions in their homes to compensate for cognitive impairment, assisted in work activities and helped in leisure time occupations. The four people received individually adapted computers and peripheral equipment, and the environment was changed to accommodate their needs. Each person received guidance and instruction from an occupational therapist once or twice a week for 12–18 weeks. The goals for each person were achieved according to evaluation with Goal Attainment Scaling.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
