| 1. |
- Lindehammer, Sabina, et al.
(författare)
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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
- 2008
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Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
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| 2. |
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| 3. |
- Brodin, Lars-Åke, et al.
(författare)
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Global and local detection of blood vessel elasticity
- 2006
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Patent (populärvet., debatt m.m.)abstract
- The present invention is a non-invasive analysis system for detection of global and local blood vessel elasticity. The analysis system comprises two subsystems where subsystem 1 is data collecting unit and subsystem 2 is an analysis unit. The data collecting unit comprises one or many non-invasive image generating systems, or the data collecting system makes the registration possible of movement parameters that quantifies the dynamics of the blood vessel wall in longitudinal and radial directions. Subsystem 2 performs Wave Intensity Analysis which is an analysis method using co-related parts of the circulation system by measuring the intensity change (dl) of the blood vessel during a heart cycle. The intensity change is calculated as the product of the pressure derivate and the flow velocity derivate. In subsystem 2 the changes of pressure and flow are approximated by the deformation velocity or velocity of the radial and longitudinal direction, respectively. By calculating time constants and amplitudes of the intensity change graph a measure is obtained of the local and global elasticity of the blood vessel and atherosclerotic constrictions of arterial vessels may then be identified at an early stage.
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| 4. |
- Flordal Thelander, Emma, et al.
(författare)
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Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma
- 2007
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Ingår i: Leukemia research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 31:9, s. 1219-1230
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Tidskriftsartikel (refereegranskat)abstract
- Mantle cell lymphoma (MCL) is characterized by over-expression of cyclin Dl as a result of the characteristic t(11;14)(q13;q32). However, this translocation alone has proven not to be sufficient for lymphomagenesis, suggesting the involvement of additional alterations. We have characterized 35 cases of MCL by array comparative genomic hybridization with an average resolution of 0.97Mb distributed over the complete human genome. The most common alterations were losses in 1p13.2–p31.1, 6q16.2–q27, 8p21.3, 9p13.2–p24.3, 9q13–q31.3, 11q14.3–q23.3, 13q14.13–q21.31, 13q33.1–q34, and 22q11.23–q13.33 and gains involving 3q21.2–q29, 7p12.1–p22.3, 8q24.13–q24.23, and 18q21.33–q22.3. Four homozygous deletions were identified in totally three patients; two overlapping at 1p32.3, and two adjacent at 13q32.3. The homozygous deletions at 1p32.3 cover the CDKN2C locus (coding for p18), while the region at 13q32.3 does not encompass any known tumor suppressor genes. A gain in 3q was significantly associated with shorter survival (P=0.047).
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| 5. |
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| 6. |
- Muthukumar, Kaliappan, et al.
(författare)
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Cerium Endohedral fullerenes (Ce@C82 and Ce2@C80) Theoretical Interpretations for Experimental observation
- 2008
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Konferensbidrag (refereegranskat)abstract
- Many questions remain unanswered for the endohedral fullerenes. Owing to the improvement in separation of isomers and in theoretical studies (DFT and ab-initio) evolving as imperative tool for characterization; these can be addressed.1;2 Understanding of the position and binding configuration of the metal atom inside the cage is crucial as it controls the structural and electronic properties of the molecule.3 Theoretical calculations proved to be efficient in explaining many controversies in the field of lanthanoid endohedral fullerenes.2-5 Fig; Ce2@C80; Ce2@C78) DFT optimized structures of Ce2@C80 D3d and Ce2@C78 D3h Here in this study we use DFT to characterize Ce doped metallofullerenes and report some surprising theoretical findings on the binding of cerium inside various carbon cages; (C60; C78; C80; C82). We observe that the presence of an additional Ce atom puts restrictions on the binding in the C80 cage6; but this does not happen in the C78 cage. We explain the reason behind this by analyzing the electronic structure. Further various spectra (RESPES; IETS; STM/STS) have been simulated for Ce@C82 and Ce2@C80 which we compare and discuss with experiments
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| 7. |
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| 8. |
- Muthukumar, Kaliappan, et al.
(författare)
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Surprising Findings for Ce Doped Fullerenes and Understanding of Experiments through Theoretical Modelling A DFT Approach
- 2008
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Endohedral fullerenes; which have one metal atom encapsulated; are relatively well studied compared to species that have two elements inside the cage.1-5 Cerium; the most reactive elements of the rare earth group can be encapsulated into fullerene (C78; C80; C82) cages;1 which works as a n-dopant and in the incarcerated form it can be used as quantum bits in quantum computing2. Understanding of the position and binding pattern of the metal atom inside the cage is important as it controls the structural and electronic properties of the molecule. We found that Ce in Ce@C82 has a specific and unique binding site in C82-C2v and has a C2v symmetric structure; which is explained by the specific charge pattern of this binding site and the symmetry of the MO s that comply well with the Ce d orbital bonding.6 This six-membered ring binding site is also favored by La in La@C82. Each of the six-membered rings of C80-Ih fulfills this symmetry criterion and therefore a similar kind of binding site is expected for Ce in Ce2@C80. But; we observe a novel binding site for Ce in presence of an additional cerium atom; while La preserve its usual binding pattern in La2@C80 as in La@C82.7 We here discuss and analyze the reason for the preference of novel binding site of Ce atoms in C80-Ih by explaining the competitive binding nature of Ce-Ce and Ce-C. Surprisingly; Ce in Ce2@C78 unlike Ce2@C80 has its binding pattern as in Ce@C60 and in Ce@C82 (binding to a six-membered ring). We explain this variation in binding together with the nature of the charge transfer between the Ce atoms and the cage (C82 and C80). In addition; we explain experimental observations for Ce@C82 and Ce2@C80 from RESPES; IETS; STM/STS spectra by comparison with simulated properties
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| 9. |
- Muthukumar, Kaliappan, et al.
(författare)
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Theoretical Predictions and Explanation of Experimental Observations for Ce Doped Fullerenes
- 2008
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Konferensbidrag (refereegranskat)abstract
- Fullerenes that have one metal atom encapsulated; for example M@C60; M@C70; M@C82; (M= Sc; Y; La; Ce; etc.) are relatively well studied compared to species that have two elements inside the cage.1-4 We recently reported the structure of Ce@C82 and explained the preferential binding site of Ce to only one of the thirty-one 6-membered rings of C82-C2v cage by identifying its specific charge pattern and the symmetry of the MO s that comply well with the Ce d orbital bonding.5 Since; each of the six-membered rings of C80-Ih fulfill the proposed criteria; similar kind of binding site is expected for Ce in Ce2@C80. But; we observe a novel binding site for Ce in presence of an additional cerium atom; while La in La2@C80 does bond with six-membered rings.6 In this study; we discuss and analyze the reason for the preference for a novel binding site by Ce atoms in C80-Ih through density functional calculations. Further; we explain the nature of the charge transfer between the Ce atoms and the cage (C82 and C80) and elucidate the oxidation state of Ce in these metallofullerenes by comparing the charge transfer in the conventional Ce tri halides (CeF3; CeBr3). In addition; we explain experimental observations for Ce@C82 and Ce2@C80 from RESPES; IETS; STM/STS spectra by comparison with simulated properties
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| 10. |
- Persdotter, Sofia, et al.
(författare)
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Cooperative inhibitory effects of budesonide and formoterol on eosinophil superoxide production stimulated by bronchial epithelial cell conditioned medium
- 2007
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Ingår i: International Archives of Allergy and Immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 143:3, s. 201-210
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Tidskriftsartikel (refereegranskat)abstract
- Background: Improved asthma control by combinations of inhaled glucocorticosteroids (GCs) and long-acting beta(2)-agonists (LABAs) includes a reduced frequency and severity of exacerbations. In view of the association of exacerbations with increased airway inflammation, the question has arisen as to whether LABAs are able to complement the known anti- inflammatory activity of GCs. To address this, we studied the effects of a LABA, formoterol (FORM), and a GC, budesonide (BUD), alone and in combination, on bronchial epithelial cell-mediated eosinophil superoxide production in vitro. Methods: We employed 2 experimental approaches. First, superoxide production by human eosinophils incubated with conditioned medium (CM) from human bronchial epithelial cells cultured for 24 h with vehicle, BUD, FORM or BUD + FORM was measured (Epi/Eos assay). Second, eosinophils were stimulated with vehicle-CM to which the drugs were added (Eos assay). Superoxide production was determined as the superoxide dismutase-inhibitable reduction of ferricytochrome C. Results: CM increased eosinophil superoxide generation (p < 0.01) and epithelial-derived granulocyte macrophage colony-stimulating factor was the mediator responsible. In both assays, FORM dose-dependently inhibited eosinophil superoxide similarly and in the same concentration range as BUD. The BUD + FORM combination was more effective than BUD alone, and it completely inhibited CM-induced superoxide production in the Epi/Eos assay, suggesting complementary effects of both drugs on bronchial epithelial cells and eosinophils. Conclusions: The cooperative, inhibitory effects of BUD and FORM on eosinophils and bronchial epithelial cells, in terms of their effects on eosinophil superoxide production, may represent a possible mechanism for the enhanced anti-inflammatory efficacy of BUD and FORM combination therapy of asthma. Copyright (c) 2007 S. Karger AG, Basel
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