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- Agrell, Christina, et al.
(författare)
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Beskrivningar av pojkar och flickor i sociala utredningar i LVU-ärenden
- 1997
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet är att undersöka om det finns skillnader i hur pojkar och flickor beskrivs i barnavårdsutredningar. De senaste 26 LVU-fallen från två kammarrätter och sju länsrätter, räknat från den 1 oktober 1997 och bakåt granskades, 13 ärenden med pojkar och 13 med flickor. Uppdelning skedde i miljöfall och beteendefall. Ett flertal skillnader mellan könen kan konstateras. Exempelvis beskrivs pojkar som aggressiva och hotfulla och som en fara för andra. Flickor beskrivs som farliga för sig själva. I miljöfallen beskrivs flickorna som rädda, ledsna och oroliga. I samtliga utredningar förekommer inga eller ytterst få situationsbeskrivningar kopplade till de personbeskrivande orden.
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- Carlsson, C., et al.
(författare)
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Experimental and simulated fluorescence depolarization due to energy transfer as tools to study DNA-dye interactions
- 1997
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Ingår i: Biopolymers. - 0006-3525 .- 1097-0282. ; 41:5, s. 481-494
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Tidskriftsartikel (refereegranskat)abstract
- A method to study DNA-dye complexes by the combination of steady state fluorescence anisotropy measurements and computer simulations of the fluorescence depolarization due to resonance energy transfer is presented. The simulations are based on a Markov chain analysis, assuming random distribution of the dyes along the DNA chain and energy transfer that obeys Forster kinetics. Since the investigated intercalators (ethidium bromide, YO, PO) and groove binders [4'6-diamidino-2-phenylindole (DAPI)] were found to show different depolarization dependence on binding density, the method can be used to quite sensitively characterize the binding mode. Excellent agreement between the measured and simulated anisotropy is found for all investigated intercalators. The proposed method gives an estimation of the unwinding angle for intercalators and provides information about the binding site size, and the presence or absence of sequence specificity. For the groove binder DAPI interacting with mixed sequenced DNA, the measured and computed depolarization do not agree, and this can be rationalized in terms of the high sequence specificity of this dye. However, for DAPI bound to [poly(dA-dT)](2) the measured data agree well with computed data for a groove binder that is displaced a distance 7 Angstrom from the helix axis and has a binding site size of three bases. (C) 1997 John Wiley & Sons, Inc.
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- Edgren, M, et al.
(författare)
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Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomas.
- 1999
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 19:1B, s. 869-73
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Tidskriftsartikel (refereegranskat)abstract
- Sixty nine patients with urogenital cancers (renal, bladder and prostate cancer) were studied to determine whether the serum concentrations of Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (b-FGF) reflected the status of the patients and/or the prognosis of the disease. Of the patients included in this study, renal cell carcinoma patients expressed the highest levels of VEGF indicating that these tumours are more VEGF dependent. The values of b-FGF could be considered normal in all three malignancies. No correlation was observed between the expression of VEGF and b-FGF, nor between VEGF and b-FGF and patients survival.
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- Hjälm, Göran, et al.
(författare)
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Cloning and sequencing of human gp330, a Ca2+ -binding receptor with potential intracellular signaling properties
- 1996
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Ingår i: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 239:1, s. 132-137
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Tidskriftsartikel (refereegranskat)abstract
- We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats. The deduced 4655 amino acid residues give a calculated molecular mass of 519636 Da for the mature protein and consists of a probable 25-amino-acid N-terminal signal peptide sequence, an extracellular region of 4398 amino acids, a single transmembrane-spanning domain of 23 amino acids, and an intracellular C-terminal region of 209 amino acid residues. Three types of cysteine-rich repeats characteristic of the low density lipoprotein receptor (LDLR) superfamily are present in human gp330. In the extracellular region, there are a total of 36 LDLR ligand-binding repeats, comprising four distinct domains, 16 growth factor repeats separated by eight YWTD spacer regions, and one epidermal growth factor-like repeat. No consensus cleavage sequence for the processing endoprotease furin is detected in human gp330. The intracellular tail contains not only two copies of the F(X)NPXY coated-pit mediated internalization signal characteristic of LDLR superfamily members, but also intriguing and potentially functional motifs including several Src-homology 3 recognition motifs, one Src-homology 2 recognition motif for the p85 regulatory subunit of phosphatidylinositol 3-kinase, and additional sites for protein kinase C, casein kinase II and cAMP-/cGMP-dependent protein kinase. There is approximately 77% amino acid identity between human and rat gp330 with minor differences between the extracellular and intracellular regions. Recently gp330 has been implicated in Ca2+ regulation in the parathyroid, the placenta, and the renal tubule, but its overall physiological and pathological role still remains uncertain.
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