| 1. |
- Bardizbanyan, Alen, 1986, et al.
(författare)
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Improving data access efficiency by using context-aware loads and stores
- 2015
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Ingår i: Proc. 16th ACM SIGPLAN/SIGBED Conference on Languages, Compilers, and Tools for Embedded Systems. - New York : ACM Press. - 0730-8566. - 9781450332576 ; , s. 27-36
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Konferensbidrag (refereegranskat)abstract
- Memory operations have a significant impact on both performance and energy usage even when an access hits in the level-one data cache (L1 DC). Load instructions in particular affect performance as they frequently result in stalls since the register to be loaded is often referenced before the data is available in the pipeline. L1 DC accesses also impact energy usage as they typically require significantly more energy than a register file access. Despite their impact on performance and energy usage, L1 DC accesses on most processors are performed in a general fashion without regard to the context in which the load or store operation is performed. We describe a set of techniques where the compiler enhances load and store instructions so that they can be executed with fewer stalls and/or enable the L1 DC to be accessed in a more energy-efficient manner. We show that using these techniques can simultaneously achieve a 6% gain in performance and a 43% reduction in L1 DC energy usage.
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| 2. |
- Da Silva Faria Oliveira, Fábio Luis, 1985, et al.
(författare)
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Genomic and transcriptomic analysis of Candida intermedia reveals important genes for xylose utilization
- 2018
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The urgency to reduce carbon emissions and to lower our dependence on oil makes it necessary to strive towards a more sustainable bio-based economy, where energy, chemicals, materials and food are produced from renewable resources. Lignocellulosic biomass constitutes a great source of raw material for such a future bio-based economy since it is widely available, relatively inexpensive and do not compete with food and feed production. The pentose D-xylose, the second most prevalent sugar in lignocellulose after glucose, is an underutilized resource, in large due to the inefficient fermentation of this sugar by the most industrially relevant microorganisms (e.g. Saccharomyces cerevisiae). Thus, development of microorganisms that can ferment all lignocellulosic sugars is of foremost importance for economically viable production processes. Native xylose-utilizing yeasts represent a major source of knowledge and genes for xylose uptake and assimilation that can be transferred to S. cerevisiae. The yeast Candida intermedia is an interesting candidate to characterize further, as it displays a high xylose transport capacity and multiple xylose reductases, of which one appears to prefer NADH over NAPDH. Furthermore, the C. intermedia strain CBS 141442, isolated in the liquid fraction of wheat straw hydrolysate in our laboratory as a contaminant of a xylose fermenting population of S. cerevisiae, is capable of glucose and xylose co-fermentation under certain conditions. The aim of this study was to elucidate the genetic features that are the basis of the xylose utilization capacity of C. intermedia CBS141442. PacBio sequencing and de novo assembly of the genome revealed a haploid yeast with a genome size of 13.2 Mb and a total of 5936 protein-coding genes spread over seven chromosomes. In order to gain insight on the genes involved in the utilization of xylose, we analysed the changes in the transcriptome of C. intermedia CBS141442 during growth in xylose and glucose (as reference condition). Cells were collected in mid-exponential phase at the maximum growth rate when no metabolites were accumulating. The total RNA was extracted and cDNA libraries were prepared after polyA selection. Each sample was sequenced in an Illumina HiSeq2500 system with an average cover of 5-20 million reads. The analysis of the differential expression data lead to the identification of two new genes potentially encoding xylose transporters and no less than three xylose reductases genes with different expression patterns. The xylose reductase genes were heterologously expressed in S. cerevisiae to determine their co-factor preferences and substrate specificities. Whereas two of them are strictly NADPH-dependent, the third can use both co-factors and shows preference for NADH. The heterologous expression of this gene can improve the capacity of S. cerevisiae to ferment xylose, and thus contribute to a more efficient use of lignocellulosic biomass.
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| 3. |
- Larsson, David, 1986, et al.
(författare)
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Retention rate of first antiepileptic drug in poststroke epilepsy: A nationwide study
- 2019
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Ingår i: Seizure. - : Elsevier BV. - 1059-1311 .- 1532-2688. ; 64, s. 29-33
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To describe the retention rates of first antiepileptic drugs (AEDs) in patients with poststroke epilepsy on a nationwide scale. Methods: The Swedish Stroke Register, which has 94% coverage and high-resolution data on stroke, comorbidities, and disability, was cross-referenced to the National Patient Register, Drug Register, and Cause-of-Death Register. Patients with onset of AED-treated epilepsy after stroke in 2005–2010 were included. An algorithm based on prescription renewal intervals was used to analyze treatment data until the end of 2014. Results: A total of 4991 patients were included. First AEDs analyzed were carbamazepine (n = 2373), valproic acid (n = 943), levetiracetam (n = 555), lamotrigine (n = 519), phenytoin (n = 176), and oxcarbazepine (n = 89). The five-year retention rate was highest for lamotrigine (75%, 95%CI:70.4–79.4), followed by levetiracetam (69%, 95%CI:62.9–74.3), oxcarbazepine (68%, 95%CI:55.2–79.8), valproic acid (62%, 95%CI:57.8–66.4), carbamazepine (60%, 95%CI:57.6–62.4), and phenytoin (55%, 95%CI:45.2–64.0). There were minor differences in baseline characteristics with low levels of disability being slightly more common in patients treated with lamotrigine and levetiracetam. Atrial fibrillation and hypertension were more common in patients treated with levetiracetam, and atrial fibrillation was less common in patients treated with carbamazepine. In a Cox model adjusted for baseline characteristics, the risk of discontinuation was lower for lamotrigine (HR 0.53, 95%CI:0.43-0.67) and levetiracetam (HR 0.75, 95%CI:0.60-0.94) when compared to carbamazepine. Conclusions: Lamotrigine and levetiracetam have higher retention rates than carbamazepine in poststroke epilepsy. This is in agreement with existing small RCTs in this patient group. © 2018 British Epilepsy Association
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| 4. |
- Lindskog, Cecilia, et al.
(författare)
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The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
- 2015
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- Background: To understand cardiac and skeletal muscle function, it is important to define and explore their molecular constituents and also to identify similarities and differences in the gene expression in these two different striated muscle tissues. Here, we have investigated the genes and proteins with elevated expression in cardiac and skeletal muscle in relation to all other major human tissues and organs using a global transcriptomics analysis complemented with antibody-based profiling to localize the corresponding proteins on a single cell level. Results: Our study identified a comprehensive list of genes expressed in cardiac and skeletal muscle. The genes with elevated expression were further stratified according to their global expression pattern across the human body as well as their precise localization in the muscle tissues. The functions of the proteins encoded by the elevated genes are well in line with the physiological functions of cardiac and skeletal muscle, such as contraction, ion transport, regulation of membrane potential and actomyosin structure organization. A large fraction of the transcripts in both cardiac and skeletal muscle correspond to mitochondrial proteins involved in energy metabolism, which demonstrates the extreme specialization of these muscle tissues to provide energy for contraction. Conclusions: Our results provide a comprehensive list of genes and proteins elevated in striated muscles. A number of proteins not previously characterized in cardiac and skeletal muscle were identified and localized to specific cellular subcompartments. These proteins represent an interesting starting point for further functional analysis of their role in muscle biology and disease.
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| 5. |
- Moreau, Daniel, 1990, et al.
(författare)
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Practical Way Halting by Speculatively Accessing Halt Tags
- 2016
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Ingår i: 19th Design, Automation and Test in Europe Conference and Exhibition, DATE 2016, Dresden, Germany, 14-18 March 2016. - Singapore : Research Publishing Services. - 1530-1591. - 9783981537062 ; , s. 1375-1380
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Konferensbidrag (refereegranskat)abstract
- Conventional set-associative data cache accesses waste energy since tag and data arrays of several ways are simultaneously accessed to sustain pipeline speed. Different access techniques to avoid activating all cache ways have been previously proposed in an effort to reduce energy usage. However, a problem that many of these access techniques have in common is that they need to access different cache memory portions in a sequential manner, which is difficult to support with standard synchronous SRAM memory. We propose the speculative halt-tag access (SHA) approach, which accesses low-order tag bits, i.e., the halt tag, in the address generation stage instead of the SRAM access stage to eliminate accesses to cache ways that cannot possibly contain the data. The key feature of our SHA approach is that it determines which tag and data arrays need to be accessed early enough for conventional SRAMs to be used. We evaluate the SHA approach using a 65-nm processor implementation running MiBench benchmarks and find that it on average reduces data access energy by 25.6%.
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| 6. |
- von Fieandt, Linus, et al.
(författare)
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Corrosion properties of CVD grown Ti(C,N) coatings in 3.5 wt-% NaCl environment
- 2018
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Ingår i: Corrosion Engineering, Science and Technology. - 1478-422X .- 1743-2782. ; 53:4, s. 316-320
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Tidskriftsartikel (refereegranskat)abstract
- The corrosion behaviour of Titanium carbonitride (Ti(C,N)) films grown by chemical vapour deposition was analysed in artificial sea water environment. From potentiodynamic polarisation curves, two passivation zones were detected, which originated from an initial oxidation of TiC and TiN to TiO2 followed by growth of the TiO2 layer upon increased polarisation. X-ray photoelectron spectroscopy analyses verified the mechanism by detecting a gradual decrease in Ti(C,N) peaks accompanied by a gradual increase of oxidised Ti (e.g. TiO2). It was likewise found that carbon in TiC mainly decomposes into carbonate species while the nitrogen in TiN remains elemental and likely escapes as nitrogen gas. Accordingly, Ti(C,N) behaves like a superposition of TiC and TiN with their individual oxidation behaviour, resulting in a highly corrosion resistant material.
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| 7. |
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| 9. |
- Xiros, Charilaos, 1973, et al.
(författare)
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Toward a sustainable biorefinery using high-gravity technology
- 2017
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Ingår i: Biofuels, Bioproducts and Biorefining. - : Wiley. - 1932-1031 .- 1932-104X. ; 11:1, s. 15-27
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Tidskriftsartikel (refereegranskat)abstract
- The realization of process solutions for a sustainable bioeconomy depends on the efficient processing of biomass. High-gravity technology is one important alternative to realizing such solutions. The aims of this work were to expand the knowledge-base on lignocellulosic bioconversion processes at high solids content, to advance the current technologies for production of second-generation liquid biofuels, to evaluate the environmental impact of the proposed process by using life cycle assessment (LCA), and to develop and present a technically, economically, and environmentally sound process at high gravity, i.e., a process operating at the highest possible concentrations of raw material. The results and opinions presented here are the result of a Nordic collaborative study within the framework of the HG Biofuels project. Processes with bioethanol or biobutanol as target products were studied using wheat straw and spruce as interesting Nordic raw materials. During the project, the main scientific, economic, and technical challenges of such a process were identified. Integrated solutions to these challenges were proposed and tested experimentally, using wheat straw and spruce wood at a dry matter content of 30% (w/w) as model substrates. The LCA performed revealed the environmental impact of each of the process steps, highlighting the importance of the enzyme dose used for the hydrolysis of the plant biomass, as well as the importance of the fermentation yield.
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| 10. |
- Zelano, Johan, 1981, et al.
(författare)
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Pre-stroke seizures: A nationwide register-based investigation
- 2017
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Ingår i: Seizure-European Journal of Epilepsy. - : Elsevier BV. - 1059-1311 .- 1532-2688. ; 49, s. 25-29
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The relationship between cerebroyascular disease and seizures is clearly illustrated by poststroke epilepsy. Seizures can also be the first manifestation of cerebrovascular disease and case control studies have demonstrated that seizures carry an increased risk of subsequent stroke. Thus, seizures could serve as a marker for vascular risk that merits intervention, but more data is needed before proper trials can be conducted. The occurrence of pre-stroke seizures has not been assessed on a national scale. We asked what proportion of strokes in middle-aged and elderly patients was preceded by seizures. Methods: All patients over 60 years of age with first-ever stroke in 2005-2010 (n = 92,596) were identified in the Swedish stroke register (Riksstroke) and cross-sectional data on a history of a first seizure or epilepsy diagnosis in the ten years preceding stroke were collected from national patient registers with mandatory reporting. Results: 1372 patients (1.48%) had a first seizure or epilepsy diagnosis registered less than ten years prior to the index stroke. The mean latency between seizure and stroke was 1474 days (SD 1029 days). Conclusions: Seizures or epilepsy preceded 1.48% of strokes in patients > 60 years of age. Based on recent national incidence figures, 5-20% of incident cases of seizures or epilepsy after 60 years of age could herald stroke, depending on age group. These proportions are of a magnitude that merit further study on how to reduce the risk of stroke in patients with late-onset seizures or epilepsy. (C) 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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