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- Larsson, Håkan, 1949-, et al.
(författare)
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Organisationens mänskliga insida : om det sociala arbetets utvecklingsmöjligheter
- 1988
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study is to develop such theoretical perspectives as will increase our understanding of social work organizations, and help us improve them. Consequently, the research approach is longterm and primarily theoretical in character: What demand must be made of an organization where people deal with people?One important assumption is that the relationships between the actors in an enterprise constitute the organization. These relations are maintained i.a. by speech-acts, and language therefore becomes one of the forms in which the organization manifests itself; the organization is to be found within the language and reveals important aspects of its own nature via the language it employs. - What, then, does the specific language of the organization reveal?In the empirical parts of the study communication between social workers and their supervisors in a welfare agency is closely examined. This flow of communication, we assume, contains important aspects of the possibilities for the enterprise to carry out its tasks in a succesful way. A question of particular interest is that of "hierarchization principles" - concerning, for instance the conditions and principles that regulate the position of the individual in the social system, how experience and knowledge are accumulated, disseminated and legitimized within the organization, how the system of responsibility is construed.According to the results, the organization studied did not manage to sufficiently transfer knowledge, experience and competence within the system. Furthermore, a set of norms established by the actors and maintained by them created a barrier between the organization and its users/clients. This set of norms, however, was invisible to the actors themselves.The final chapter of the study discusses the possibility of regarding the organization as a symbol space - as an arena for legitimized acting. In such a perspective, the organization would appear as a linguistic system; an approach which could reveal hidden aspects and introduce new and different possibilities for interpretation.
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- Larsson, Håkan, 1952-
(författare)
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Profilactin and the regulation of actin assembly and disassembly
- 1985
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Actin filament assembly and disassembly are believed to be fundamental steps in the mechanism of cell motility in non-muscle cells. Profilactin is a complex between monomeric actin and a small protein, profilin, which inhibits the polymerization of the actin. It is assumed that profilactin is an unpolymerized storage form of actin in the cell and that profilin is of central importance to the regulation of actin physiology. Previously, biochemical characterization of calf spleen profilactin has been difficult because of a disturbing variability in the stability between different preparations of the complex.This thesis demonstrates that the major reason for the variation in the stability of profilactin was the presence of minute amounts of contaminating protein factors that affect actin polymerization, presumably by binding specifically to one of the ends of the actin polymer. Conditions for the removal of these contaminating factors have been worked out and for the isolation of intact homogeneous profilin and actin. It is shown that the properties of the reconstituted complex are essentially the same as those of the isolated 'native' complex. The effects of profilin on spleen actin assembly and disassembly have been studied and apparent dissociation constants have been determined for the spleen complex as well as for the heterologous complex formed between spleen profilin and actin isolated from rabbit skeletal muscle. Finally, it has been shown that the spleen proteins, both separately and as a complex, specifically interact with detergents and the hydrophobic probe DPH.
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- Larsson, Hans, et al.
(författare)
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Studies on blood viscosity during the menstrual cycle and in the postmenopausal period in healthy women
- 1989
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - 0001-6349 .- 1600-0412. ; 68, s. 483-486
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Blood viscosity was measured in 14 healthy, menstruating women, aged 17-51 years and in 10 healthy, postmenopausal women, aged 55-64 years. The fertile women were studied once a week during a normal menstrual cycle and the postmenopausal women twice with an interval of 2 weeks. Blood viscosity was measured at natural hematocrit as well as at hematocrit 45%. In the postmenopausal women no changes in blood viscosity were found. In the fertile women, blood viscosity at hematocrit 45% was lowest at the start of the menstrual bleeding and increased to a peak at day 7 (p < 0.01), with a similar pattern when measured at natural hematocrit. Plasma viscosity also had its lowest value at the onset of menstrual bleeding, increasing to a maximum at day 21. Changes in plasma triglycerides, but not in fibrinogen or cholesterol, seemed to contribute to this increase. Plasma factors only partly explained the variations in blood viscosity, and changes in red cell properties were also found to be of importance. The clinical significance of these rheological changes remains to be established, but at least theoretically there may be an increased risk for thromboembolism, e.g. at surgery, during days 5-15 of the cycle. In studies on blood flow and rheological conditions in fertile women, it seems advisable to standardize for time in the menstrual cycle.
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