| 1. |
- Nilsson, Anna-Lena, et al.
(författare)
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Relationship between Ljungan virus antibodies, HLA-DQ8, and insulin autoantibodies in newly diagnosed type 1 diabetes children
- 2013
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Ingår i: Viral immunology. - : Mary Ann Liebert, Inc.. - 0882-8245 .- 1557-8976. ; 26:3, s. 207-215
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Tidskriftsartikel (refereegranskat)abstract
- Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL and 4th quartile LVAb were found in 25% (170/676) of which 64% were < 10 (n = 108, p < 0.0001), and 27% were < 5 (n = 45; p < 0.0001) years old. The 4th quartile LVAb in children < 10 years of age correlated to HLA DQ2/8, 8/8, and 8/X (p < 0.0001). Furthermore, in the group with 4th quartile LVAb, 55% were IAA positive (p = 0.01) and correlation was found between 4th quartile LVAb and IAA in children < 10 years of age (p = 0.035). It is concluded that 1) LVAb were common among the young T1D patients and LVAb levels were higher in the younger age groups; 2) 4th quartile LVAb correlated with IAA; and 3) there was a correlation between 4th quartile LVAb and HLA-DQ8, particularly in the young patients. The presence of LVAb supports the notion that prior exposure to LV may be associated with T1D.
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| 2. |
- Andersson, Cecilia K, et al.
(författare)
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Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
- 2013
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 14:5, s. 341-349
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS: In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT. RESULTS: All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03). CONCLUSION: Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.
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| 3. |
- Axell, Erik
(författare)
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Spectrum Sensing Algorithms Based on Second-Order Statistics
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cognitive radio is a new concept of reusing spectrum in an opportunistic manner. Cognitive radio is motivated by recent measurements of spectrum utilization, showing unused resources in frequency, time and space. Introducing cognitive radios in a primary network inevitably creates increased interference to the primary users. Secondary users must sense the spectrum and detect primary users' signals at very low SNR, to avoid causing too much interference.This dissertation studies this detection problem, known as spectrum sensing.The fundamental problem of spectrum sensing is to discriminate an observation that contains only noise from an observation that contains a very weak signal embedded in noise. In this work, detectors are derived that exploit known properties of the second-order moments of the signal. In particular, known structures of the signal covariance are exploited to circumvent the problem of unknown parameters, such as noise and signal powers or channel coefficients.The dissertation is comprised of six papers, all in different ways related to spectrum sensing based on second-order statistics. In the first paper, we considerspectrum sensing of orthogonal frequency-division multiplexed (OFDM) signals in an additive white Gaussian noise channel. For the case of completely known noise and signal powers, we set up a vector-matrix model for an OFDM signal with a cyclic prefix and derive the optimal Neyman-Pearson detector from first principles. For the case of completely unknown noise and signal powers, we derive a generalized likelihood ratio test (GLRT) based on empirical second-order statistics of the received data. The proposed GLRT detector exploits the non-stationary correlation structure of the OFDM signal and does not require any knowledge of the noise or signal powers.In the second paper, we create a unified framework for spectrum sensing of signals which have covariance matrices with known eigenvalue multiplicities. We derive the GLRT for this problem, with arbitrary eigenvalue multiplicities under both hypotheses. We also show a number of applications to spectrum sensing for cognitive radio.The general result of the second paper is used as a building block, in the third and fourth papers, for spectrum sensing of second-order cyclostationary signals received at multiple antennas and orthogonal space-time block coded (OSTBC) signals respectively. The proposed detector of the third paper exploits both the spatial and the temporal correlation of the received signal, from knowledge of the fundamental period of the cyclostationary signal and the eigenvalue multiplicities of the temporal covariance matrix.In the fourth paper, we consider spectrum sensing of signals encoded with an OSTBC. We show how knowledge of the eigenvalue multiplicities of the covariance matrix are inherent owing to the OSTBC, and propose an algorithm that exploits that knowledge for detection. We also derive theoretical bounds on the performance of the proposed detector. In addition, we show that the proposed detector is robust to a carrier frequency offset, and propose another detector that deals with timing synchronization using the detector for the synchronized case as a building block.A slightly different approach to covariance matrix estmation is taken in the fifth paper. We consider spectrum sensing of Gaussian signals with structured covariance matrices, and propose to estimate the unknown parameters of the covariance matrices using covariance matching estimation techniques (COMET). We also derive the optimal detector based on a Gaussian approximation of the sample covariance matrix, and show that this is closely connected to COMET.The last paper deals with the problem of discriminating samples that containonly noise from samples that contain a signal embedded in noise, when the variance of the noise is unknown. We derive the optimal soft decision detector using a Bayesian approach. The complexity of this optimal detector grows exponentially with the number of observations and as a remedy, we propose a number of approximations to it. The problem under study is a fundamental one andit has applications in signal denoising, anomaly detection, and spectrum sensing for cognitive radio.
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| 4. |
- Cirkic, Mirsad, et al.
(författare)
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Approximating the LLR Distribution for a Class of Soft-Output MIMO Detectors
- 2012
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Ingår i: IEEE Transactions on Signal Processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1053-587X .- 1941-0476. ; 60:12, s. 6421-6434
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Tidskriftsartikel (refereegranskat)abstract
- We present approximations of the LLR distribution for a class of fixed-complexity soft-output MIMO detectors, such as the optimal soft detector and the soft-output via partial marginalization detector. More specifically, in a MIMO AWGN setting, we approximate the LLR distribution conditioned on the transmitted signal and the channel matrix with a Gaussian mixture model (GMM). Our main results consist of an analytical expression of the GMM model (including the number of modes and their corresponding parameters) and a proof that, in the limit of high SNR, this LLR distribution converges in probability towards a unique Gaussian distribution.
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| 5. |
- Čirkić, Mirsad, 1984-, et al.
(författare)
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Gaussian Approximation of the LLR Distribution for the ML and Partial Marginalization MIMO detectors
- 2011
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Ingår i: Proceedings of the IEEE International Conference on Acoustics, Speech and SignalProcessing (ICASSP). - : IEEE conference proceedings. - 9781457705373 ; , s. 3232-3235
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Konferensbidrag (refereegranskat)abstract
- We derive a Gaussian approximation of the LLR distribution conditioned on the transmitted signal and the channel matrix for the soft-output via partial marginalization MIMO detector. This detector performs exact ML as a special case. Our main results consist of discussing the operational meaning of this approximation and a proof that, in the limit of high SNR, the LLR distribution of interest converges in probability towards a Gaussian distribution.
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| 6. |
- Lundgren, Markus, et al.
(författare)
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Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
- 2014
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X. ; 15:7, s. 494-501
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
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| 7. |
- Nilsson, Anna-Lena, et al.
(författare)
-
Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children
- 2013
-
Ingår i: Viral Immunology. - : Mary Ann Liebert Inc. - 0882-8245 .- 1557-8976. ; 26:3, s. 207-215
-
Tidskriftsartikel (refereegranskat)abstract
- Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL and 4th quartile LVAb were found in 25% (170/676) of which 64% were < 10 (n = 108, p < 0.0001), and 27% were < 5 (n = 45; p < 0.0001) years old. The 4th quartile LVAb in children < 10 years of age correlated to HLA DQ2/8, 8/8, and 8/X (p < 0.0001). Furthermore, in the group with 4th quartile LVAb, 55% were IAA positive (p = 0.01) and correlation was found between 4th quartile LVAb and IAA in children < 10 years of age (p = 0.035). It is concluded that 1) LVAb were common among the young T1D patients and LVAb levels were higher in the younger age groups; 2) 4th quartile LVAb correlated with IAA; and 3) there was a correlation between 4th quartile LVAb and HLA-DQ8, particularly in the young patients. The presence of LVAb supports the notion that prior exposure to LV may be associated with T1D.
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| 8. |
- Abidin, Aysajan, 1983-
(författare)
-
Authentication in Quantum Key Distribution : Security Proof and Universal Hash Functions
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Quantum Key Distribution (QKD) is a secret key agreement technique that consists of two parts: quantum transmission and measurement on a quantum channel, and classical post-processing on a public communication channel. It enjoys provable unconditional security provided that the public communication channel is immutable. Otherwise, QKD is vulnerable to a man-in-the-middle attack. Immutable public communication channels, however, do not exist in practice. So we need to use authentication that implements the properties of an immutable channel as well as possible. One scheme that serves this purpose well is the Wegman-Carter authentication (WCA), which is built upon Almost Strongly Universal2 (ASU2) hashing. This scheme uses a new key in each authentication attempt to select a hash function from an ASU2 family, which is then used to generate the authentication tag for a message.The main focus of this dissertation is on authentication in the context of QKD. We study ASU2 hash functions, security of QKD that employs a computationally secure authentication, and also security of authentication with a partially known key. Specifically, we study the following.First, Universal hash functions and their constructions are reviewed, and as well as a new construction of ASU2 hash functions is presented. Second, security of QKD that employs a specific computationally secure authentication is studied. We present detailed attacks on various practical implementations of QKD that employs this authentication. We also provide countermeasures and prove necessary and sufficient conditions for upgrading the security of the authentication to the level of unconditional security. Third, Universal hash function based multiple authentication is studied. This uses a fixed ASU2 hash function followed by one-time pad encryption, to keep the hash function secret. We show that the one-time pad is necessary in every round for the authentication to be unconditionally secure. Lastly, we study security of the WCA scheme, in the case of a partially known authentication key. Here we prove tight information-theoretic security bounds and also analyse security using witness indistinguishability as used in the Universal Composability framework.
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| 9. |
- Abidin, Aysajan, et al.
(författare)
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Direct proof of security of Wegman-Carter authentication with partially known key
- 2014
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Ingår i: Quantum Information Processing. - : Springer. - 1570-0755 .- 1573-1332. ; 13:10, s. 2155-2170
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Tidskriftsartikel (refereegranskat)abstract
- Information-theoretically secure (ITS) authentication is needed in Quantum Key Distribution (QKD). In this paper, we study security of an ITS authentication scheme proposed by Wegman& Carter, in the case of partially known authentication key. This scheme uses a new authentication key in each authentication attempt, to select a hash function from an Almost Strongly Universal2 hash function family. The partial knowledge of the attacker is measured as the trace distance between the authentication key distribution and the uniform distribution; this is the usual measure in QKD. We provide direct proofs of security of the scheme, when using partially known key, first in the information-theoretic setting and then in terms of witness indistinguishability as used in the Universal Composability (UC) framework. We find that if the authentication procedure has a failure probability ε and the authentication key has an ε´ trace distance to the uniform, then under ITS, the adversary’s success probability conditioned on an authentic message-tag pair is only bounded by ε +|Ƭ|ε´, where |Ƭ| is the size of the set of tags. Furthermore, the trace distance between the authentication key distribution and the uniform increases to |Ƭ|ε´ after having seen an authentic message-tag pair. Despite this, we are able to prove directly that the authenticated channel is indistinguishable from an (ideal) authentic channel (the desired functionality), except with probability less than ε + ε´. This proves that the scheme is (ε + ε´)-UC-secure, without using the composability theorem.
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| 10. |
- Abidin, Aysajan, et al.
(författare)
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New Universal Hash Functions
- 2012
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Ingår i: Lecture Notes in Computer Science, Vol. 7242. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783642341588 - 9783642341595 ; , s. 99-108
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Konferensbidrag (refereegranskat)abstract
- Universal hash functions are important building blocks for unconditionally secure message authentication codes. In this paper, we present a new construction of a class of Almost Strongly Universal hash functions with much smaller description (or key) length than the Wegman-Carter construction. Unlike some other constructions, our new construction has a very short key length and a security parameter that is independent of the message length, which makes it suitable for authentication in practical applications such as Quantum Cryptography.
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