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Träfflista för sökning "WFRF:(Larsson L) srt2:(1980-1989)"

Sökning: WFRF:(Larsson L) > (1980-1989)

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  • Ohlson, Sten, et al. (författare)
  • High Performance Liquid Affinity Chromatography: a New Tool in Biotechnology
  • 1989
  • Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 7:7, s. 179-186
  • Tidskriftsartikel (refereegranskat)abstract
    • In high performance liquid affinity chromatography (HPLAC), the biospecificity of affinity chromatography is combined with the robust support materials of HPLC. HPLAC can provide specificity, speed and high resolution in chromatography both on analytical and preparative scales. The number of commercially available HPLAC matrices is an indicator of the growing use of the technique. 
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  • Belew, M, et al. (författare)
  • Structure-activity studies on synthetic analogs to vasoactive peptides derived from human fibrinogen.
  • 1980
  • Ingår i: Biochimica et Biophysica Acta. - 0006-3002 .- 1878-2434. ; 632:1, s. 87-94
  • Tidskriftsartikel (refereegranskat)abstract
    • Counterparts to two vasoactive peptides previously isolated from fibrin(ogen) degraded by plasmin (EC 3.4.21.7) were synthesized by the solid phase procedure. The synthetic undecapeptide (Ser-Gln-Leu-Gln-Lys-Val-Pro-Pro-Glu-Trp-Lys) was isolated in a homogeneous state by chromatography on Sephadex G-25 and DEAE-Sepharose CL-6B and the pentapeptide (Ala-Arg-Pro-Ala-Lys) by chromatography on BioGel P-6 and column zone electrophoresis. The effect of these two peptides and of fifteen analogs to the pentapeptide on microvascular permeability in rat skin was investigated. The two synthetic counterparts were as potent as the natural peptides. With respect to the analogs, the influence of different functional groups was first studied. This was followed by attempts to minimize the active structure, induce or relieve rigidity of the peptide back-bone or otherwise accomplish modifications by a change in chirality at critical positions. Our results show that the tetrapeptide Arg-Pro-Ala-Lys has the same effect on microvascular permeability as the pentapeptide in the assay system used. Basic amino acids at both ends, as well as a proline residue adjacent to the N-terminal amino acid appear important for full or essentially full activity. On the other hand, substitution of the Ala at position 4 with several other amino acids did not result in a significant loss in biological potency.
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  • Bjornstad, T., et al. (författare)
  • Study of the Giant Gamow-Teller Resonance in Nuclear Beta-Decay - the Case of Ar-32
  • 1985
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 443:2, s. 283-301
  • Tidskriftsartikel (refereegranskat)abstract
    • Delayed proton and gamma emissions following the β-decay of 32Ar have been studied. The half-life of 32Ar is 98 ± 2 ms, and the T = 2 analogue state in 32Cl lies at the excitation energy 5036 ± 12 keV. From the intensity of the feeding to this state the proton intensities can be converted to an absolute scale leading to a total proton branching ratio of (43 ± 3)%. From proton-gamma coincidence measurements it emerges that (1.9 ± 0.2)% of the protons lead to the first-excited state in 31S. A level scheme up to 8.75 MeV excitation in 32Cl has been constructed and the Gamow-Teller strength function has been deduced. The result is a renormalization of the axial-vector strength to (49 ± 5)% of the free-nucleon value.
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  • Glad, M, et al. (författare)
  • Separation Agent
  • 1983
  • Patent (populärvet., debatt m.m.)
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