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- amundsen, silja, et al.
(författare)
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A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families.
- 2007
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Ingår i: European Journal of Human genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 15:9, s. 980-987
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Tidskriftsartikel (refereegranskat)abstract
- Celiac disease (CD) is a gluten-induced enteropathy, which results from the interplay between environmental and genetic factors. There is a strong human leukocyte antigen (HLA) association with the disease, and HLA-DQ alleles represent a major genetic risk factor. In addition to HLA-DQ, non-HLA genes appear to be crucial for CD development. Chromosomal region 5q31–33 has demonstrated linkage with CD in several genome-wide studies, including in our Swedish/Norwegian cohort. In a European meta-analysis 5q31–33 was the only region that reached a genome-wide level of significance except for the HLA region. To identify the genetic variant(s) responsible for this linkage signal, we performed a comprehensive single nucleotide polymorphism (SNP) association screen in 97 Swedish/Norwegian multiplex families who demonstrate linkage to the region. We selected tag SNPs from a 16 Mb region representing the 95% confidence interval of the linkage peak. A total of 1404 SNPs were used for the association analysis. We identified several regions with SNPs demonstrating moderate single- or multipoint associations. However, the isolated association signals appeared insufficient to account for the linkage signal seen in our cohort. Collective effects of multiple risk genes within the region, incomplete genetic coverage or effects related to copy number variation are possible explanations for our findings.
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| 2. |
- Larsson, Oscar, 1978-
(författare)
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Polarization characteristics in polyelectrolyte thin film capacitors : Targeting field-effect transistors and sensors
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Polymers are very attractive materials that can be tailored for specific needs and functionality. They can for instance be made electrically insulating or (semi)conducting, with specific mechanical properties. Polymers are often processable from a solution, which enables the use of low-cost manufacturing techniques to fabricate polymer devices. Polymer-based electronic and electrochemical devices and sensors have been developed.This thesis is related to the polarization characteristics in polyelectrolyte thin film capacitor structures. The polarization characteristics have been analyzed at various humidity levels for polyelectrolyte capacitors alone and when incorporated as the gate-insulating material in polyelectrolyte-gated organic field-effect transistors. Both limitations and possibilities of this class of transistors have been identified. Also, a concept for wireless readout of a passively operated humidity sensor circuit is demonstrated. The sensing mechanism of this sensor is related to the polarization in a polyelectrolyte thin film capacitor. This sensor circuit can be manufactured entirely with common printing technologies of today and can be integrated into a low-cost passive sensor label.
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| 3. |
- Papmehl-Dufay, Ludvig, 1976-
(författare)
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Shaping an identity : Pitted Ware pottery and potters in southeast Sweden
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis is concerned with pottery and culture during the Middle Neolithic (c. 3300 – 2300 cal BC) in southeast Sweden. Its purpose is to investigate and discuss the significance of pottery in the Pitted Ware culture, particularly on the island of Öland in the Baltic Sea. The history of research concerning this subject area is recounted and the known Neolithic remains from the island of Öland are reviewed. The two Pitted Ware sites so far excavated on the island, Köpingsvik and Ottenby Royal Manor, are presented in detail, and ceramics from these two sites are used in the pottery analysis that makes up the empirical core of the work. The assemblages are approached by similar methods and by posing similar questions, and the analytical methods used include recording of the large ceramic assemblages (aspects of design), microscopic analysis of ceramic thin sections and raw clay samples (aspects of raw material use and pottery technology) and lipid residue analysis performed on extracts from pulverised ceramic ware (aspects of pottery use). The results clearly point to a rather elaborate and socially embedded ceramic craft tradition, with a strong preference for decorated vessels and clearly defined ideas on how the pots should be produced and what they should look like. The technological analysis revealed a rather complicated and restrictive raw material situation, with which the potters coped partly by developing local tempering traditions. The functional analysis revealed a striking variability in pottery use between the two sites. The various differences in pottery observed between the two sites are discussed in terms of local sub-traditions within the overall Pitted Ware ceramic tradition, that may have developed through the work of individual potters and contacts with different areas and groups of people. In this way an attempt is made to view pottery and the ceramic craft in the Pitted Ware culture from a more dynamic perspective.
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