| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Allentoft, Morten E., et al.
(författare)
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Population genomics of post-glacial western Eurasia
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 301-311
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Tidskriftsartikel (refereegranskat)abstract
- Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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| 3. |
- Engström, Gunnar, et al.
(författare)
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Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications
- 2024
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Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 39:1, s. 35-49
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Tidskriftsartikel (refereegranskat)abstract
- Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
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| 4. |
- Delanaye, Pierre, et al.
(författare)
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Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil, and Africa.
- 2022
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385.
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A new Chronic Kidney Disease Epidemiology equation without race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared to the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.METHODS: Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France, (n = 4429, including 964 Black Europeans), from Brazil (n = 100), and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed.RESULTS: In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of -0.6 and -3.2, respectively versus 5.0 mL/min/1.73m², and accuracy within 30% of 86.9 and 87.4, respectively versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value ( = concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans, and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males.CONCLUSION: In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated, population-specific Q-values presents the best performance in the whole age range in the European and African populations included in this study.
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| 5. |
- Delanaye, Pierre, et al.
(författare)
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Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
- 2022
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Ingår i: British Journal of Clinical Pharmacology. - : Wiley-Blackwell Publishing Inc.. - 0306-5251 .- 1365-2125. ; 88:5, s. 2118-2127
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing METHODS: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14,804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR), and European-Kidney-Function-Consortium (EKFC) equations. Validation focused on bias, imprecision, and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age, and body mass index at mGFR <60 mL/min, as well as classification in mGFR stages.RESULTS: The CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD-EPI, but worse than LMR and EKFC. In subjects with mGFR<60 mL/min and at BMI [18.5-25[kg/m2 , all equations performed similarly and for BMI<18.5kg/m2 CG and LMR had the best results though all equations had poor P30-accuracy. At BMI≥25kg/m2 the bias of the CG increased with increasing BMI (+17.2mL/min at BMI≥40kg/m2 ). The four more recent equations also classified mGFR stages better than CG.CONCLUSIONS: The CG equation showed poor ability to estimate GFR overall and in analyses stratified for GFR, age, and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine-based equations.
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| 6. |
- Dwibedi, Chinmay Kumar, et al.
(författare)
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Biological amplification of low frequency mutations unravels laboratory culture history of the bio-threat agent Francisella tularensis
- 2020
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Ingår i: Forensic Science International. - : Elsevier. - 1872-4973 .- 1878-0326. ; 45
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Tidskriftsartikel (refereegranskat)abstract
- Challenges of investigating a suspected bio attack include establishing if microorganisms have been cultured to produce attack material and to identify their source. Addressing both issues, we have investigated genetic variations that emerge during laboratory culturing of the bacterial pathogen Francisella tularensis. Key aims were to identify genetic variations that are characteristic of laboratory culturing and explore the possibility of using biological amplification to identify genetic variation present at exceedingly low frequencies in a source sample. We used parallel serial passage experiments and high-throughput sequencing of F. tularensis to explore the genetic variation. We found that during early laboratory culture passages of F. tularensis, gene duplications emerged in the pathogen genome followed by single-nucleotide polymorphisms in genes for bacterial capsule synthesis. Based on a biological enrichment scheme and the use of high-throughput sequencing, we identified genetic variation that likely pre-existed in a source sample. The results support that capsule synthesis gene mutations are common during laboratory culture, and that a biological amplification strategy is useful for linking a F. tularensis sample to a specific laboratory variant among many highly similar variants.
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| 7. |
- Lagnelöv, Oscar, et al.
(författare)
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Cost analysis of autonomous battery electric field tractors in agriculture
- 2021
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Ingår i: Biosystems Engineering. - : Elsevier. - 1537-5110 .- 1537-5129. ; 204, s. 358-376
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Tidskriftsartikel (refereegranskat)abstract
- Interest in the electrification of agricultural vehicles is increasing along with growing interest in autonomous vehicles. Individual technologies have been well-explored, but not their combined use and the effects on agricultural fieldwork. In this study, cost analysis was conducted based on a simulated vehicle system with 50 kW self-driving battery electric drive (BED) tractors. The analysis included battery degradation due to cycling and the cost of inadequate machine capacity, as these factors are suspected to be problems for electric tractors. A dynamic discrete-event vehicle system model, a linear timeliness model and a one-dimensional battery cell ageing model were assumed. Costs obtained were compared with those of contemporary manned diesel-based systems. BED systems had equal or lower annual costs compared to conventional manned diesel-based systems; this was due to lower costs for fuel and maintenance, while providing adequate capacity and lower energy usage. Sensitivity analysis showed that operating costs were of greater significance than investment costs. The generally more expensive investment costs of BED systems were outweighed by the reduced operating costs for several different BED system systems. Battery degradation costs and timeliness were influential, but not sufficient to make the system uncompetitive. The synergistic effect of vehicular autonomy and BED outweighed several of the drawbacks of BED systems, such as frequent recharging, increased transport and reduced consecutive work time.
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| 8. |
- Lagnelöv, Oscar, et al.
(författare)
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Electric tractors – Sustainable and Profitable? Economic and environmental impact of autonomy and electric drivelines in agriculture
- 2022
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Ingår i: VDI reports. - : VDI Verlag. ; , s. 189-196
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Konferensbidrag (refereegranskat)abstract
- Vehicle electrification can be an effective emission-mitigating technology in heavy vehicles, including in agriculture. Simulation was used to assess the effect of switching conventional diesel tractors to multiple lighter autonomous battery-electric tractors on a Swedish grain farm. An autonomous diesel tractor was also considered. An LCA was made to assess environmental impacts, and the annual cost was calculated. The electric scenario had a 65% lower climate impact than its diesel counterpart and had a reduced the annual cost by lowering operator, fuel and maintenance cost. In total, the cost was lowered by 31% from the conventional scenario. In both the environmental impact and cost, fuel played an important role.
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| 9. |
- Lagnelöv, Oscar, et al.
(författare)
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Impact of lowered vehicle weight of electric autonomous tractors in a systems perspective
- 2023
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Ingår i: Smart agricultural technology. - : Elsevier BV. - 2772-3755. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Modern agriculture rely on heavy machinery that has increased risk of detrimental soil compaction of arable fields. This can lead to negative effects such as reduced yields, reduced field trafficability and increased fuel use. Electric, autonomous tractors makes it possible to replace one heavy machine with several lighter without increased labour costs. In this study, the economic and environmental effects of reduced soil compaction for smaller autonomous tractors were assessed and compared to a scenario with conventional tractors. A discrete event simulation of a Swedish 200 ha grain farm with clay soil was used for the calculations. The electric, autonomous system had lower soil compaction impacts as well as other benefits, and reduced cost in total from 385 to 258 euro ha-1 and the climate impact from 270 to 77 kg CO2eq ha-1 compared to the conventional scenario. Soil compaction constituted 20% of the cost and 26% of the climate impact for the conventional scenario. It was concluded that soil compaction was impactful in machinery studies, especially on heavier soil like clay, and should not be omitted. Soil compaction avoidance alone was not impactful enough to warrant a change to electric, autonomous tractors but it reinforced already existing trends and further improved the cost and environmental benefits.
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| 10. |
- Lagnelöv, Oscar, et al.
(författare)
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Life Cycle Assessment of Autonomous Electric Field Tractors in Swedish Agriculture
- 2021
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- There is an increased interest for battery electric vehicles in multiple sectors, including agriculture. The potential for lowered environmental impact is one of the key factors, but there exists a knowledge gap between the environmental impact of on-road vehicles and agricultural work machinery. In this study, a life cycle assessment was performed on two smaller, self-driving battery electric tractors, and the results were compared to those of a conventional tractor for eleven midpoint characterisation factors, three damage categories and one weighted single score. The results showed that compared to the conventional tractor, the battery electric tractor had a higher impact in all categories during the production phase, with battery production being a majority contributor. However, over the entire life cycle, it had a lower impact in the weighted single score (-72%) and all three damage categories; human health (-74%), ecosystem impact (-47%) and resource scarcity (-67%). The global warming potential over the life cycle of the battery electric tractor was 102 kg CO(2)eq.ha(-1) y(-1) compared to 293 kg CO(2)eq.ha(-1) y(-1) for the conventional system. For the global warming potential category, the use phase was the most influential and the fuel used was the single most important factor.
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