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1.	Engström, Gunnar, et al. (författare) Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications 2024 Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 39:1, s. 35-49 Tidskriftsartikel (refereegranskat)abstract Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
2.	Ohlsson, Claes, 1965, et al. (författare) Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical trial 2020 Ingår i: EClinicalMedicine. - : Elsevier BV. - 2589-5370. ; 22 Tidskriftsartikel (refereegranskat)abstract Background: Recently we provided evidence for a leptin-independent homeostatic regulation, the gravitostat, of body weight in rodents. The aim of the present translational proof of concept study was to test the gravitostat hypothesis in humans. Methods: We conducted a randomized controlled single center trial (ClinicalTrial.gov number, NCT03672903), to evaluate the efficacy of artificially increased weight loading on body weight in subjects with mild obesity (BMI 30–35 kg/m2). Subjects were either treated with a heavy (=high load; 11% of body weight) or light (=low load; 1% of body weight) weight vest for eight hours per day for three weeks. The primary outcome was change in body weight. Secondary outcomes included change in body fat mass and fat-free mass as measured using bioelectrical impedance analysis. Findings: In total 72 participants underwent randomization and 69 (36 high load and 33 low load) completed the study for the primary outcome. High load treatment resulted in a more pronounced relative body weight loss compared to low load treatment (mean difference -1.37%, 95% confidence interval (CI), -1.96 to -0.79; p = 1.5 × 10−5). High load treatment reduced fat mass (-4.04%, 95% CI, -6,53 to -1.55; p = 1.9 × 10−3) but not fat free mass (0.43%, 95% CI, -1.47 to 2.34; p = 0.65) compared to low load treatment. Interpretation: Increased weight loading reduces body weight and fat mass in obese subjects in a similar way as previously shown in obese rodents. These findings demonstrate that there is weight loading dependent homeostatic regulation of body weight, the gravitostat, also in humans. Funding: Funded by Jane and Dan Olsson (JADO) Foundation, the Torsten Söderberg Foundation, The Knut and Alice Wallenberg's Foundation and the Novo Nordisk Foundation. © 2020 The Author(s)

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Engström, Gunnar (1); Wollmer, Per (1); Lampa, Erik, 1977- (1); Janzon, Magnus (1); Gummesson, Anders, 1 ... (1); Jansson, Per-Anders, ... (1); visa fler...; Bergström, Göran, 19 ... (1); Ahlström, Håkan, 195 ... (1); Lind, Lars (1); Waldenström, Anders (1); Persson, Margaretha (1); Rosengren, Annika, 1 ... (1); Ohlsson, Claes, 1965 (1); Persson, Anders (1); Sundström, Johan, Pr ... (1); Schmidt, Caroline, 1 ... (1); Engvall, Jan (1); Ahlm, Kristin (1); Persson, Lennart (1); Hagström, Emil (1); Fall, Tove, 1979- (1); Blomberg, Anders, 19 ... (1); Caidahl, Kenneth (1); Lindberg, Eva (1); Alfredsson, Joakim (1); Jernberg, Tomas (1); Söderberg, Stefan (1); Swahn, Eva (1); Dekkers, Koen (1); Gigante, Bruna (1); Mannila, Maria (1); Larsson, Christel, 1 ... (1); Jansson, John-Olov, ... (1); Gidestrand, Edwin (1); Palsdottir, Vilborg, ... (1); Bellman, Jakob (1); Nilsson, Ulf, 1974- (1); Eriksson, Maria J. (1); Johnson, Linda (1); Lin, Yi-Ting, 1981- (1); Östgren, Carl Johan (1); Hägg, Daniel, 1974 (1); Hedner, Jan (1); Brandberg, John, 196 ... (1); Cederlund, Kerstin (1); Skoglund Larsson, Li ... (1); Duvernoy, Olov (1); Torén, Kjell (1); Zaigham, Suneela (1); Hamrefors, Viktor (1); visa färre...

Lärosäte: Göteborgs universitet (2); Umeå universitet (1); Uppsala universitet (1); Linköpings universitet (1); Lunds universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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