| 1. |
- Chirumalla, Koteshwar, et al.
(author)
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Knowledge Sharing Across Boundaries : Web 2.0 and Product-Service System Development
- 2011
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In: 3rd International Conference on Research into Design ICoRD'11. - Bangalore, India : Research Publishing Services. - 9789810877217
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Conference paper (peer-reviewed)abstract
- In recent years there has been a growing interest among product development organizations to capitalize on engineering knowledge as their core competitive advantage for innovation. Capturing, storing, retrieval, sharing and reusing of engineering knowledge from a wide range of enterprise memory systems have become crucial activities of knowledge management practice in competitive organizations. In light of a changing and dynamic enterprise definition, including a move towards Product-Service System (PSS) development, this paper discusses some of the limitations of current enterprise systems in reusing engineering knowledge across functional and corporate boundaries. Further, the paper illustrates how Web 2.0-based collaborative technologies can leverage cross-functional knowledge for new PSS development projects through an open, bottom-up, and collective sense-making approach to knowledge management.
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| 2. |
- Benaim, Andre, et al.
(author)
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Becoming An Innovative Company : Assessing An Organization’s Innovation Capability From The Perspective Of A Team
- 2014
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Conference paper (peer-reviewed)abstract
- Literature points out the need for companies to innovate continuously. Such need requires that companies develop capacities to exploit and improve current work as well as to develop and explore more radical opportunities. This paper is a case study that investigates the innovation capabilities of a multinational manufacturing company by interviewing a group that is mandate to support the development of those capabilities. The data was collected by semi-structured interviews, which were based on the categories of a framework previously developed. The findings speak about the importance of setting clear processes for continuation and implementation of ideas, adequate allocation of resources and management support. The discussion and conclusion are about the importance of the integration of efforts in different organizational levels and some of the future challenges integrating the innovation efforts into a natural way of working.
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| 3. |
- Benaim, Andre, et al.
(author)
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Building a pathway for innovation : Lessons learned from developing an online platform
- 2014
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In: Proceedings of NordDesign 2014 Conference, NordDesign 2014. - Eespo, Finland : Aalto University. - 9781904670582 ; , s. 662-669
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Conference paper (peer-reviewed)abstract
- Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in terms of innovation process, climate, and capabilities. The results show that the platform itself is not enough for innovation. The structure and work processes around the platform are as important, which implies the need to design processes and procedures that allow an idea to develop, providing, focus, idea feedback and role clarity.
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| 4. |
- Bertoni, Marco, et al.
(author)
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The Rise of Social Product Development
- 2012
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In: International Journal of Networking and Virtual Organisations. - Australia : Inderscience Publishers. - 1741-5225 .- 1470-9503. ; 11:2, s. 188-207
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Journal article (peer-reviewed)abstract
- The aim of the paper is to discuss the rising potential of social software to increase the knowledge management capabilities of virtual product development teams. It presents six fundamental transitions, elaborated from the empirical findings, which justify the rise of a more bottom-up, social creation and sharing of engineering knowledge in the virtual organisation. The study suggests that traditional engineering knowledge management approaches alone are not sufficient to support development activities in the virtual organisation, and that such teams display an increasing demand for social, comparatively lightweight and remixable platforms for bottom-up, social creation and sharing of knowledge.
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| 5. |
- Carlsson, Axel C, et al.
(author)
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Soluble TNF receptors and kidney dysfunction in the elderly
- 2014
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In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 25:6, s. 1313-1320
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Journal article (peer-reviewed)abstract
- The importance of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in the development of kidney disease is being unraveled. Yet, community-based data regarding the role of sTNFRs are lacking. We assessed serum sTNFRs and aspects of kidney damage cross-sectionally in two independent community-based cohorts of elderly participants: Prospective Investigation of the Vasculature in Uppsala Seniors (n=815; mean age, 75 years; 51% women) and Uppsala Longitudinal Study of Adult Men (n=778; mean age, 78 years). Serum sTNFR1 correlated substantially with different aspects of kidney pathology in the Uppsala Longitudinal Study of Adult Men cohort (R=-0.52 for estimated GFR, R=0.22 for urinary albumin-to-creatinine ratio, and R=0.17 for urinary kidney injury molecule-1; P<0.001 for all), with similar correlations in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort. These associations remained significant after adjustment for age, sex, inflammatory markers, and cardiovascular risk factors and were also evident in participants without diabetes. Serum sTNFR2 was associated with all three markers in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort (P<0.001 for all). Our findings from two independent community-based cohorts confirm and extend results of previous studies supporting circulating sTNFRs as relevant biomarkers for kidney damage and dysfunction in elderly individuals, even in the absence of diabetes.
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| 6. |
- Carlsson, Axel C, et al.
(author)
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Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes : findings from two community based cohorts of elderly
- 2014
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In: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 237:1, s. 236-242
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Journal article (peer-reviewed)abstract
- BACKGROUND: Experimental evidence support soluble receptors for tumor necrosis factor alpha as important mediators of the underlying pathology leading to cardiovascular disease and cancer. However, prospective data concerning the relation between circulating soluble tumor necrosis factor receptor-1 (sTNFR1) and mortality in humans are lacking. We aimed to explore and validate the association between sTNFR1 and mortality, and to explore the influence of other established risk factors for mortality, including other inflammatory markers.METHODS: The association between serum sTNFR1and the risk for mortality was investigated in two community-based cohorts of elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 50%, n = 1005, mean age 70 years, median follow-up 7.9 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 775, mean age 77 years, median follow-up 8.1 years).RESULTS: In total, 101 participants in PIVUS and 274 in ULSAM died during follow-up. In multivariable Cox regression models adjusted for inflammation, lifestyle and established cardiovascular risk factors, one standard deviation (SD) higher sTNFR1 was associated with a hazard ratio (HR) for mortality of 1.37, 95% confidence interval (CI) 1.17-1.60, in PIVUS and HR 1.22, 95% CI 1.10-1.37 in ULSAM. Moreover, circulatingsTNFR1 was associated with cardiovascular mortality (HR per SD of sTNFR1, 1.24, 95% CI 1.07-1.44) and cancer mortality (HR per SD of sTNFR1, 1.32, 95% CI 1.11-1.57) in the ULSAM cohort. High levels of sTNFR1 identified individuals with increased risk of mortality among those with high as well as low levels of systemic inflammation.CONCLUSIONS: An association between circulating sTNFR1 and an increased risk for mortality was found and validated in two independent community-based cohorts. The future clinical role of sTNFR1 to identify high risk patients for adverse outcomes and mortality has yet to be determined.
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| 7. |
- Carlsson, Axel C, et al.
(author)
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Urinary kidney injury molecule 1 and incidence of heart failure in elderly men
- 2013
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In: European Journal of Heart Failure. - : Oxford University Press. - 1388-9842 .- 1879-0844. ; 15:4, s. 447-446
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Journal article (peer-reviewed)abstract
- AIMS: There is growing recognition of the clinical importance of cardiorenal syndrome-the bidirectional interplay between kidney and cardiac dysfunction. Yet, the role of kidney tubular damage in the development of heart failure is less studied. The objective of this study was to investigate whether urinary kidney injury molecule (KIM)-1, a specific marker of tubular damage, predisposes to an increased heart failure risk.METHODS AND RESULTS: This was a community-based cohort study [Uppsala Longitudinal study of Adult Men (ULSAM)] of 565, 77-year-old men free from heart failure at baseline. Heart failure hospitalizations were used as outcome. During follow-up (median 8.0 years), 73 participants were hospitalized for heart failure. In models adjusted for cardiovascular risk factors (age, systolic blood pressure, diabetes, smoking, body mass index, LDL/HDL ratio, antihypertensive treatment, lipid-lowering treatment, aspirin treatment, LV hypertrophy, and prevalent cardiovascular disease) and markers of kidney dysfunction and damage [cystatin C-based glomerular filtration rate (GFR) and urinary albumin/creatinine ratio], a higher urinary KIM-1/creatinine ratio was associated with higher risk for heart failure (hazard ratio upper vs. lower tertile, 1.81; 95% confidence interval 1.01-3.29; P < 0.05). Participants with a combination of low GFR (<60 mL/min/1.72 m(2)) and high KIM-1/creatinine (>128 ng/mmol) had a 3-fold increase in heart failure risk compared with participants with normal GFR and KIM-1 (P < 0.001).CONCLUSION: Our findings suggest that kidney tubular damage predisposes to an increased risk for heart failure in the community. Further studies are needed to clarify the causal role of KIM-1 in the development of heart failure, and to evaluate the clinical utility of urinary KIM-1 measurements.
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| 8. |
- Carlsson, Axel C, et al.
(author)
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Urinary kidney injury molecule-1 and the risk of cardiovascular mortality in elderly men
- 2014
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In: American Society of Nephrology. Clinical Journal. - 1555-9041 .- 1555-905X. ; 9:8, s. 1393-1401
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Journal article (peer-reviewed)abstract
- BACKGROUND AND OBJECTIVES: Kidney injury molecule-1 (KIM-1) has been suggested as a clinically relevant highly specific biomarker of acute kidney tubular damage. However, community-based data on the association between urinary levels of KIM-1 and the risk for cardiovascular mortality are lacking. This study aimed to investigate the association between urinary KIM-1 and cardiovascular mortality.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a prospective study, using the community-based Uppsala Longitudinal Study of Adult Men (N=590; mean age 77 years; baseline period, 1997-2001; median follow-up 8.1 years; end of follow-up, 2008).RESULTS: During follow-up, 89 participants died of cardiovascular causes (incidence rate, 2.07 per 100 person-years at risk). Models were adjusted for cardiovascular risk factors (age, systolic BP, diabetes, smoking, body mass index, total cholesterol, HDL cholesterol, antihypertensive treatment, lipid-lowering treatment, aspirin treatment, and history of cardiovascular disease) and for markers of kidney dysfunction and damage (cystatin C-based eGFR and urinary albumin/creatinine ratio). Higher urinary KIM-1/creatinine (from 24-hour urine collections) was associated with a higher risk for cardiovascular mortality (hazard ratio per SD increase, 1.27; 95% confidence interval [95% CI], 1.05 to 1.54; P=0.01). Participants with a combination of high KIM-1/creatinine (upper quintile, ≥175 ng/mmol), low eGFR (≤60 ml/min per 1.73 m(2)), and microalbuminuria/macroalbuminuria (albumin/creatinine ratio≥3 g/mol) had a >8-fold increased risk compared with participants with low KIM-1/creatinine (<175 ng/mmol), normal eGFR (>60 ml/min per 1.73 m(2)), and normoalbuminuria (albumin/creatinine ratio<3 g/mol) (hazard ratio, 8.56; 95% CI, 4.17 to 17.56; P<0.001).CONCLUSIONS: These findings suggest that higher urinary KIM-1 may predispose to a higher risk of cardiovascular mortality independently of established cardiovascular risk factors, eGFR, and albuminuria. Additional studies are needed to further assess the utility of measuring KIM-1 in the clinical setting.
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| 9. |
- Chirumalla, Koteshwar, et al.
(author)
-
Knowledge Sharing Across Boundaries:Web 2.0 and Product-Service System Development
- 2011
-
Conference paper (peer-reviewed)abstract
- In recent years there has been a growing interest among product development organizations to capitalize on engineering knowledge as their core competitive advantage for innovation. Capturing, storing, retrieval and sharing of engineering knowledge from a wide range of enterprise memory systems has become crucial part of knowledge management practice among competitive organizations. Managing and reusing their knowledge can facilitate design engineers to make more timely and informed decisions, thus reducing the decision loops for new innovation projects. In light of a changing and dynamic enterprise definition, including a move towards Product-Service System (PSS) development, this paper discusses some of the limitations of current enterprise memory systems in reusing engineering knowledge across the proposed knowledge life cycle. Further, the paper illustrates how Web 2.0-based collaborative technologies can leverage cross-functional knowledge for new PSS development projects through an open, bottom-up, and collective sens-emaking approach to knowledge management.
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| 10. |
- Ericson, Åsa, et al.
(author)
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Expanding the social dimension - Towards a knowledge base for product-service innovation
- 2011
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In: Impacting society through engineering design. - Glasgow : Design Research Society. - 9781904670230 ; , s. 143-152
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Conference paper (peer-reviewed)abstract
- The extension of businesses to incorporate the provision of function as a service in supplement to standalone products is an ongoing movement in manufacturing industry. In short, this means that the development intent should be guided by the need of ‘performance in use’ that the customer wants, e.g. thrust rather than an engine. By this, the established knowledge base challenges the development team. This paper embarks from the assumption that there are three main challenges, i.e. (1) innovation activities, (2) customer data acquisition and (3) the transformation of data into design information. The purpose is to discuss knowledge sharing activities to contribute to product-service innovation. In this study it has been found that contemporary data acquisition activities filter out important dimensions of knowledge. Thus, does not provide a sound base for service provisions.
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