Sökning: WFRF:(Larsson Tomas A. 1978 )
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Evolution of NETosi...
Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients
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- Huckriede, Joram (författare)
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
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- Bülow Anderberg, Sara (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Morales, Albert (författare)
- Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, and BCLC, CIBEREHD, Barcelona, Spain
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- de Vries, Femke (författare)
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
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- Hultström, Michael, 1978- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Bergqvist, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för medicinsk biokemi och mikrobiologi
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- Ortiz-Pérez, José T (författare)
- Cardiology Department, Hospital Clinic Barcelona and CIBERCV, Barcelona, Spain
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- Sels, Jan Willem (författare)
- Department of Intensive Care Medicine, Maastricht University Medical Centre MUMC+), Maastricht, the Netherlands
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- Wichapong, Kanin (författare)
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
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- Lipcsey, Miklos (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- van de Poll, Marcel (författare)
- Department of Intensive Care Medicine, Maastricht University Medical Centre MUMC+), Maastricht, the Netherlands
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Luther, Tomas, 1981- (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Reutelingsperger, Chris (författare)
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
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- de Frutos, Pablo Garcia (författare)
- Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS and CIBERCV, Barcelona, Spain
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- Frithiof, Robert (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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- Nicolaes, Gerry A F (författare)
- Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands
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Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, PO. Box 616, 6200 MD, Maastricht, the Netherlands Anestesiologi och intensivvård (creator_code:org_t)
- 2021-08-03
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associated molecular patterns (DAMPS) cell free DNA (cfDNA), extracellular histone H3 (H3) and neutrophil elastase (NE), and the immune modulators GAS6 and AXL in relation to clinical parameters, ICU scoring systems and mortality in patients (n = 100) with severe COVID-19. cfDNA, H3, NE, GAS6 and AXL were increased in COVID-19 patients compared to controls. These measures associated with occurrence of clinical events and intensive care unit acquired weakness (ICUAW). cfDNA and GAS6 decreased in time in patients surviving to 30 days post ICU admission. A decrease of 27.2 ng/mL cfDNA during ICU stay associated with patient survival, whereas levels of GAS6 decreasing more than 4.0 ng/mL associated with survival. The presence of H3 in plasma was a common feature of COVID-19 patients, detected in 38% of the patients at ICU admission. NETosis markers cfDNA, H3 and NE correlated well with parameters of tissue damage and neutrophil counts. Furthermore, cfDNA correlated with lowest p/f ratio and a lowering in cfDNA was observed in patients with ventilator-free days.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Acute inflammation
- Disease-free survival
- Infection
- Neutrophils
- Respiratory tract diseases
- Sepsis
- Viral infection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Huckriede, Joram
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Bülow Anderberg, ...
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Morales, Albert
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de Vries, Femke
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Hultström, Micha ...
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Bergqvist, Ander ...
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Ortiz-Pérez, Jos ...
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Sels, Jan Willem
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Wichapong, Kanin
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Lipcsey, Miklos
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van de Poll, Mar ...
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Larsson, Anders
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Luther, Tomas, 1 ...
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Reutelingsperger ...
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de Frutos, Pablo ...
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Frithiof, Robert
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Nicolaes, Gerry ...
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