| 1. |
- Lunnan, Ragnhild, et al.
(författare)
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Hydrogen-poor Superluminous Supernovae from the Pan-STARRS1 Medium Deep Survey
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 852:2
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Tidskriftsartikel (refereegranskat)abstract
- We present light curves and classification spectra of 17 hydrogen-poor superluminous supernovae (SLSNe) from the Pan-STARRS1 Medium Deep Survey (PS1 MDS). Our sample contains all objects from the PS1. MDS sample with spectroscopic classification that are similar to either of the prototypes SN 2005ap or SN 2007bi, without an explicit limit on luminosity. With a redshift range 0.3 < z < 1.6, PS1. MDS is the first SLSN sample primarily probing the high-redshift population; our multifilter PS1 light curves probe the rest-frame UV emission, and hence the peak of the spectral energy distribution. We measure the temperature evolution and construct bolometric light curves, and find peak luminosities of (0.5-5) x 10(44) erg s(-1) and lower limits on the total radiated energies of (0.3-2) x 10(51) erg. The light curve shapes are diverse, with both rise and decline times spanning a factor of similar to 5 and several examples of double-peaked light curves. When correcting for the flux-limited nature of our survey, we find a median peak luminosity at 4000 angstrom of M-4000 = -21.1 mag and a spread of sigma = 0.7 mag.
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| 2. |
- Scandariato, G., et al.
(författare)
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CHEOPS (CHaracterizing ExOPlanets Satellite) Mission
- 2016
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Ingår i: Proceedings of Science. - 1824-8039. ; 2016-May
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Tidskriftsartikel (refereegranskat)abstract
- The Characterizing ExOPlanet Satellite (CHEOPS) mission was selected in October 2012 by ESA as the first small mission. It will be a ultra-high precision photometer dedicated to the observation of transits of known exoplanets on bright stars, for which the mass has already been measured via ground-based spectroscopic surveys. Its precision will allow the accurate determination of the planetary radii and, by consequence, the planetary bulk density. CHEOPS will also unveil transiting exoplanets of interest for in-depth characterization, a legacy for future instruments suited to the spectroscopic characterization of exoplanetary atmospheres.
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| 3. |
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| 4. |
- Laskar, Ruhina S, et al.
(författare)
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Sex specific associations in genome wide association analysis of renal cell carcinoma.
- 2019
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 27:10, s. 1589-1598
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Tidskriftsartikel (refereegranskat)abstract
- Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.
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| 5. |
- Arseneault, M, et al.
(författare)
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Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
- 2017
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 44876-
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Tidskriftsartikel (refereegranskat)abstract
- Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively.
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| 6. |
- Laskar, A. H., et al.
(författare)
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Stable Isotopic Characterization of Nor'westers of Southern Assam, NE India
- 2015
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Ingår i: Journal of Climate Change. - : IOS Press. - 2395-7611 .- 2395-7697. ; 1:1-2, s. 75-87
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Tidskriftsartikel (refereegranskat)abstract
- Stable oxygen and hydrogen isotopic compositions (delta O-18 and delta D) of rainwater collected between 2009 and 2011 CE from Hailakandi, southern Assam, north-eastern India have been measured to characterize the extreme rainfall phenomena, delineate moisture sources, determine amount effect and assess the prospect of local proxies for paleoclimate studies. The delta O-18 values range from +0.7 to -13.8 parts per thousand while delta D varies between +12 and -98 parts per thousand. During the pre-monsoon months (March to May), heavy rains and thunderstorms, called nor'westers (Kal Baisakhi in local parlance), occur in some years giving rainfall as much as the monsoons. Strong evaporation and localised convection due to elevated air and sea surface temperature in the region and over the adjacent Bay of Bengal seem to cause nor'wester activity. No amount effect is observed in rain. The d-excess values for nor'wester rains is very different from those of monsoon rain; very low d-excess values (up to -26 parts per thousand) were observed in 2010 CE and attributed to vapour originated from re-evaporation of freshwater, contributed by the lowland water bodies and rivers. The meteoric water line for the nor'wester rains, unlike that for the monsoon season, is significantly different from the Global Meteoric Water Line (GMWL). During the monsoon, the rain becomes progressively more depleted in the heavier isotopes (D and O-18), with the lowest 6 values occurring in Sep-Oct. Oxygen isotope-based paleoclimatic study in this region appears to be confounded by a strong dependence of the rainwater isotopic composition on the source of moisture, uneven distribution of rains during the monsoon and the pre-monsoon seasons and the absence of amount effect.
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