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Association of phys...
Association of physical activity with high-density lipoprotein functionality in a population-based cohort : the REGICOR study
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- Viadas, Raul (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain.
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- Toloba, Andrea (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.
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- Fernandez, Isabel (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.
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- Sayols-Baixeras, Sergi (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Enfermedades Cardiovasc CIBERCV, Madrid, Spain.
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- Hernaez, Alvaro (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway.;Ctr Invest Red Obes & Nutrit CIBEROBN, Madrid, Spain.;Univ Ramon Llull, Fac Ciences Salut Blanquerna, Barcelona, Spain.
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- Schroeder, Helmut (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
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- Degano, Irene R. (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Enfermedades Cardiovasc CIBERCV, Madrid, Spain.;Univ Cent Catalunya, Fac Med, Univ Vic, Barcelona, Spain.
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- Lassale, Camille (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Enfermedades Cardiovasc CIBERCV, Madrid, Spain.
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- Marrugat, Jaume (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Enfermedades Cardiovasc CIBERCV, Madrid, Spain.
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- Elosua, Roberto (författare)
- Inst Hosp Mar Invest Med IMIM, Barcelona, Spain.;Ctr Invest Red Enfermedades Cardiovasc CIBERCV, Madrid, Spain.;Univ Cent Catalunya, Fac Med, Univ Vic, Barcelona, Spain.
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Inst Hosp Mar Invest Med IMIM, Barcelona, Spain;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain. Inst Hosp Mar Invest Med IMIM, Barcelona, Spain. (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Revista Española de Cardiología. - : Elsevier BV. - 0300-8932 .- 1579-2242. ; 76:2, s. 86-93
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction and objectives: To determine the dose-response association between current and past leisure-time physical activity (LTPA), total and at different intensities, and high-density lipoprotein (HDL) functionality parameters.Methods: Study participants (n = 642) were randomly drawn from a large population-based survey. Mean age of the participants was 63.2 years and 51.1% were women. The analysis included data from a baseline and a follow-up visit (median follow-up, 4 years). LTPA was assessed using validated questionnaires at both visits. Two main HDL functions were assessed: cholesterol efflux capacity and HDL antioxidant capacity, at the follow-up visit. Linear regression and linear additive models were used to assess the linear and nonlinear association between LTPA and HDL functionality.Results: Total LTPA at follow-up showed an inverse and linear relationship between 0 and 400 METs x min/d with HDL antioxidant capacity (regression coefficient [beta]:-0.022; 95%CI,-0.030,-0.013), with a plateau above this threshold. The results were similar for moderate (beta:-0.028; 95%CI,-0.049, -0.007) and vigorous (beta:-0.025; 95%CI,-0.043,-0.007), but not for light-intensity LTPA. LTPA at follow-up was not associated with cholesterol efflux capacity. Baseline LTPA was not associated with any of the HDL functionality parameters analyzed.Conclusions: Current moderate and vigorous LTPA showed a nonlinear association with higher HDL antioxidant capacity. Maximal benefit was observed with low-intermediate doses of total LTPA (up to 400 METs x min/d). Our results agree with current recommendations for moderate-vigorous LTPA practice and suggest an association between PA and HDL functionality in the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Nyckelord
- Physical activity
- HDL functionality
- Dose-response
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- art (ämneskategori)
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Viadas, Raul
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Toloba, Andrea
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Fernandez, Isabe ...
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Sayols-Baixeras, ...
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Hernaez, Alvaro
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Schroeder, Helmu ...
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Degano, Irene R.
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Lassale, Camille
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Marrugat, Jaume
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Elosua, Roberto
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- MEDICIN OCH HÄLSOVETENSKAP
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Uppsala universitet