| 1. |
- Province, M. A., et al.
(författare)
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CYP2D6 Genotype and Adjuvant Tamoxifen : Meta-Analysis of Heterogeneous Study Populations
- 2014
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Ingår i: Clinical Pharmacology and Therapeutics. - New York, USA : Nature Publishing Group. - 0009-9236 .- 1532-6535. ; 95:2, s. 216-227
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Tidskriftsartikel (refereegranskat)abstract
- The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1), CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, n = 2,443; P = 0.25) or when no exclusions were applied (criterion 3, n = 4,935; P = 0.38). Although CYP2D6 is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined a priori), prospective studies are necessary to fully establish the value of CYP2D6 genotyping in tamoxifen therapy.
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| 2. |
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| 3. |
- Bergqvist, J, et al.
(författare)
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RASSF1A polymorphism in familial breast cancer
- 2010
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Ingår i: Familial cancer. - : Springer Science and Business Media LLC. - 1573-7292 .- 1389-9600. ; 9:3, s. 263-265
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Latif, K., et al.
(författare)
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Partial virtual channel sharing : A generic methodology to enhance resource management and fault tolerance in networks-on-chip
- 2013
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Ingår i: Journal of electronic testing. - : Springer Science and Business Media LLC. - 0923-8174 .- 1573-0727. ; 29:3, s. 431-452
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Tidskriftsartikel (refereegranskat)abstract
- We present a novel Partial Virtual channel Sharing (PVS) NoC architecture which reduces the impact of faults on performance and also tolerates faults within the routing logic. Without PVS, failure of a component impairs the fault-free connected components, which leads to considerable performance degradation. Improving resource utilization is key in enhancing or sustaining performance with minimal overhead when faults or overload occurs. In the proposed architecture, autonomic virtual-channel buffer sharing is implemented with a novel algorithm that determines the sharing of buffers among a set of ports. The runtime allocation of the buffers depends on incoming load and fault occurrence. In addition, we propose an efficient technique for maintaining the accessibility of a processing element (PE) to the network even if its router is faulty. Our techniques can be used in any NoC topology and for both, 2D and 3D NoCs. The synthesis results for an integrated video conference application demonstrate 22 % reduction in average packet latency compared to state-of-the-art virtual channel (VC) based NoC architecture. Extensive quantitative simulation has been carried out with synthetic benchmarks. Simulation results reveal that the PVS architecture improves the performance significantly in presence of faults, compared to other VC-based NoC architectures.
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| 9. |
- Rahmani, A. M., et al.
(författare)
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Design and management of high-performance, reliable and thermal-aware 3D networks-on-chip
- 2012
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Ingår i: IET Circuits, Devices & Systems. - : Institution of Engineering and Technology (IET). - 1751-858X .- 1751-8598. ; 6:5, s. 308-321
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Tidskriftsartikel (refereegranskat)abstract
- Increasing the number of cores over a 2D plane is not efficient in hyper-core systems due to long interconnects. As a viable alternative over the 2D planar chip, 3D integrated technology offers greater device integration and shorter interlayer interconnects. 3D networks-on-chip (NoC)-bus hybrid mesh architecture, which is a hybrid between packet-switched network and a bus, was proposed to take advantage of the intrinsic attributes of 3D ICs. Even though this architecture was proposed as a feasible one to provide both performance and area benefits, the challenges of combining both media (NoC and bus) to design 3D NoCs have not been addressed. In this study, an efficient 3D NoC architecture is proposed to optimise performance, power consumption and reliability of 3D NoC-bus hybrid mesh system. The mechanism benefits from a congestion-aware and bus failure tolerant routing algorithm called 'AdaptiveZ' for vertical communication. In addition, the authors propose thermal-aware scheduling strategy in order to mitigate temperature by herding most of the switching activity closer to the heatsink. To estimate the efficiency of the proposed architecture, the system has been simulated using uniform, hotspot 10% and negative exponential distribution traffic patterns. In addition, a videoconference encoder has been used as a real application for system analysis. Compared with a typical stacked mesh 3D NoC, our extensive simulations demonstrate significant power, performance and peak temperature improvements.
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| 10. |
- Rahmani, A. M., et al.
(författare)
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Generic Monitoring and Management Infrastructure for 3D NoC-Bus Hybrid Architectures
- 2012
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Ingår i: Networks on Chip (NoCS), 2012 Sixth IEEE/ACM International Symposium on. ; , s. 177-184
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Konferensbidrag (refereegranskat)abstract
- Three-dimensional integrated circuits (3D ICs) achieve enhanced system integration and improved performance at lower cost and reduced area footprint. In order to exploit the intrinsic capability of reducing the wire length in 3D ICs, 3D NoC-Bus Hybrid mesh architecture was proposed which provides performance, power consumption, and area benefits. Besides its various advantages, this architecture has a unique and hitherto previously unexplored way to implement an efficient system-wide monitoring network. In this paper, an integrated low-cost monitoring platform for 3D stacked mesh architectures is proposed which can be efficiently used for various system management purposes such as traffic monitoring, thermal management and fault tolerance. The proposed generic monitoring and management infrastructure called ARB-NET utilizes bus arbiters to exchange the monitoring information directly with each other without using the data network. As a test case, based on the proposed monitoring and management platform, a fully congestion-aware and inter-layer fault tolerant routing algorithm named AdaptiveXYZ is presented taking advantage of viable information generated using bus arbiter network. In addition, we propose a thermal monitoring and management strategy on top of our ARB-NET infrastructure. Compared to recently proposed stacked mesh 3D NoCs, our extensive simulations with synthetic and real benchmarks reveal that our architecture using the AdaptiveXYZ routing can help in achieving significant power and performance improvements while preserving the system reliability with negligible hardware overhead.
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