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Sökning: WFRF:(Latini Roberto) > (2022) > Circulating levels ...

Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure

Vergaro, Giuseppe (författare)
Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
Gentile, Francesco (författare)
Pisa Univ Hosp, Cardiol Div, Pisa, Italy.
Aimo, Alberto (författare)
Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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Januzzi, James L. (författare)
Massachusetts Gen Hosp, Boston, MA 02114 USA.;Baim Inst Clin Res, Boston, MA USA.
Richards, A. Mark (författare)
Univ Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore.
Lam, Carolyn S. P. (författare)
Natl Heart Ctr Singapore, Singapore, Singapore.;Duke Natl Univ Singapore, Singapore, Singapore.
Boer, Rudolf A. (författare)
Univ Med Ctr Groningen, Groningen, Netherlands.
Meems, Laura M. G. (författare)
Univ Med Ctr Groningen, Groningen, Netherlands.
Latini, Roberto (författare)
Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy.
Staszewsky, Lidia (författare)
Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy.
Anand, Inder S. (författare)
Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.;VA Med Ctr, Minneapolis, MN USA.
Cohn, Jay N. (författare)
Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.
Ueland, Thor (författare)
Oslo Univ Hosp, Oslo, Norway.;Oslo Univ Hosp, Rikshosp, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.;Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway.
Gullestad, Lars (författare)
Univ Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway.;Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway.
Aukrust, Pal (författare)
Oslo Univ Hosp, Rikshosp, Oslo, Norway.
Rocca, Hans-Peter Brunner-La (författare)
Maastricht Univ, Med Ctr, Maastricht, Netherlands.
Bayes-Genis, Antoni (författare)
Hosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain.
Lupon, Josep (författare)
Hosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain.
Yoshihisa, Akiomi (författare)
Fukushima Med Univ, Dept Internal Med 1, Fukushima, Japan.
Takeishi, Yasuchika (författare)
Fukushima Med Univ, Dept Internal Med 1, Fukushima, Japan.
Egstrup, Michael (författare)
Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
Gustafsson, Ida (författare)
Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
Gaggin, Hanna K. (författare)
Massachusetts Gen Hosp, Heart Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.
Eggers, Kai M., 1962- (författare)
Uppsala universitet,Kardiologi
Huber, Kurt (författare)
Wilhelminenspital Stadt Wien, Vienna, Austria.;Sigmund Freud Univ, Med Sch, Vienna, Austria.
Gamble, Greg D. (författare)
Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand.
Ling, Lieng H. (författare)
Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore.
Leong, Kui Toh Gerard (författare)
Changi Gen Hosp, Singapore, Singapore.
Yeo, Poh Shuah Daniel (författare)
Tan Tock Seng Hosp, Singapore, Singapore.
Ong, Hean Yee (författare)
Khoo Teck Puat Hosp, Singapore, Singapore.
Jaufeerally, Fazlur (författare)
Singapore Gen Hosp, Singapore, Singapore.
Ng, Tze P. (författare)
Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore.
Troughton, Richard (författare)
Univ Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore.
Doughty, Robert N. (författare)
Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand.
Devlin, Gerry (författare)
Gisborne Hosp, Gisborne, New Zealand.
Lund, Mayanna (författare)
Middlemore Hosp, Auckland, New Zealand.
Giannoni, Alberto (författare)
Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
Passino, Claudio (författare)
Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
Emdin, Michele (författare)
Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.
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Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. Pisa Univ Hosp, Cardiol Div, Pisa, Italy. (creator_code:org_t)
2022-05-05
2022
Engelska.
Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 9:4, s. 2084-2095
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women and men with chronic heart failure (HF). Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium with sST2, hs-cTnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1 year cardiovascular death and HF hospitalization. The secondary endpoints were 5 year cardiovascular and all-cause death. The cohort included 4540 patients (age 67 +/- 12 years, left ventricular ejection fraction 33 +/- 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/mL, P < 0.001) and hs-cTnT level (15 vs. 20 ng/L, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/L, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/mL) and hs-cTnT (22 vs. 25 ng/L), while NT-proBNP cut-off was higher in women (2339 ng/L vs. 2145 ng/L). The use of sex-specific cut-offs improved risk prediction compared with the use of previously standardized prognostic cut-offs and allowed to reclassify the risk of many patients, to a greater extent in women than men, and for hs-cTnT than sST2 or NT-proBNP. Specifically, up to 18% men and up to 57% women were reclassified, by using the sex-specific cut-off of hs-cTnT for the endpoint of 5 year cardiovascular death. Conclusions In patients with chronic HF, concentrations of sST2 and hs-cTnT, but not of NT-proBNP, are lower in women. Lower sST2 and hs-cTnT and higher NT-proBNP cut-offs for risk stratification could be used in women.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Chronic heart failure
Sex
Women
Prognosis
sST2
High-sensitivity troponin T
NT-proBNP

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