Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease.

• Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers Aβ42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Alzheimer Disease

cerebrospinal fluid

Amyloid beta-Peptides

cerebrospinal fluid

Complement C3

cerebrospinal fluid

Complement C4

cerebrospinal fluid

Disease Progression

Female

Humans

Male

Middle Aged

Mild Cognitive Impairment

cerebrospinal fluid

Peptide Fragments

cerebrospinal fluid

Receptors

Complement

metabolism

tau Proteins

cerebrospinal fluid

Alzheimer's disease

Biomarkers

C3

C4

CR1

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)