| 1. |
- Heng, Kevin, et al.
(författare)
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Evolution of the Reverse Shock Emission from SNR 1987A
- 2006
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 644, s. 959-970
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Tidskriftsartikel (refereegranskat)abstract
- We present new (2004 July) G750L and G140L Space Telescope Imaging Spectrograph (STIS) data of the Hα and Lyα emission from supernova remnant (SNR) 1987A. With the aid of earlier data, from 1997 October to 2002 October, we track the local evolution of Lyα emission and both the local and global evolution of Hα emission. The most recent observations allow us to directly compare the Hα and Lyα emission from the same slit position and at the same epoch. Consequently, we find clear evidence that, unlike Hα, Lyα is reflected from the debris by resonant scattering. In addition to emission that we can clearly attribute to the surface of the reverse shock, we also measure comparable emission, in both Hα and Lyα, that appears to emerge from supernova debris interior to the surface. New observations taken through slits positioned slightly eastward and westward of a central slit show a departure from cylindrical symmetry in the Hα surface emission. Using a combination of old and new observations, we construct a light curve of the total Hα flux, F, from the reverse shock, which has increased by a factor of ~4 over about 8 yr. However, due to large systematic uncertainties, we are unable to discern between the two limiting behaviors of the flux: F~t (self-similar expansion) and F~t5 (halting of the reverse shock). Such a determination is important for constraining the rate of hydrogen atoms crossing the shock, which is relevant to the question of whether the reverse shock emission will vanish in <~7 yr. Future deep, low- or moderate-resolution spectra are essential for accomplishing this task.
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| 2. |
- Aggett, Peter J, et al.
(författare)
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Feeding preterm infants after hospital discharge : a commentary by the ESPGHAN Committee on Nutrition.
- 2006
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Ingår i: Journal of pediatric gastroenterology and nutrition. - : Ovid Technologies (Wolters Kluwer Health). - 1536-4801 .- 0277-2116. ; 42:5, s. 596-603
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Tidskriftsartikel (refereegranskat)abstract
- Survival of small premature infants has markedly improved during the last few decades. These infants are discharged from hospital care with body weight below the usual birth weight of healthy term infants. Early nutrition support of preterm infants influences long-term health outcomes. Therefore, the ESPGHAN Committee on Nutrition has reviewed available evidence on feeding preterm infants after hospital discharge. Close monitoring of growth during hospital stay and after discharge is recommended to enable the provision of adequate nutrition support. Measurements of length and head circumference, in addition to weight, must be used to identify those preterm infants with poor growth that may need additional nutrition support. Infants with an appropriate weight for postconceptional age at discharge should be breast-fed when possible. When formula-fed, such infants should be fed regular infant formula with provision of long-chain polyunsaturated fatty acids. Infants discharged with a subnormal weight for postconceptional age are at increased risk of long-term growth failure, and the human milk they consume should be supplemented, for example, with a human milk fortifier to provide an adequate nutrient supply. If formula-fed, such infants should receive special postdischarge formula with high contents of protein, minerals and trace elements as well as an long-chain polyunsaturated fatty acid supply, at least until a postconceptional age of 40 weeks, but possibly until about 52 weeks postconceptional age. Continued growth monitoring is required to adapt feeding choices to the needs of individual infants and to avoid underfeeding or overfeeding
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| 3. |
- Danelid, Hans, et al.
(författare)
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Kartläggning av högskolans elektroniska publicering och rekommendationer för nationell samverkan : Återrapportering till SUHF:s Forum för bibliotekschefer
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Resultatet av arbetsgruppens genomförda kartläggning av e-publicering visar att den stora utmaningen för de flesta av SUHF:s medlemmar som idag driver system för e-publicering är att marknadsföra och förankra detta arbete. Det finns svårigheter att nå ut till anställda på det sätt som krävs för att få igång fungerande arbetsflöden och ökad digital publicering. Därför är det nu viktigt att fortsätta utvecklingen med att skapa en bredare förankring vid universitet och högskolor. Kartläggningen visar vidare att intresset för nationell samordning av elektro-nisk publicering är stort hos de lokalt ansvariga för publiceringsfrågor. Här har SUHF en vik-tig funktion att fylla för att bistå med förankring och samordning.Arbetsgruppen för Högskolans elektroniska publicering rekommenderar följande fortsatta åtgärder för nationell samverkan via SUHF/Forum för bibliotekschefer:• SUHF tar ansvar för en permanent övergripande och nationell samverkan kring hög-skolans elektroniska publicering.• SUHF formulerar riktlinjer till lärosätenas ledningar för hur elektronisk publicering, publiceringsredovisning och Open Access kan införlivas i lärosätenas verksamhet.• SUHF bör försöka hitta gemensamma finansieringsformer för funktioner där samord-ning är angelägen.
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| 4. |
- Ding, Li, et al.
(författare)
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Somatic mutations affect key pathways in lung adenocarcinoma
- 2008
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 455:7216, s. 1069-1075
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Tidskriftsartikel (refereegranskat)abstract
- Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
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| 5. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 6. |
- Harrington, Robert A., et al.
(författare)
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial : study design and rationale
- 2009
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 158:3, s. 327-334
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Tidskriftsartikel (refereegranskat)abstract
- Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies.
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| 7. |
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| 8. |
- Lawrence, David, 1967-, et al.
(författare)
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A Swedish Journal Publication Service
- 2007
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Ingår i: Högskolor och samhälle i samverkan (HSS).
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In 2002, Linköping University Electronic Press began development of a journal article reviewing support system (JARSS) as a tool for Editors of electronic journals. The system-s database contains submitted articles, abstracts and other secondary information, reviews, and e-mail communication for the purpose of submission, reviewing and final acceptance. The interface maintains a log of all events pertaining to the article and the associated status changes. The successive status options of an article (received, under review, conditional accept, etc.) correspond to the editorial workflow. JARRS has been used since its inception to run the Artificial Intelligence Journal (AIJ), an Elsevier publication. In essence a service is offered to take care of the technical aspects of journal publication, allowing editors more time to solicit papers of high quality.
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| 9. |
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| 10. |
- Mohammad, Rezwan, 1975-
(författare)
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Some aspects of the Atlantic ocean circulation
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis deals with the ocean circulation from two viewpoints: Pro primo, the dependence of the global thermohaline ocean circulation (THC) on the parameterization of the small-scale vertical mixing processes in the interior of the ocean, and, pro secundo, the dynamics of the circulation in the Nordic Seas. The THC is found be crucially dependent on the parameterization of the small-scale vertical mixing, two types of which have been compared: The commonly used constant diffusivity and a, physically more plausible, stability-dependent parameterization. For constant diffusivity the circulation weakens when the equator-to-pole surface density difference is decreased, consonant with commonly held prejudices. However, for stability-dependent diffusivity the circulation is enhanced. This conclusion has been reached using two investigative techniques, viz. a scale analysis as well as a numerical zonally-averaged and equatorially symmetric THC model. However, if asymmetric flows are considered, the dynamics become more complex to interpret. It has, nevertheless, been concluded that when the degree of asymmetry of the surface-density distribution is taken to be fixed, the response of the circulation to changes of the surface-density distribution corresponds to that from the symmetric investigation.The studies of the Nordic Seas are mainly based on satellite-altimetric data providing Sea-Level Anomalies (SLAs). These are utilized to estimate the seasonal cycle as well as the inter-annual variability of the depth-integrated flows. The seasonal cycle is examined using the winter-to-summer difference of the barotropic flow, with focus on the entire region as well as on two sections extending from a common point in the central Norwegian Sea to Svinøy on the Norwegian coast and to the Faroe Islands, respectively. The total barotropic transport is estimated to be around 10 Sv larger during winter than in summer, of which 8 Sv are associated with the barotropic re-circulation gyre in the interior of the Norwegian Sea, the remainder being linked to the Atlantic inflow across the Iceland-Scotland Ridge. The inter-annual variability of the circulation in the Nordic Seas is investigated on the basis of a theoretical analysis permitting independent calculation of the barotropic flow along closed isobaths using SLA data as well as wind data. The barotropic flow based on SLA data is found to co-vary with the flow estimated using wind data.
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