| 1. |
- Abdallah, Jalal, et al.
(författare)
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Study of energy response and resolution of the ATLAS Tile Calorimeter to hadrons of energies from 16 to 30 GeV
- 2021
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 81:6
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Tidskriftsartikel (refereegranskat)abstract
- Three spare modules of the ATLAS Tile Calorimeter were exposed to test beams from the Super Proton Synchrotron accelerator at CERN in 2017. The detector’s measurements of the energy response and resolution to positive pions and kaons, and protons with energies ranging from 16 to 30 GeV are reported. The results have uncertainties of a few percent. They were compared to the predictions of the Geant4-based simulation program used in ATLAS to estimate the response of the detector to proton-proton events at the Large Hadron Collider. The determinations obtained using experimental and simulated data agree within the uncertainties.
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| 2. |
- Aartsen, M. G., et al.
(författare)
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Development of an analysis to probe the neutrino mass ordering with atmospheric neutrinos using three years of IceCube DeepCore data IceCube Collaboration
- 2020
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Ingår i: European Physical Journal C. - : SPRINGER. - 1434-6044 .- 1434-6052. ; 80:1
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Tidskriftsartikel (refereegranskat)abstract
- The Neutrino Mass Ordering (NMO) remains one of the outstanding questions in the field of neutrino physics. One strategy to measure the NMO is to observe matter effects in the oscillation pattern of atmospheric neutrinos above similar to 1GeV, as proposed for several next-generation neutrino experiments. Moreover, the existing IceCube DeepCore detector can already explore this type of measurement. We present the development and application of two independent analyses to search for the signature of the NMO with three years of DeepCore data. These analyses include a full treatment of systematic uncertainties and a statistically-rigorous method to determine the significance for the NMO from a fit to the data. Both analyses show that the dataset is fully compatible with both mass orderings. For the more sensitive analysis, we observe a preference for normal ordering with a p-value of pIO=15.3% and CLs=53.3% for the inverted ordering hypothesis, while the experimental results from both analyses are consistent within their uncertainties. Since the result is independent of the value of delta CP and obtained from energies E nu greater than or similar to 5GeV, it is complementary to recent results from long-baseline experiments. These analyses set the groundwork for the future of this measurement with more capable detectors, such as the IceCube Upgrade and the proposed PINGU detector.
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| 3. |
- Aartsen, M. G., et al.
(författare)
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Neutrinos below 100 TeV from the southern sky employing refined veto techniques to IceCube data
- 2020
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Ingår i: Astroparticle physics. - : ELSEVIER. - 0927-6505 .- 1873-2852. ; 116
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Tidskriftsartikel (refereegranskat)abstract
- Many Galactic sources of gamma rays, such as supernova remnants, are expected to produce neutrinos with a typical energy cutoff well below 100 TeV. For the IceCube Neutrino Observatory located at the South Pole, the southern sky, containing the inner part of the Galactic plane and the Galactic Center, is a particularly challenging region at these energies, because of the large background of atmospheric muons. In this paper, we present recent advancements in data selection strategies for track-like muon neutrino events with energies below 100 TeV from the southern sky. The strategies utilize the outer detector regions as veto and features of the signal pattern to reduce the background of atmospheric muons to a level which, for the first time, allows IceCube searching for point-like sources of neutrinos in the southern sky at energies between 100 GeV and several TeV in the muon neutrino charged current channel. No significant clustering of neutrinos above background expectation was observed in four years of data recorded with the completed IceCube detector. Upper limits on the neutrino flux for a number of spectral hypotheses are reported for a list of astrophysical objects in the southern hemisphere.
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| 4. |
- Doolittle, Joseph, et al.
(författare)
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Partition and Cohen-Macaulay extenders
- 2022
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Ingår i: European journal of combinatorics (Print). - : Elsevier BV. - 0195-6698 .- 1095-9971. ; 102
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Tidskriftsartikel (refereegranskat)abstract
- If a pure simplicial complex is partitionable, then its h-vector has a combinatorial interpretation in terms of any partitioning of the complex. Given a non-partitionable complex increment , we construct a complex Gamma superset of increment of the same dimension such that both Gamma and the relative complex (Gamma , increment ) are partitionable. This allows us to rewrite the h-vector of any pure simplicial complex as the difference of two h-vectors of partitionable complexes, giving an analogous interpretation of the h-vector of a non-partitionable complex. By contrast, for a given complex increment it is not always possible to find a complex Gamma such that both Gamma and (Gamma , increment ) are Cohen- Macaulay. We characterize when this is possible, and we show that the construction of such a Gamma in this case is remarkably straightforward. We end with a note on a similar notion for shellability and a connection to Simon's conjecture on extendable shellability for uniform matroids.
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| 5. |
- Gonzalez-Ericsson, Paula, et al.
(författare)
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The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers into breast cancer clinical trials and daily practice
- 2020
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Ingår i: Journal of Pathology. - : Wiley. - 1096-9896 .- 0022-3417. ; 250:5, s. 667-684
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Forskningsöversikt (refereegranskat)abstract
- Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD‐L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab‐paclitaxel. However, concerns regarding variability between immunohistochemical PD‐L1 assay performance and inter‐reader reproducibility have been raised. High tumor‐infiltrating lymphocytes (TILs) have also been associated with response to PD‐1/PD‐L1 inhibitors in patients with breast cancer (BC). TILs can be easily assessed on hematoxylin and eosin–stained slides and have shown reliable inter‐reader reproducibility. As an established prognostic factor in early stage TNBC, TILs are soon anticipated to be reported in daily practice in many pathology laboratories worldwide. Because TILs and PD‐L1 are parts of an immunological spectrum in BC, we propose the systematic implementation of combined PD‐L1 and TIL analyses as a more comprehensive immuno‐oncological biomarker for patient selection for PD‐1/PD‐L1 inhibition‐based therapy in patients with BC. Although practical and regulatory considerations differ by jurisdiction, the pathology community has the responsibility to patients to implement assays that lead to optimal patient selection. We propose herewith a risk‐management framework that may help mitigate the risks of suboptimal patient selection for immuno‐therapeutic approaches in clinical trials and daily practice based on combined TILs/PD‐L1 assessment in BC.
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| 6. |
- Hatos, Andras, et al.
(författare)
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DisProt : intrinsic protein disorder annotation in 2020
- 2020
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 48:D1, s. D269-D276
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Tidskriftsartikel (refereegranskat)abstract
- The Database of Protein Disorder (DisProt, URL:https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.
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| 7. |
- Hodosi, Georg, et al.
(författare)
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Factors for Successful IT Outsourcing Relationships in Large Companies in Sweden : A Service Buyer’s Perspective
- 2020
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Ingår i: Information Systems. - Cham : Springer. - 9783030443214 - 9783030443221 ; , s. 486-497
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Konferensbidrag (refereegranskat)abstract
- Relationship management in IT Outsourcing (ITO) is widely accepted as a prerequisite for a successful ITO. However, there is still a need for understanding the important factors that contribute to a successful ITO relationship in large companies in Sweden. Therefore, this study wants to address this knowledge gap. The studied companies are the largest ones regarding turnover in Sweden and are present in the “Large Cap” segment at Nasdaq Stockholm Exchange. The results of this research are compared with a previous study done in 2012 in large companies in Sweden. The findings show that the most important factors (from a buyer’s perspective) for a successful ITO relationship are communication; conflict and conflict resolution; trust; commitment; cooperation; and internal competence. The identified relational factors in this study contribute to ITO research and can help ITO decision-makers in large companies to have successful ITO relationships and improve their ITO.
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| 8. |
- Hopkins, Sam, et al.
(författare)
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On the q-enumeration of barely set-valued tableaux and plane partitions
- 2023
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Ingår i: European journal of combinatorics (Print). - : Elsevier BV. - 0195-6698 .- 1095-9971. ; 113
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Tidskriftsartikel (refereegranskat)abstract
- Barely set-valued tableaux are a variant of Young tableaux in which one box contains two numbers as its entry. It has recently been discovered that there are product formulas enumerating certain classes of barely set-valued tableaux. We give some q-analogs of these product formulas by introducing a version of major index for these tableaux. We also give product formulas and q-analogs for barely set-valued plane partitions. Many of the results are stated in the generality of P-partitions that then specialize to particularly nice formulas for rectangles and minuscule posets. The proofs use several probability distributions on the set of order ideals of a poset, depending on the real parameter q>0, which we think could be of independent interest.
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| 9. |
- Lazar, Alexander
(författare)
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Ferrers graphs, D-permutations, and surjective staircases
- 2023
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Ingår i: The Ramanujan journal. - : Springer Nature. - 1382-4090 .- 1572-9303. ; 60:2, s. 391-426
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a new family of hyperplane arrangements inspired by the homogenized Linial arrangement (which was recently introduced by Hetyei), and show that the intersection lattices of these arrangements are isomorphic to the bond lattices of Ferrers graphs. Using recent work of Lazar and Wachs we are able to give combinatorial interpretations of the characteristic polynomials of these arrangements in terms of permutation enumeration. For certain infinite families of these hyperplane arrangements, we are able to give generating function formulas for their characteristic polynomials. To do so, we develop a generalization of Dumont’s surjective staircases, and introduce a polynomial which enumerates these generalized surjective staircases according to several statistics. We prove a recurrence for these polynomials and show that in certain special cases this recurrence can be solved explicitly to yield a generating function. We also prove refined versions of several of these results using the theory of complex hyperplane arrangements.
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| 10. |
- Lazar, Alexander, et al.
(författare)
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The homogenized Linial arrangement and Genocchi numbers
- 2022
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Ingår i: Combinatorial Theory. - : California Digital Library (CDL). - 2766-1334. ; 2:1
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Tidskriftsartikel (refereegranskat)abstract
- We study the intersection lattice of a hyperplane arrangement recently introduced by Hetyei who showed that the number of regions of the arrangement is a median Genocchi number. Using a different method, we refine Hetyei’s result by providing a combinatorial interpretation of the coefficients of the characteristic polynomial of the intersection lattice of this arrangement. The Genocchi numbers count a class of permutations known as Dumont permutations and the median Genocchi numbers count the derangements in this class. We show that the signless coefficients of the characteristic polynomial count Dumont-like permutations with a given number of cycles. This enables us to derive formulas for the generating function of the characteristic polynomial, which reduce to known formulas for the generating functions of the Genocchi numbers and the median Genocchi numbers. As a byproduct of our work, we obtain new models for the Genocchi and median Genocchi numbers.
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