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Träfflista för sökning "WFRF:(Lazzaro A.) srt2:(2005-2009)"

Sökning: WFRF:(Lazzaro A.) > (2005-2009)

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1.
  • Clark, Andrew G., et al. (författare)
  • Evolution of genes and genomes on the Drosophila phylogeny
  • 2007
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
  • Tidskriftsartikel (refereegranskat)abstract
    • Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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2.
  • di Tommaso, P., et al. (författare)
  • The simulation of anomalies in the functional testing of the ERTMS/ETCS trackside system
  • 2005
  • Ingår i: HASE 2005 : Ninth IEEE International Symposium on High Assurance Systems Engineering. - Heidelberg : Springer. - 0769523773 - 9780769523774 ; , s. 131-139
  • Konferensbidrag (refereegranskat)abstract
    • ERTMS/ETCS is going to become the reference standard for modern railway signalling. To develop a safe and reliable Automatic Train Protection System (ATPS) based on ERTMS/ETCS, a detailed functional testing phase is needed, meeting the requirements of international railway safety standards. In this paper we deal with the functional validation of the trackside part of an ERTMS/ETCS compliant system. An extensive set of functional tests have been specified in order to thoroughly verify the system, using an innovative approach based on influence variables and state diagrams. However, such a detailed test specification requires a great amount of time and resources to be entirely executed in the real environment. Moreover, several tests need to generate abnormal safety-critical conditions that are unfeasible on the field. In this paper we describe how we overcame such problems using a specific simulation environment capable to quickly and automatically execute anomaly tests in normal as well as in degraded operating conditions.
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3.
  • Sackton, Timothy B, et al. (författare)
  • Dynamic evolution of the innate immune system in Drosophila.
  • 2007
  • Ingår i: Nat Genet. - 1061-4036. ; 39:12, s. 1461-8
  • Tidskriftsartikel (refereegranskat)abstract
    • The availability of complete genome sequence from 12 Drosophila species presents the opportunity to examine how natural selection has affected patterns of gene family evolution and sequence divergence among different components of the innate immune system. We have identified orthologs and paralogs of 245 Drosophila melanogaster immune-related genes in these recently sequenced genomes. Genes encoding effector proteins, and to a lesser extent genes encoding recognition proteins, are much more likely to vary in copy number across species than genes encoding signaling proteins. Furthermore, we can trace the apparent recent origination of several evolutionarily novel immune-related genes and gene families. Using codon-based likelihood methods, we show that immune-system genes, and especially those encoding recognition proteins, evolve under positive darwinian selection. Positively selected sites within recognition proteins cluster in domains involved in recognition of microorganisms, suggesting that molecular interactions between hosts and pathogens may drive adaptive evolution in the Drosophila immune system.
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  • Resultat 1-3 av 3

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