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| 2. |
- Hale, G, et al.
(författare)
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Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
- 2004
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 104:4, s. 948-955
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Tidskriftsartikel (refereegranskat)abstract
- Alemtuzumab is a humanized anti-CD52 antibody licensed for refractory B-cell chronic lymphocytic leukemia (B-CLL), when given intravenously at 30 mg thrice weekly. However, the intravenous route is associated with infusion-related reactions and is inconvenient. We measured blood concentrations in 30 relapsed patients treated with intravenous alemtuzumab and in 20 patients from a previously untreated group who received similar doses subcutaneously. Highest trough samples in the intravenous group were less than 0.5 μg/mL to 18.3 μg/mL (mean 5.4 μg/mL). The cumulative dose required to reach 1.0 μg/mL was 13 mg to 316 mg (mean 90 mg). Higher blood concentrations correlated with the achievement of better clinical responses and minimal residual disease. The highest measured concentrations in the subcutaneous group were similar (0.6 μg/mL to 24.8 μg/mL, mean 5.4 μg/mL). However, the cumulative dose to reach 1.0 μg/mL was higher: 146 mg to 1106 mg (mean 551 mg). No antiglobulin responses were detected in 30 patients given intravenous alemtuzumab whereas 2 of 32 patients given subcutaneous alemtuzumab made substantial anti-idiotype responses. Thus, subcutaneous alemtuzumab achieved concentrations similar to those for intravenous alemtuzumab, although with slightly higher cumulative doses. Subcutaneous alemtuzumab is more convenient and better tolerated but may be associated with some patients forming anti–alemtuzumab antibodies, particularly those patients who were previously untreated.
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| 3. |
- Kahn, Joel S., et al.
(författare)
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Anthropology and Modernity1/Comments/Reply
- 2001
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Ingår i: Current Anthropology. ; 42:5
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Tidskriftsartikel (refereegranskat)abstract
- Â Against those who have taken anthropologists to task for flirting with the "meta-narratives" of modernity, this article argues that it is incumbent on them to engage with both modernity and modernist narratives far more directly and explicitly than in the past. This holds even, or especially, for those who, in positing a notion of multiple modernities, have managed to hold modernist narrative at arm’s length, neglecting the potential fruitfulness of juxtaposing Western and non-Western experiences of what Habermas has called the project of modernity. The encounter between anthropology and modernity is generated on the one hand by changes in the lives of the subjects of ethnographic research, but the fact of these changes raises more searching questions about whether ethnographers ever studied genuinely premodern peoples and cultures. The reflexive imperative, moreover, confirms the need to recognize anthropology’s own modernist origins. Finally it is argued that it is critical modernist theory in the Hegel-Marx-Weber tradition that is the most pertinent to the ethnographic encounter and that the exercise of bringing together critical theory and ethnographic knowledge, while conflictual, produces fruitful results for both sides. [PUBLICATION ABSTRACT]
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| 4. |
- Scherer, SW, et al.
(författare)
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Human chromosome 7: DNA sequence and biology
- 2003
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
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Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
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