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- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 2. |
- Lee, Francis, 1974-
(författare)
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Letters & Bytes : Sociotechnical Studies of Distance Education
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation studies the social aspects of technology in distance education trough the lens of history – in the form of correspondence education – and a possible future – in the form of a project of technical standardization, Learning Objects. The studied cases form a reflexive tool that allows the present of distance education to be seen in perspective.In the case of correspondence education, the dissertation shows how the mundane technologies of correspondence letters, grading-forms, answer-templates and self-tests create a specific mode of organizing distance education that bridges the rift between the two major trends in educational modernity: massification and individualization. This attempt brought with it specific consequences for the organization of correspondence education: educators tried to devise methods for individual instruction, but at the same time they tried to industrialize the production through the mass-production of instructional letters. Hence, particular identities and modes of organizing education and arose. The correspondence education cases are studied through conference proceedings and archive material.The contemporary cases study the heterogeneous construction of technical standards for the exchange of distance education material between computer systems, so-called Learning Objects. Through these cases, the dissertation shows that Learning Objects are closely tied to a dream of economies of scale and a market for distance education material with particular epistemic and technical consequences. Furthermore, the cases show how the attempt to create economies of scale results in an object oriented and modular way of reusing educational material; and how this modularization leads to an objectified mode of handling knowledge with emphasis on atomization of knowledge, as well as the protection of intellectual property rights through DRM-Technology. The contemporary cases are studied through technical standards and text-analysis.
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| 5. |
- Peacock, Christopher S, et al.
(författare)
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Comparative genomic analysis of three Leishmania species that cause diverse human disease.
- 2007
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:7, s. 839-847
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Tidskriftsartikel (refereegranskat)abstract
- Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
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