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Genomewide analysis...
Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast
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- Wiren, Marianna (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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- Silverstein, Rebecca A (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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- Sinha, Indranil (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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- Walfridsson, Julian (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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- Lee, Hang-mao (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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- Laurenson, P (author)
- University of California, San Diego, USA
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- Pillus, L (author)
- University of California, San Diego, USA
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- Robyr, D (author)
- University of California, Los Angeles, USA
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- Grunstein, M (author)
- University of California, Los Angeles, USA
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- Ekwall, Karl (author)
- Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institutet
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(creator_code:org_t)
- 2005-08-04
- 2005
- English.
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In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 24:16, s. 2906-2918
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Abstract
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- We have conducted a genomewide investigation into the enzymatic specificity, expression profiles, and binding locations of four histone deacetylases (HDACs), representing the three different phylogenetic classes in fission yeast ( Schizosaccharomyces pombe). By directly comparing nucleosome density, histone acetylation patterns and HDAC binding in both intergenic and coding regions with gene expression profiles, we found that Sir2 ( class III) and Hos2 ( class I) have a role in preventing histone loss; Clr6 ( class I) is the principal enzyme in promoter-localized repression. Hos2 has an unexpected role in promoting high expression of growth-related genes by deacetylating H4K16Ac in their open reading frames. Clr3 ( class II) acts cooperatively with Sir2 throughout the genome, including the silent regions: rDNA, centromeres, mat2/3 and telomeres. The most significant acetylation sites are H3K14Ac for Clr3 and H3K9Ac for Sir2 at their genomic targets. Clr3 also affects subtelomeric regions which contain clustered stress- and meiosis-induced genes. Thus, this combined genomic approach has uncovered different roles for fission yeast HDACs at the silent regions in repression and activation of gene expression.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Wiren, Marianna
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Silverstein, Reb ...
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Sinha, Indranil
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Walfridsson, Jul ...
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Lee, Hang-mao
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Laurenson, P
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show more...
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Pillus, L
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Robyr, D
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Grunstein, M
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Ekwall, Karl
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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EMBO Journal
- By the university
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Södertörn University
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Karolinska Institutet