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Träfflista för sökning "WFRF:(Lehner B) srt2:(2010-2014)"

Sökning: WFRF:(Lehner B) > (2010-2014)

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  • Malbrunot, C., et al. (författare)
  • Spectroscopy apparatus for the measurement of the hyperfine structure of antihydrogen
  • 2014
  • Ingår i: Hyperfine Interactions. - : Springer Science and Business Media LLC. - 0304-3843 .- 1572-9540. ; 228:1-3, s. 61-66
  • Tidskriftsartikel (refereegranskat)abstract
    • The ASACUSA CUSP collaboration at the Antiproton Decelerator (AD) of CERN is planning to measure the ground-state hyperfine splitting of antihydrogen (H̄) using an atomic spectroscopy beamline. We describe here the latest developments on the spectroscopy apparatus developed to be coupled to the H̄ production setup (CUSP).
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3.
  • Smoller, JW, et al. (författare)
  • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
  • 2013
  • Ingår i: Lancet. - 1474-547X. ; 381:9875, s. 1371-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.
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5.
  • Fuhrmann, Jakob, et al. (författare)
  • Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria
  • 2013
  • Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 3:6, s. 1832-1839
  • Tidskriftsartikel (refereegranskat)abstract
    • Many cellular pathways are regulated by the competing activity of protein kinases and phosphatases. The recent identification of arginine phosphorylation as a protein modification in bacteria prompted us to analyze the molecular basis of targeting phosphoarginine. In this work, we characterize an annotated tyrosine phosphatase, YwlE, that counteracts the protein arginine kinase McsB. Strikingly, structural studies of YwlE reaction intermediates provide a direct view on a captured arginine residue. Together with biochemical data, the crystal structures depict the evolution of a highly specific phospho-arginine phosphatase, with the use of a size-and-polarity filter for distinguishing phosphorylated arginine from other phosphorylated side chains. To confirm the proposed mechanism, we performed bioinformatic searches for phosphatases, employing a similar selectivity filter, and identified a protein in Drosophila melanogaster exhibiting robust arginine phosphatase activity. In sum, our findings uncover the molecular framework for specific targeting of phospho-arginine and suggest that protein arginine (de) phosphorylation may be relevant in eukaryotes.
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  • Resultat 1-5 av 5

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