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- Adhikari, I, et al.
(författare)
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Association of Chlamydia trachomatis infection with cervical atypia in adolescent women with short-term or long-term use of oral contraceptives: a longitudinal study in HPV vaccinated women
- 2022
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:6, s. e056824-
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Tidskriftsartikel (refereegranskat)abstract
- We assessed the relationship between Chlamydia trachomatis infection, duration of oral contraceptive (OC) use and cervical atypia among young adult Finnish women.DesignA longitudinal study.Setting and participantsWomen who were included in this study participated in a community-randomised trial on the effectiveness of human papillomavirus (HPV) vaccination and C. trachomatis screening at ages 18.5 and 22 years in Finland. They completed questionnaires on both visits about sexual behaviours. The cytology test results at age 18.5 and 22 years were also available for those women. The total number of participants in this study at 18.5 years of age were 11 701 and at 22 years of age were 6618.Main outcome measureORs with 95% CIs using univariable and multivariable logistic regression were used to assess the association between C. trachomatis infection, duration of OC and squamous intraepithelial lesions (SIL).ResultsThere were 940 cytological SIL cases at the first screening visit and 129 cytological SIL cases at the second screening visit. Among the 22 years old, more than fourfold adjusted risk of SIL was associated with C. trachomatis positivity. The HPV16/18, condom use, smoking and number of sexual partners adjusted joint effect of prolonged OC use and C. trachomatis was significantly increased (OR 4.7, 95% CI 1.7 to 12.8) in the 22-year-old women. This observed joint effect was 1.6 times higher than expected on a multiplicative scale. On additive scale, the observed relative excess risk from interaction was 1.8.ConclusionThe risk of SIL in HPV vaccinated women is significantly increased if they are C. trachomatis positive and have used OC for 5 or more years. The biological basis may be lack of condom facilitated protection against sexually transmitted diseases.Trial registration numberNCT00534638.
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- Lehtinen, J. J., et al.
(författare)
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Topological changes in the magnetic field of LQ Hya during an activity minimum
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 660
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Previous studies have related surface temperature maps, obtained with the Doppler imaging (DI) technique, of LQ Hya with long-term photometry. Here, we compare surface magnetic field maps, obtained with the Zeeman Doppler imaging (ZDI) technique, with contemporaneous photometry, with the aim of quantifying the star's magnetic cycle characteristics. Methods. We inverted Stokes IV spectropolarimetry, obtained with the HARPSpol and ESPaDOnS instruments, into magnetic field and surface brightness maps using a tomographic inversion code that models high signal-to-noise ratio mean line profiles produced by the least squares deconvolution (LSD) technique. The maps were compared against long-term ground-based photometry acquired with the T3 0.40 m Automatic Photoelectric Telescope (APT) at Fairborn Observatory, which offers a proxy for the spot cycle of the star, as well as with chromospheric Ca II H&K activity derived from the observed spectra. Results. The magnetic field and surface brightness maps reveal similar patterns relative to previous DI and ZDI studies: nonaxisymmetric polar magnetic field structure, void of fields at mid-latitudes, and a complex structure in the equatorial regions. There is a weak but clear tendency of the polar structures to be linked with a strong radial field and the equatorial ones with the azimuthal field. We find a polarity reversal in the radial field between 2016 and 2017 that is coincident with a spot minimum seen in the long-term photometry, although the precise relation of chromospheric activity to the spot activity remains complex and unclear. The inverted field strengths cannot be easily related with the observed spottedness, but we find that they are partially connected to the retrieved field complexity. Conclusions. This field topology and the dominance of the poloidal field component, when compared to global magnetoconvection models for rapidly rotating young suns, could be explained by a turbulent dynamo, where differential rotation does not play a major role (so-called alpha(2)Omega(2) or alpha(2) dynamos) and axi- and non-axisymmetric modes are excited simultaneously. The complex equatorial magnetic field structure could arise from the twisted (helical) wreaths often seen in these simulations, while the polar feature would be connected to the mostly poloidal non-axisymmetric component that has a smooth spatial structure.
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- Mariz, FC, et al.
(författare)
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Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines
- 2020
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Ingår i: NPJ vaccines. - : Springer Science and Business Media LLC. - 2059-0105. ; 5:1, s. 14-
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Tidskriftsartikel (refereegranskat)abstract
- We performed an independent comparison of neutralizing and cross-neutralizing antibody (ab) levels seven months after initiation of three-dose, six-month vaccination schedules with the bivalent and quadrivalent human papillomavirus (HPV) vaccines in adolescent Finnish and Indian females, respectively. We used a semi-automated Pseudovirion-Based Neutralization Assay and observed significantly higher HPV16/18 peak ab-levels in bivalent as compared to quadrivalent vaccine recipients. Bivalent vaccine induced cross-neutralizing HPV31/33/45/52/58 antibodies significantly more frequently and to higher levels than the quadrivalent vaccine. The correlation of bivalent vaccine-induced HPV45 ab-levels with HPV16/18 ab-levels was stronger than that of corresponding quadrivalent vaccine-induced ab-levels, suggesting a qualitatively different cross-reactive response. Our findings on the comparison of the immunogenicity of two HPV vaccine tested in two different populations indicate that further head-to-head studies are warranted.
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- Willamo, T., et al.
(författare)
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Zeeman-Doppler imaging of five young solar-type stars
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 659
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Tidskriftsartikel (refereegranskat)abstract
- Context. The magnetic activity of the Sun changes with the solar cycle. Similar cycles are found in other stars as well, but their details are not known to a similar degree. Characterising stellar magnetic cycles is important for the understanding of the stellar and solar dynamos that are driving the magnetic activity.Aims. We present spectropolarimetric observations of five young, solar-type stars and compare them to previous observations, with the aim to identify and characterise stellar equivalents of the solar cycle.Methods. We use Zeeman-Doppler imaging (ZDI) to map the surface magnetic field and brightness of our targets. The magnetic field is decomposed into spherical harmonic expansions, from which we report the strengths of the axisymmetric versus non-axisymmetric and poloidal versus toroidal components, and we compare them to the Rossby numbers of the stars.Results. We present five new ZDI maps of young, solar-type stars from December 2017. Of special interest is the case of V1358 Ori, which had gone through a polarity reversal between our observations and earlier ones. A less evident polarity reversal might also have occurred in HD 35296. There is a preference for a more axisymmetric field, and possibly a more toroidal field, for the more active stars with lower Rossby number, but a larger sample should be studied to draw any strong conclusions from this. For most of the individual stars, the amounts of toroidal and poloidal field have stayed on levels similar to those in earlier observations.Conclusions. We find evidence for a magnetic polarity reversal having occurred in V1358 Ori. An interesting target for future observations is I1 Ori, which may have a short magnetic cycle of a few years. The correlation between the brightness maps and the magnetic field is mostly poor, which could indicate the presence of small-scale magnetic features of different polarities that cancel one another out and are thus not resolved in our maps.
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