| 1. |
- Lehtonen, K. K., et al.
(författare)
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The BEEP project in the Baltic Sea: Overview of results and outline for a regional biological effects monitoring strategy
- 2006
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Ingår i: Marine Pollution Bulletin. - : Elsevier BV. - 0025-326X. ; 53:8-9, s. 523-537
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Tidskriftsartikel (refereegranskat)abstract
- Field studies in the framework of the EU funded BEEP project (Biological Effects of Environmental Pollution in Marine Coastal Ecosystems, 2001-2004) aimed at validating and intercalibrating a battery of biomarkers of contaminant exposure and effects in selected indicator species in the Mediterranean, the North Atlantic and the Baltic Seas. Major strategic goals of the BEEP project were the development of a sensitive and cost-efficient biological effects monitoring approach, delivery of information and advice to end-user groups, and the implementation of a network of biomarker researchers around Europe. Based on the main results obtained in the Baltic Sea component of the BEEP the present paper summarises and assesses the applicability of biomarkers for different regions and species in this sea area. Moreover, a general strategy and some practical considerations for the monitoring of biological effects in the Baltic Sea are outlined. (c) 2006 Elsevier Ltd. All rights reserved.
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| 3. |
- Kujala, M, et al.
(författare)
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SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney
- 2005
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Ingår i: Nephron. Experimental nephrology. - : S. Karger AG. - 1660-2129. ; 101:2, s. E50-E58
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Tidskriftsartikel (refereegranskat)abstract
- <i>Background:</i> The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species. They are expressed in kidney, but their exact localization in human kidney has not been studied. We therefore examined SLC26A6 and A7 expression in human kidneys. <i>Methods:</i> The localization of SLC26A6 and A7 in different segments of human nephrons was studied by RT-PCR and immunohistochemistry by comparing to the tubular markers PNRA, CD10, Tamm-Horsfall antigen, high molecular weight cytokeratin, CK7, AQP2 and H<sup>+</sup>V-ATPase. <i>Results:</i> In human kidney, SLC26A6 is expressed in distal segments of proximal tubules, parts of the thin and thick ascending limbs of Henle’s loops, macula densa, distal convoluted tubules and a subpopulation of intercalated cells of collecting ducts. SLC26A7 is expressed in extraglomerular mesangial cells and a subpopulation of intercalated cells of collecting ducts. <i>Conclusion:</i> Our results show that in human kidney SLC26A6 and A7 have a distinct, partially overlapping expression in distal segments of nephrons. The distribution partly differs from that found previously in rodent kidneys.
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