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Träfflista för sökning "WFRF:(Leibiger B) srt2:(2010-2014)"

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1.	Gerdes, JM, et al. (author) Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents 2014 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 5308- Journal article (peer-reviewed)
2.	Kohler, M, et al. (author) One-step purification of functional human and rat pancreatic alpha cells 2012 In: Integrative biology : quantitative biosciences from nano to macro. - : Oxford University Press (OUP). - 1757-9708. ; 4:2, s. 209-219 Journal article (peer-reviewed)
3.	Leibiger, B, et al. (author) Glucagon regulates its own synthesis by autocrine signaling 2012 In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 109:51, s. 20925-20930 Journal article (peer-reviewed)abstract Peptide hormones are powerful regulators of various biological processes. To guarantee continuous availability and function, peptide hormone secretion must be tightly coupled to its biosynthesis. A simple but efficient way to provide such regulation is through an autocrine feedback mechanism in which the secreted hormone is “sensed” by its respective receptor and initiates synthesis at the level of transcription and/or translation. Such a secretion–biosynthesis coupling has been demonstrated for insulin; however, because of insulin’s unique role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exception rather than a more generally used mechanism. Here we provide evidence of a secretion–biosynthesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels. We show that glucagon, secreted by the pancreatic α cell, up-regulates the expression of its own gene by signaling through the glucagon receptor, PKC, and PKA, supporting the more general applicability of an autocrine feedback mechanism in regulation of peptide hormone synthesis.
4.	Leibiger, B, et al. (author) Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion 2010 In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 24:6, s. 1824-1837 Journal article (peer-reviewed)
5.	Leibiger, B, et al. (author) Knock-down of PI3K-C2 alpha leads to increased proliferation of pancreatic beta cells 2010 In: DIABETOLOGIA. - 0012-186X. ; 53, s. S219-S219 Conference paper (other academic/artistic)
6.	Leibiger, B, et al. (author) PI3K-C2 alpha regulates proliferation and differentiation of pancreatic beta cells 2011 In: DIABETOLOGIA. - 0012-186X. ; 54, s. S25-S25 Conference paper (other academic/artistic)
7.	Lo, JC, et al. (author) ADIPSIN IS AN ADIPOCYTOKINE DYSREGULATED IN OBESITY/METABOLIC SYNDROME THAT SUSTAINS CARDIOVASCULAR HEALTH 2014 In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - 0735-1097. ; 63:12, s. A2144-A2144 Conference paper (other academic/artistic)
8.	Lo, JC, et al. (author) Adipsin is an adipokine that improves β cell function in diabetes 2014 In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 158:1, s. 41-53 Journal article (peer-reviewed)
9.	Moede, T, et al. (author) Glucagon stimulates glucagon gene transcription in mouse and human islets by an autocrine feedback loop 2010 In: DIABETOLOGIA. - 0012-186X. ; 53, s. S214-S215 Conference paper (other academic/artistic)
10.	Moede, T, et al. (author) Insulin stimulation leads to oscillatory interactions between insulin receptor B-type and PI3K-C2 alpha or Shc in pancreatic beta cells 2011 In: DIABETOLOGIA. - 0012-186X. ; 54, s. S193-S193 Conference paper (other academic/artistic)

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Result 1-10 of 12

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Type of publication: journal article (7); conference paper (5)

Type of content: other academic/artistic (6); peer-reviewed (6)

Author/Editor: Berggren, PO (12); Moede, T (11); Leibiger, B (10); Leibiger, IB (9); Leibiger, I (3); Ricordi, C (2); show more...; Cohen, P (2); Walter, B. (2); Lo, JC (2); Spiegelman, BM (2); Guzman, J (2); Kelly, ME (2); Fornoni, A (2); Jeon, J (2); Faul, C (2); Maiguel, D (2); Villarreal, R (2); Mundel, P (2); Merscher-Gomez, S (2); Ljubicic, S (2); Tibell, A (1); OSTENSON, CG (1); Kohler, M (1); Kern, M. (1); Bluher, M. (1); Juntti-Berggren, L (1); Dietrich, A. (1); Moruzzi, N (1); Barker, CJ (1); Rajasekaran, SS (1); Dare, E (1); Cinti, S (1); Uhles, S (1); Xiong, Y (1); Gerdes, JM (1); Danial, NN (1); Kaiser, D. (1); Blueher, M (1); Christou-Savina, S (1); Karlsson-Edlund, P (1); Beales, PL (1); Domin, J (1); Ali, MY (1); Muhandiramlage, TP (1); Sanchez, PV (1); Creveaux, M (1); Chatterjee-Bhowmick, ... (1); Banks, A (1); Flier, J (1); Danial, N (1); show less...

University: Karolinska Institutet (12)

Language: English (12)

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