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Metabolic network a...
Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission
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- Stockbauer, Anna (författare)
- Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany
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- Beyer, Leonie (författare)
- Ludwig Maximilians Univ Munchen, Germany
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- Huber, Maria (författare)
- Ludwig Maximilians Univ Munchen, Germany
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visa fler...
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- Kreuzer, Annika (författare)
- Ludwig Maximilians Univ Munchen, Germany
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- Palleis, Carla (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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- Katzdobler, Sabrina (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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- Rauchmann, Boris-Stephan (författare)
- Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany
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- Morbelli, Silvia (författare)
- IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy
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- Chincarini, Andrea (författare)
- Natl Inst Nucl Phys INFN, Italy
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- Bruffaerts, Rose (författare)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium; Hasselt Univ, Belgium; Univ Antwerp, Belgium
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- Vandenberghe, Rik (författare)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium
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- Kramberger, Milica G. (författare)
- Univ Med Ctr, Slovenia; Univ Med Ctr, Slovenia
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- Trost, Maja (författare)
- Univ Med Ctr, Slovenia; Univ Med Ctr, Slovenia; Univ Ljubljana, Slovenia
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- Garibotto, Valentina (författare)
- Univ Geneva, Switzerland; Univ Geneva, Switzerland
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- Nicastro, Nicolas (författare)
- Geneva Univ Hosp, Switzerland
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- Lathuiliere, Aurelien (författare)
- Geneva Univ Hosp, Switzerland
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- Lemstra, Afina W. (författare)
- Vrije Univ Amsterdam, Netherlands
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- van Berckel, Bart N. M. (författare)
- Vrije Univ Amsterdam, Netherlands
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- Pilotto, Andrea (författare)
- Univ Brescia, Italy; FERB ONLUS S Isidoro Hosp, Italy
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- Padovani, Alessandro (författare)
- Univ Brescia, Italy
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- Ochoa-Figueroa, Miguel A. (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US,Region Östergötland, Röntgenkliniken i Linköping
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- Davidsson, Anette (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
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- Camacho, Valle (författare)
- Univ Autonoma Barcelona, Spain
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- Peira, Enrico (författare)
- Natl Inst Nucl Phys INFN, Italy; Univ Genoa, Italy
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- Bauckneht, Matteo (författare)
- IRCCS Osped Policlin San Martino, Italy
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- Pardini, Matteo (författare)
- Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
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- Sambuceti, Gianmario (författare)
- IRCCS Osped Policlin San Martino, Italy; Univ Genoa, Italy
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- Aarsland, Dag (författare)
- Stavanger Univ Hosp, Norway; Kings Coll London, England
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- Nobili, Flavio (författare)
- Univ Genoa, Italy; IRCCS Osped Policlin San Martino, Italy
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- Gross, Mattes (författare)
- Ludwig Maximilians Univ Munchen, Germany
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- Voeglein, Jonathan (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany
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- Perneczky, Robert (författare)
- German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany; Ludwig Maximilians Univ Munchen, Germany; Univ Sheffield, England; Imperial Coll, England
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- Pogarell, Oliver (författare)
- Ludwig Maximilians Univ Munchen, Germany
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- Buerger, Katharina (författare)
- German Ctr Neurodegenerat Dis DZNE, Germany; Univ Munich, Germany
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- Franzmeier, Nicolai (författare)
- German Ctr Neurodegenerat Dis DZNE, Germany
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- Danek, Adrian (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany
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- Levin, Johannes (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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- Hoeglinger, Guenter U. (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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- Bartenstein, Peter (författare)
- Ludwig Maximilians Univ Munchen, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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- Cumming, Paul (författare)
- Univ Bern, Switzerland; Queensland Univ Technol, Australia; Queensland Univ Technol, Australia
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- Rominger, Axel (författare)
- Ludwig Maximilians Univ Munchen, Germany; Univ Bern, Switzerland
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- Brendel, Matthias (författare)
- Ludwig Maximilians Univ Munchen, Germany; German Ctr Neurodegenerat Dis DZNE, Germany; Munich Cluster Syst Neurol SyNergy, Germany
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(creator_code:org_t)
- SPRINGER, 2024
- 2024
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : SPRINGER. - 1619-7070 .- 1619-7089. ; 51:4, s. 1023-1034
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, multiple system atrophy) at individual patient level via principal component analysis (PCA).Methods FDG-PETs of subjects with probable or possible DLB (n = 22) without significant dopamine deficiency (z-score < 2 in putamen binding loss on DaT-SPECT compared to healthy controls (HC)) were scaled by global-mean, prior to volume-of-interest-based analyses of relative glucose metabolism. Single region metabolic changes and network connectivity changes were compared against HC (n = 23) and against DLB subjects with significant dopamine deficiency (n = 86). PCA was applied to test discrimination of patients with DLB from disease controls (n = 101) at individual patient level.Results Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (R2 = 0.597, p < 0.01). A PCA trained by DLB patients with dopamine deficiency and HC discriminated DLB patients without significant dopaminergic loss from other neurodegenerative parkinsonian disorders at individual patient level (area-under-the-curve (AUC): 0.912).Conclusion Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Dementia with Lewy bodies; FDG-PET; Metabolic connectivity; DaT-Scan
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Stockbauer, Anna
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Beyer, Leonie
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Huber, Maria
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Kreuzer, Annika
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Palleis, Carla
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Katzdobler, Sabr ...
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visa fler...
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Rauchmann, Boris ...
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Morbelli, Silvia
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Chincarini, Andr ...
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Bruffaerts, Rose
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Vandenberghe, Ri ...
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Kramberger, Mili ...
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Trost, Maja
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Garibotto, Valen ...
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Nicastro, Nicola ...
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Lathuiliere, Aur ...
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Lemstra, Afina W ...
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van Berckel, Bar ...
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Pilotto, Andrea
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Padovani, Alessa ...
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Ochoa-Figueroa, ...
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Davidsson, Anett ...
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Camacho, Valle
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Peira, Enrico
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Bauckneht, Matte ...
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Pardini, Matteo
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Sambuceti, Gianm ...
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Aarsland, Dag
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Nobili, Flavio
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Gross, Mattes
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Voeglein, Jonath ...
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Perneczky, Rober ...
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Pogarell, Oliver
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Buerger, Kathari ...
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Franzmeier, Nico ...
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Danek, Adrian
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Levin, Johannes
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Hoeglinger, Guen ...
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Bartenstein, Pet ...
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Cumming, Paul
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Rominger, Axel
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Brendel, Matthia ...
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