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- Maddison, G. P., et al.
(författare)
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Contrasting H-mode behaviour with deuterium fuelling and nitrogen seeding in the all-carbon and metallic versions of JET
- 2014
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 54:7, s. 073016-
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Tidskriftsartikel (refereegranskat)abstract
- The former all-carbon wall on JET has been replaced with beryllium in the main torus and tungsten in the divertor to mimic the surface materials envisaged for ITER. Comparisons are presented between type I H-mode characteristics in each design by examining respective scans over deuterium fuelling and impurity seeding, required to ameliorate exhaust loads both in JET at full capability and in ITER. Attention is focused upon a common high-triangularity, single-null divertor configuration at 2.5 MA, q(95) approximate to 3.5 yielding the most robust all-C performance. Contrasting results between the alternative linings are found firstly in unseeded plasmas, for which purity is improved and intrinsic radiation reduced in the ITER-like wall (ILW) but normalized energy confinement is approximate to 30% lower than in all-C counterparts, owing to a commensurately lower (electron) pedestal temperature. Divertor recycling is also radically altered, with slower, inboard-outboard asymmetric transients at ELMs and spontaneous oscillations in between them. Secondly, nitrogen seeding elicits opposite responses in the ILW to all-C experience, tending to raise plasma density, reduce ELM frequency, and above all to recover (electron) pedestal pressure, hence global confinement, almost back to previous levels. A hitherto unrecognized role of light impurities in pedestal stability and dynamics is consequently suggested. Thirdly, while heat loads on the divertor outboard target between ELMs are successfully reduced in proportion to the radiative cooling and ELM frequency effects of N in both wall environments, more surprisingly, average power ejected by ELMs also declines in the same proportion for the ILW. Detachment between transients is simultaneously promoted. Finally, inter-ELM W sources in the ILW divertor tend to fall with N input, although core accumulation possibly due to increased particle confinement still leads to significantly less steady conditions than in all-C plasmas. This limitation of ILW H-modes so far will be readdressed in future campaigns to continue progress towards a fully integrated scenario suitable for D-T experiments on JET and for 'baseline' operation on ITER. The diverse changes in behaviour between all-C and ILW contexts demonstrate essentially the strong impact which boundary conditions and intrinsic impurities can have on tokamak-plasma states.
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| 4. |
- Antoniou, Antonis C., et al.
(författare)
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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:16, s. 3304-3321
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Tidskriftsartikel (refereegranskat)abstract
- Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women.
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| 7. |
- Beurskens, M. N. A., et al.
(författare)
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Global and pedestal confinement in JET with a Be/W metallic wall
- 2014
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 54:4, s. 043001-
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Tidskriftsartikel (refereegranskat)abstract
- Type I ELMy H-mode operation in JET with the ITER-like Be/W wall (JET-ILW) generally occurs at lower pedestal pressures compared to those with the full carbon wall (JET-C). The pedestal density is similar but the pedestal temperature where type I ELMs occur is reduced and below to the so-called critical type I-type III transition temperature reported in JET-C experiments. Furthermore, the confinement factor H-98(y,H- 2) in type I ELMy H-mode baseline plasmas is generally lower in JET-ILWcompared to JET-C at low power fractions Ploss/P-thr,(08)< 2 (where P-loss is (P-in-dW/dt), and P-thr,(08) the L-H power threshold from Martin et al 2008 (J. Phys. Conf. Ser. 123 012033)). Higher power fractions have thus far not been achieved in the baseline plasmas. At Ploss/P-thr,P- 08 > 2, the confinement in JET-ILW hybrid plasmas is similar to that in JET-C. A reduction in pedestal pressure is the main reason for the reduced confinement in JET-ILW baseline ELMy H-mode plasmas where typically H-98((y, 2)) = 0.8 is obtained, compared to H-98((y, 2)) = 1.0 in JET-C. In JET-ILW hybrid plasmas a similarly reduced pedestal pressure is compensated by an increased peaking of the core pressure profile resulting in H-98((y, 2)) <= 1.25. The pedestal stability has significantly changed in high triangularity baseline plasmas where the confinement loss is also most apparent. Applying the same stability analysis for JET-C and JET-ILW, the measured pedestal in JET-ILW is stable with respect to the calculated peeling-ballooning stability limit and the ELM collapse time has increased to 2ms from typically 200 mu s in JET-C. This indicates that changes in the pedestal stability may have contributed to the reduced pedestal confinement in JET-ILW plasmas. A comparison of EPED1 pedestal pressure prediction with JET-ILW experimental data in over 500 JET-C and JET-ILW baseline and hybrid plasmas shows a good agreement with 0.8 < (measured p(ped))/(predicted p(ped), EPED) < 1.2, but that the role of triangularity is generally weaker in the JET-ILW experimental data than in the model predictions.
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| 8. |
- Beurskens, M. N. A., et al.
(författare)
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The effect of a metal wall on confinement in JET and ASDEX Upgrade
- 2013
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 55:12, s. 124043-
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Tidskriftsartikel (refereegranskat)abstract
- In both JET and ASDEX Upgrade (AUG) the plasma energy confinement has been affected by the presence of a metal wall by the requirement of increased gas fuelling to avoid tungsten pollution of the plasma. In JET with a beryllium/tungsten wall the high triangularity baseline H-mode scenario (i.e. similar to the ITER reference scenario) has been the strongest affected and the benefit of high shaping to give good normalized confinement of H-98 similar to 1 at high Greenwald density fraction of f(GW) similar to 0.8 has not been recovered to date. In AUG with a full tungsten wall, a good normalized confinement H-98 similar to 1 could be achieved in the high triangularity baseline plasmas, albeit at elevated normalized pressure beta(N) > 2. The confinement lost with respect to the carbon devices can be largely recovered by the seeding of nitrogen in both JET and AUG. This suggests that the absence of carbon in JET and AUG with a metal wall may have affected the achievable confinement. Three mechanisms have been tested that could explain the effect of carbon or nitrogen (and the absence thereof) on the plasma confinement. First it has been seen in experiments and by means of nonlinear gyrokinetic simulations (with the GENE code), that nitrogen seeding does not significantly change the core temperature profile peaking and does not affect the critical ion temperature gradient. Secondly, the dilution of the edge ion density by the injection of nitrogen is not sufficient to explain the plasma temperature and pressure rise. For this latter mechanism to explain the confinement improvement with nitrogen seeding, strongly hollow Z(eff) profiles would be required which is not supported by experimental observations. The confinement improvement with nitrogen seeding cannot be explained with these two mechanisms. Thirdly, detailed pedestal structure analysis in JET high triangularity baseline plasmas have shown that the fuelling of either deuterium or nitrogen widens the pressure pedestal. However, in JET-ILW this only leads to a confinement benefit in the case of nitrogen seeding where, as the pedestal widens, the obtained pedestal pressure gradient is conserved. In the case of deuterium fuelling in JET-ILW the pressure gradient is strongly degraded in the fuelling scan leading to no net confinement gain due to the pedestal widening. The pedestal code EPED correctly predicts the pedestal pressure of the unseeded plasmas in JET-ILW within +/- 5%, however it does not capture the complex variation of pedestal width and gradient with fuelling and impurity seeding. Also it does not predict the observed increase of pedestal pressure by nitrogen seeding in JET-ILW. Ideal peeling ballooning MHD stability analysis shows that the widening of the pedestal leads to a down shift of the marginal stability boundary by only 10-20%. However, the variations in the pressure gradient observed in the JET-ILW fuelling experiment is much larger and spans a factor of more than two. As a result the experimental points move from deeply unstable to deeply stable on the stability diagram in a deuterium fuelling scan. In AUG-W nitrogen seeded plasmas, a widening of the pedestal has also been observed, consistent with the JET observations. The absence of carbon can thus affect the pedestal structure, and mainly the achieved pedestal gradient, which can be recovered by seeding nitrogen. The underlying physics mechanism is still under investigation and requires further understanding of the role of impurities on the pedestal stability and pedestal structure formation.
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| 10. |
- Loarte, A., et al.
(författare)
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Plasma density and temperature evolution following the H-mode transition at JET and implications for ITER
- 2013
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Ingår i: Nuclear Fusion. - : Institute of Physics (IOP). - 0029-5515 .- 1741-4326. ; 53:8, s. 083031-
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Tidskriftsartikel (refereegranskat)abstract
- The build-up of plasma parameters following the H-mode transition in JET has been analysed in view of its consequences for the alpha power evolution in the access to burning plasma conditions in ITER. JET experiments show that the build-up of plasma temperature both at the plasma core and the plasma edge occurs in timescales comparable to the energy confinement time. In contrast, the evolution of the edge and core densities differs strongly depending on the level of plasma current in the discharge and of the associated NBI penetration. For higher plasma current H-mode discharges (I-p > 2.0-2.5 MA, depending on plasma shape), with naturally higher plasma densities for which NBI penetration is poorer, the core density evolves in much longer timescales than the edge density leading to the formation of rather hollow density profiles. These hollow density profiles persist for timescales of several energy confinement times until they are usually terminated by a sawtooth. Modelling of the JET experiments with JETTO shows that the density build-up following the H-mode transition can be described with a purely diffusive model, despite the low collisionalities of high current H-mode plasmas at JET. The consequences of these JET experimental/modelling findings for the access to burning plasma conditions in the ITER Q(DT) = 10 scenario are presented.
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