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Träfflista för sökning "WFRF:(Li C. H.) srt2:(1995-1999)"

Sökning: WFRF:(Li C. H.) > (1995-1999)

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  • Kockum, Ingrid, et al. (författare)
  • Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus
  • 1996
  • Ingår i: Hormone and Metabolic Research. - : Georg Thieme Verlag KG. - 0018-5043 .- 1439-4286. ; 28:7, s. 344-347
  • Tidskriftsartikel (refereegranskat)abstract
    • Two large population-based case-control studies are reviewed. The aim is to determine the effects of HLA, other genetic factors and immune markers (ICA, IAA and GAD65Ab) on the age at onset of insulin-dependent diabetes mellitus (IDDM) in 0-34 year olds. The primary HLA risk gene sequence for IDDM was difficult to identify because of the low recombination frequency within the HLA region. The frequency of the DR3-DQA1 * 0501-DQB1 * 0201 haplotype and the DR3-DQA1 * 0501 DQB1 * 0201 (DQ2)/DR4-DQA1 * 0301-DQB1 * 0302 (DQ8) genotype were higher among patients diagnosed before the age of 10 compared with those diagnosed after the age of 30. The negatively associated haplotype, DR15-DQA1 * 0102-DQB1 * 0602 was absent before the age of 10, but the frequency increased with increasing age at onset. The IDDM2 gene representing the variable number of tandem repeat (VNTR) sequences and 5' of the insulin gene on chromosome 11 were associated with IDDM since homozygous short VNTR was positive but not homozygous, and heterozygous long VNTR was negatively associated with the disease. The diagnostic sensitivity and specificity of GAD65 (GA65Ab) and insulin (IAA) autoantibodies varied with the age at onset and gender. GAD65Ab had the highest sensitivity (> 80%) in patients older than 20 years of age with no difference in gender. The lowest sensitivity (54%) was in 0-10 year old boys, while age did not affect the sensitivity in girls. In contrast, the sensitivity of IAA was highest (46%) before the age of 15 but decreased thereafter as did the sensitivity for ICA. Classification of patients who develop IDDM above 20-25 years of age was inadequate since many patients classified with NIDDM either had GAD65Ab or ICA or developed these antibodies after 1-2 years of NIDDM. We conclude that not only age but also gender affects the risk for IDDM associated with HLA, other IDDM genes as well as commonly used immunological markers for IDDM.
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  • Tang, C. A., et al. (författare)
  • A theoretical model for Kaiser effect in rocks
  • 1997
  • Ingår i: Pure and Applied Geophysics. - : Springer Science and Business Media LLC. - 0033-4553 .- 1420-9136. ; 150:2, s. 203-215
  • Tidskriftsartikel (refereegranskat)abstract
    • The mechanism of Kaiser effect was studied with the aid of a damage model for rock. Recognizing that the AE counts are transient elastic waves due to local damage of the rock, the quantitative relation between AE counts and statistical distribution of the local strength of the rock has been established. Subsequently, according to Damage Theory, an expression for Kaiser Effect under uniaxial stress state was derived from the model. This is found to be in good agreement with the experimental results.
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