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Träfflista för sökning "WFRF:(Li M.) srt2:(1995-1999)"

Sökning: WFRF:(Li M.) > (1995-1999)

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  • von Euler, Mia, 1967-, et al. (författare)
  • No protective effect of the NMDA antagonist memantine in experimental spinal cord injuries
  • 1997
  • Ingår i: Journal of Neurotrauma. - New York, USA : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 14:1, s. 53-61
  • Tidskriftsartikel (refereegranskat)abstract
    • We have investigated the effect of memantine, a clinically used NMDA receptor antagonist, in two experimental animals models of spinal cord injury. The lesions were laser-induced photothrombosis to induce focal spinal cord ischemia and clip compression to mimic traumatic spinal cord injury. Pre- or posttreatment of rats with a dose of memantine (20 mg/kg ip) previously shown to be neuroprotective in cerebral ischemia, failed to affect both the neurological and morphological outcome of ischemic spinal cord injury. Likewise, memantine had no effects on neurological and morphological outcome after experimental traumatic injury. In view of the regional heterogeneity of NMDA receptors, the affinity of memantine for spinal cord NMDA receptors was also determined by studying displacement of [3H] (+)-5-methyl-10,11-dihydro-5-H-dibenzo[a,d]cyclohepten-5-10-imine (MK-801) to rat and human spinal cord homogenates. We found that memantine had an affinity for NMDA receptors in the spinal cord (Ki = 0.58 microM) that was significantly lower compared to that of the cerebral cortex (Ki = 0.23 microM) and that the affinity for NMDA receptors in human spinal cord was even lower. We conclude that in view of available data, memantine should not be chosen for clinical studies on neuroprotection in spinal cord injuries and that the lack of protective effect is most likely due to insufficient affinity of memantine for spinal cord NMDA receptors.
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  • Gadea, A, et al. (författare)
  • Magnetic rotation in the Sn-105 nucleus
  • 1997
  • Ingår i: PHYSICAL REVIEW C-NUCLEAR PHYSICS. - : AMER INST PHYSICS. ; 55:1, s. R1-R4
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The structure of Sn-105 has been investigated through the Cr-50(Ni-58,2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme a regular sequence of dipole transitions has been found. The states of the dipole ba
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  • Gadea, A, et al. (författare)
  • Shears band in the Sn-105 nucleus
  • 1997
  • Ingår i: ZEITSCHRIFT FUR PHYSIK A-HADRONS AND NUCLEI. - : SPRINGER VERLAG. ; 358:2, s. 193-194
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The structure of Sn-105 has been investigated through the Cr-50(Ni-58, 2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme, a regular sequence of dipole transitions has been found. The experimental results
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  • Resultat 1-10 av 114

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