| 1. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 2. |
- Kristan, Matej, et al.
(författare)
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The Sixth Visual Object Tracking VOT2018 Challenge Results
- 2019
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Ingår i: Computer Vision – ECCV 2018 Workshops. - Cham : Springer Publishing Company. - 9783030110086 - 9783030110093 ; , s. 3-53
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis and a “real-time” experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. A long-term tracking subchallenge has been introduced to the set of standard VOT sub-challenges. The new subchallenge focuses on long-term tracking properties, namely coping with target disappearance and reappearance. A new dataset has been compiled and a performance evaluation methodology that focuses on long-term tracking capabilities has been adopted. The VOT toolkit has been updated to support both standard short-term and the new long-term tracking subchallenges. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website (http://votchallenge.net).
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| 3. |
- Marouli, Eirini, et al.
(författare)
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Rare and low-frequency coding variants alter human adult height
- 2017
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
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Tidskriftsartikel (refereegranskat)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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| 4. |
- Turcot, Valerie, et al.
(författare)
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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| 5. |
- Justice, Anne E., et al.
(författare)
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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
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Tidskriftsartikel (refereegranskat)abstract
- Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
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| 6. |
- Wessel, Jennifer, et al.
(författare)
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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
- 2015
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF = 1.4%) with lower FG (beta = -0.09 +/- 0.01 mmol l(-1), P = 3.4 x 10(-12)), T2D risk (OR[95% CI] = 0.86[0.76-0.96], P = 0.010), early insulin secretion (beta = -0.07 +/- 0.035 pmol(insulin) mmol(glucose)(-1), P = 0.048), but higher 2-h glucose (beta = 0.16 +/- 0.05 mmol l(-1), P = 4.3 x 10(-4)). We identify a gene-based association with FG at G6PC2 (p(SKAT) = 6.8 x 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF = 20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (beta = 0.02 +/- 0.004 mmol l(-1), P = 1.3 x 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
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| 7. |
- Zhao, Ruikai, et al.
(författare)
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Techno-economic analysis of carbon capture from a coal-fired power plant integrating solar-assisted pressure-temperature swing adsorption (PTSA)
- 2019
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Ingår i: Journal of Cleaner Production. - : ELSEVIER SCI LTD. - 0959-6526 .- 1879-1786. ; 214, s. 440-451
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a techno-economic study to seek the feasibility about the proposed system that integrating solar-assisted pressure-temperature swing adsorption (PTSA) into an 800MWe coal-fired power plant. Solar energy has the potential to supply thermal energy demand for carbon capture, which can avoid the energy consumption of the traditional method such as the steam extraction. The performance of the proposed system is largely affected by the climatic conditions and solar collector's types. The assessment criteria include carbon emission intensity (CEO, levelized cost of electricity (LCOE) and cost of CO2 avoidance (COA). By the parametric analysis, the results show that CEI of the novel system with solar thermal collectors is approximately 2g/kWh lower than that of the referenced power plant with CO2 adsorption capture. In addition, CEI of the novel system can be further decrease with the decline of desorption temperature, adsorption pressure and desorption pressure. For the sake of lower LCOE and COA, the prices of the power plant capacity, adsorbents and solar collectors should be reduced. Specifically, LCOE of the system with evacuated tube collector will be lower than that of the reference system with CO2 capture as the price of solar field is lower than 46.08 USD/m2.
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| 8. |
- Zhao, Ruikai, et al.
(författare)
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Thermodynamic exploration of temperature vacuum swing adsorption for direct air capture of carbon dioxide in buildings
- 2019
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Ingår i: Energy Conversion and Management. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0196-8904 .- 1879-2227. ; 183, s. 418-426
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Tidskriftsartikel (refereegranskat)abstract
- Abrupt climate change such as the loss of Arctic sea-ice area urgently needs negative emissions technologies. The potential application of direct air capture of carbon dioxide from indoor air and outdoor air in closed buildings or crowded places has been discussed in this paper. From the aspects of carbon reduction and indoor comfort, the ventilation system integrating a capture device is of great value in practical use. For ultra-dilute carbon dioxide sources, many traditional separation processes have no cost advantages, but adsorption technologies such as temperature vacuum swing adsorption is one of suitable methods. Thermodynamic exploration has been investigated regarding minimum separation work and second-law efficiency at various concentrations in the air. The influence of concentration, adsorption temperature, desorption temperature and desorption pressure on the energy efficiency has also been evaluated. Results show that the minimum separation work for the level of 400 ppm is approximately 20 kJ/mol. The optimal second-law efficiencies are 44.57%, 37.55% and 31.60%, respectively for 3000 ppm, 2000 ppm and 1000 ppm. It means that a high energy-efficiency capture device in buildings merits attention in the exploration of the possibility of approaching negative carbon buildings.
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| 9. |
- Li, Shuangjun, et al.
(författare)
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Entropy analysis on energy-consumption process and improvement method of temperature/vacuum swing adsorption (TVSA) cycle
- 2019
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Ingår i: Energy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0360-5442 .- 1873-6785. ; 179, s. 876-889
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Tidskriftsartikel (refereegranskat)abstract
- CO2 adsorption capture, which could be driven by various forms of energy, has been widely studied in recent years due to the equipment is easy to control with low energy consumption required. However, the existing research on the energy-efficiency aspects of temperature/vacuum swing adsorption (TVSA) for CO2 capture are primarily focus on the quantification of input energy in specific cases. As a classical concept in thermodynamics, entropy has been widely applied in researches on the energy conversion process, which could benefit an in-depth understanding on the mechanism of "heatgeneralized chemical energy" conversion. However, an integrated thermodynamic research framework, which could clarify how to conduct a reasonable energy-consumption analysis of TVSA, has not been established yet. In this paper, a simplified thermodynamic cycle of 4-step TVSA was established, with the assumption of CO2 in adsorbed phase as loop fluid. With the application of the thermodynamic research framework proposed in this paper, the entropy analysis on the thermodynamic cycle was conducted. This study is concerned with application of thermodynamics concept to the CO2 adsorption engineering, which is mainly based on classical thermodynamics but also relying on adsorption physics to supply insight into the energy conversion and energy-efficient mechanism of TVSA technologies.
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| 10. |
- Liang, Shuai, et al.
(författare)
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PAHs and soot formation in laminar partially premixed co-flow flames fuelled by PRFs at elevated pressures
- 2019
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Ingår i: Combustion and Flame. - : Elsevier BV. - 0010-2180. ; 206, s. 363-378
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated polycyclic aromatic hydrocarbons (PAHs)and soot formation characteristics in laminar jet flames fuelled by primary reference fuels (PRFs)at elevated pressures. Qualitative PAHs and quantitative soot profiles were acquired by using laser-induced fluorescence and laser-induced incandescence, respectively. The backpressure of flames ranged from 1 bar to 5 bar. Proper flames with the volume fraction of iso-octane in PRFs varying between 0% and 100% and flame equivalent ratio varying between 3.0 and 11.4 were stabilised in a pressurised chamber. The effects of backpressure, equivalent ratio and iso-octane ratio on PAHs and soot formation were evaluated. PAHs and soot formation can be promoted by increasing iso-octane ratio, equivalent ratio and backpressure. The data suggest that PAHs with large molecular size are more sensitive to the increase of backpressure compared with those with small molecular size. Backpressure played a positive role in the growth of PAHs size. The averaged soot volume fraction showed an approximate power-law relation with pressure. The measured averaged soot volume fraction was proportional to pn. Pressure exponent n was 1.34–2.17, 1.41–2.12 and 1.56–2.20 at equivalent ratios of 6.2, 8.5 and 11.4, respectively.
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