| 1. |
- Hibar, Derrek P., et al.
(författare)
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Novel genetic loci associated with hippocampal volume
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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| 2. |
- Li, Xinmin, et al.
(författare)
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A study on friction and wear reduction due to porosity in powder metallurgic gear materials
- 2017
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Ingår i: Tribology International. - : Elsevier. - 0301-679X .- 1879-2464. ; 110, s. 86-95
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Tidskriftsartikel (refereegranskat)abstract
- It has been widely acknowledged that controlled texturing on a surface can contribute to friction and wear reduction at lubricated sliding contact interfaces. This paper investigates the influence on friction and wear of different pore size distributions of powder metallurgy gear materials. The pore sizes are controlled by different densities of the powder metallurgic materials. Two different kinds of powder metallurgy (PM) gear materials were applied and a standard gear material are used as a reference. The friction and wear coefficients of PM materials sliding on PM materials increase with increasing pore size. The friction and wear coefficients of regular steel sliding on PM materials decrease with increasing pore size. No matter what the material of the disc, peeling is one of the main damage mechanisms of powder metallurgy pins with the biggest porosity.
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| 3. |
- Li, Xinmin, et al.
(författare)
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Pin-on-Disc Study of Tribological Performance of Standard and Sintered Gear Materials Treated with Triboconditioning Process: Pre-treatment by Pressure-induced Tribo-film formation
- 2017
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Ingår i: Tribology Transactions. - : Taylor & Francis Group. - 1040-2004 .- 1547-397X. ; 60:1, s. 47-57
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Tidskriftsartikel (refereegranskat)abstract
- oating is one of the innovative approaches used to improve the wear resistance and load-carrying capacity of surfaces in rolling-sliding contact, such as gears and rolling element bearings. In this study, the tribological performance of standard gear material (16MnCr5) and two kinds of powder metallurgy (PM) gear material (Distaloy AQ + 0.2% C and Astoloy 85Mo +0.2% C) with and without tribofilms formed by a pre-treatment were evaluated. Specimens treated with the pre-treatment and the substrate is subjected to pin-on-disc tests under boundary lubrication conditions. The friction and wear performance of the two different PM gear materials with the pre-treatment formed tribo-film were compared to RS-RS (16MnCr5 material disc and pin combination) for reference. It was found that the pre-treatment lowers the friction coefficient and enhances the wear resistance of pins because of the tribo-film formed. The tribo-film caused good running-in due to the existing of and Fe and W oxides. Mo-Mo (Astoloy 85Mo + 0.2% C material disc and pin combination) and Mo-RS (Astoloy 85Mo + 0.2% C disc and 16MnCr5 pin combination) showed statistically significant higher wear resistance.
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