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- Beecham, Ashley H, et al.
(författare)
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- 2013
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:11, s. 1353-60
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Tidskriftsartikel (refereegranskat)abstract
- Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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- Tamondong, Susan, et al.
(författare)
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Closing panel: Sharing wisdom and reflections on the enduring questions
- 2013
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper summarizes the discussion during the Closing Plenary Panel of the DIDR Conference. It revolves around three main themes: (i) Experiences and Views about Resettlement, (ii) Reflections on the DIDR Conference, and (iii) Suggestions for Future Work and Collaboration. The main author (Susan Tamondong) organized the Panel and facilitated the closing session. The Panelists considered to be “pioneers” in DIDR research and practice, shared their views on resettlement’s enduring questions, such as: What is adequate compensation? Can socio-cultural disruption be compensated? How do we deal with socio-cultural changes, damage and re-organization of communities? Can we compensate memories of life in the old community? Or, can a lost view of a community landscape and habitual prayer area by the mountain side be replaced? Do displaced people have the right to protest, or occupy a piece of public land? How do we deal with non-compensated public goods? In addition to these, specific questions were posed to the panel by the conference organizers which addressed the three themes (Themes 1, 2 and 3) of DIDR’s broader themes. Under these three themes, fifteen questions in total were divided and discussed by the panelists. Their views, including those from the audience are summarized in this paper, with some direct quotes from the speakers, as transcribed from video tapes. Contributions from Panel members who could not physically attend were read during the session.As a conclusion, DIDR is a broad and diverse social phenomenon that affects not only the lives and livelihoods of people but also the global environment exacerbated by climate change. There are no clear answers to date, but an urgent need to address the enduring questions, and more inclusive fora involving all stakeholders from affected peoples, civil society, to those causing and financing projects causing development displacement. DIDR needs more longitudinal studies to gain deeper understanding of displaced people, the role of social networks during reconstruction and the impact on their lives after displacement. These will provide academics and practitioners, not only insights whether human development also takes place, but also shape better ways of doing things, ideally without displacement and hopefully, to have answers to the enduring questions of resettlement .
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