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Träfflista för sökning "WFRF:(Lindau M) srt2:(2020-2021)"

Sökning: WFRF:(Lindau M) > (2020-2021)

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1.
  • Curbis, F, et al. (författare)
  • HIGHLIGHTS FROM THE CONCEPTUAL DESIGN REPORT OF THE SOFT X-RAY LASER AT MAX IV
  • 2021
  • Ingår i: Proceedings of IPAC2021.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The SXL (Soft X-ray Laser) project developed a conceptual design for a soft X-ray Free Electron Laser (FEL) in the 1-5 nm wavelength range, driven by the existing MAX IV 3 GeV linac. In this contribution we will focus on the FEL operation modes developed for the first phase of the project based on two different linac modes. The design work was supported by the Knut and Alice Wallenberg foundation and by several Swedish universities and organizations (
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2.
  • Lindau, Robert, et al. (författare)
  • Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells
  • 2021
  • Ingår i: Journal of Reproductive Immunology. - : Elsevier Ireland Ltd. - 0165-0378 .- 1872-7603. ; 146
  • Tidskriftsartikel (refereegranskat)abstract
    • During pregnancy, the semi-allogeneic nature of the foetus requires maternal immune adaption and acquisition of tolerance at the foetal-maternal interface. Macrophages with regulatory properties and regulatory T (Treg) cells are central in promoting foetal tolerance and are enriched in the decidua (the uterine endometrium during pregnancy). Although tissue-resident decidual stromal cells (DSC) have been implicated in regulatory functions, it is not known if they are able to induce the regulatory phenotype of macrophages and T-cells. In this study we report that maternally derived DSC are able to induce homeostatic M2 macrophages and Treg cells. CD14+ monocytes and CD4+ T-cells from healthy non-pregnant women were cultured in the presence or absence of conditioned medium (CM) from DSC isolated from 1st trimester and term placentas. DSC-CM alone was able to promote the survival of macrophages and to induce a regulatory CD14brightCD163+CD209+CD86dim phenotype, typical for decidual macrophages and similar to that induced by M-CSF. Interestingly, DSC-CM was also able to overrule the pro-inflammatory effects of GM-CSF by upregulating CD14, CD163 and CD209. Protein-profiling showed that M-CSF was secreted by DSC, and blocking of M-CSF partially reversed the M2 phenotype and reduced viability. DSC-CM also expanded CD25brightFoxp3+ Treg cells, an expansion that was abolished by a SMAD3-inhibitor, indicating the contribution of TGF-beta signaling. In conclusion, our findings collectively emphasize the role of tissue-resident stromal cells in shaping the tolerogenic environment at the foetal-maternal interface.
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