| 1. |
- Beijer, Kristina, et al.
(författare)
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Removal of pharmaceuticals and unspecified contaminants in sewage treatment effluents by activated carbon filtration and ozonation : Evaluation using biomarker responses and chemical analysis
- 2017
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Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 176, s. 342-351
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Tidskriftsartikel (refereegranskat)abstract
- Traces of active pharmaceutical ingredients (APIs) and other chemicals are demonstrated in effluents from sewage treatment plants (STPs) and they may affect quality of surface water and eventually drinking water. Treatment of effluents with granular activated carbon (GAC) or ozone to improve removal of APIs and other contaminants was evaluated at two Swedish STPs, Kappala and Uppsala (88 and 103 APIs analyzed). Biomarker responses in rainbow trout exposed to regular and additionally treated effluents were determined. GAC and ozone treatment removed 87-95% of the total concentrations of APIs detected. In Kappala, GAC removed 20 and ozonation (7 g O-3/m(3)) 21 of 24 APIs detected in regular effluent. In Uppsala, GAC removed 25 and ozonation (5.4 g O-3/m(3)) 15 of 25 APIs detected in effluent. GAC and ozonation also reduced biomarker responses caused by unidentified pollutants in STP effluent water. Elevated ethoxyresorufin-O-deethylase (EROD) activity in gills was observed in fish exposed to effluent in both STPs. Gene expression analysis carried out in Kappala showed increased concentrations of cytochrome P450 (CYP1A5 and CYP1C3) transcripts in gills and of CYP1As in liver of fish exposed to effluent. In fish exposed to GAC- or ozone-treated effluent water, gill EROD activity and expression of CYP1As and CYP1C3 in gills and liver were generally equal to or below levels in fish held in tap water. The joint application of chemical analysis and sensitive biomarkers proved useful for evaluating contaminant removal in STPs with new technologies.
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| 2. |
- Björlenius, Berndt, et al.
(författare)
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Pharmaceutical residues are widespread in Baltic Sea coastal and offshore waters – Screening for pharmaceuticals and modelling of environmental concentrations of carbamazepine
- 2018
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 633, s. 1496-1509
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Tidskriftsartikel (refereegranskat)abstract
- The consumption of pharmaceuticals worldwide coupled with modest removal efficiencies of sewage treatment plants have resulted in the presence of pharmaceuticals in aquatic systems globally. In this study, we investigated the environmental concentrations of a selection of 93 pharmaceuticals in 43 locations in the Baltic Sea and Skagerrak. The Baltic Sea is vulnerable to anthropogenic activities due to a long turnover time and a sensitive ecosystem in the brackish water. Thirty-nine of 93 pharmaceuticals were detected in at least one sample, with concentrations ranging between 0.01 and 80 ng/L. One of the pharmaceuticals investigated, the anti-epileptic drug carbamazepine, was widespread in coastal and offshore seawaters (present in 37 of 43 samples). In order to predict concentrations of pharmaceuticals in the sub-basins of the Baltic Sea, a mass balance-based grey box model was set up and the persistent, widely used carbamazepine was selected as the model substance. The model was based on hydrological and meteorological sub-basin characteristics, removal data from smaller watersheds and wastewater treatment plants, and statistics relating to population, consumption and excretion rate of carbamazepine in humans. The grey box model predicted average environmental concentrations of carbamazepine in sub-basins with no significant difference from the measured concentrations, amounting to 0.57-3.2 ng/L depending on sub-basin location. In the Baltic Sea, the removal rate of carbamazepine in seawater was estimated to be 6.2 10(-9) s(-1) based on a calculated half-life time of 3.5 years at 10 degrees C, which demonstrates the long response time of the environment to measures phasing out persistent or slowly degradable substances such as carbamazepine. Sampling, analysis and grey box modelling were all valuable in describing the presence and removal of carbamazepine in the Baltic Sea.
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| 3. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 4. |
- Fick, Jerker, et al.
(författare)
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Screening 2014 : Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A screening study was performed on selected pharmaceuticals and hormones. A total of 103 pharmaceuticals were analysed in 25 samples from a national program and 41 samples from a regional program. In addition, three hormones were analysed in 25 samples. The sampling programs were focused on samples from waste water treatment plants (WWTPs) and their receiving waters. Biota samples (perch) were also included in the study.45 pharmaceuticals were detected in the effluent of at least one WWTP, in levels that ranged from low ng/L up to 8.8 μg/L, with a median concentration of 52 ng/L. Caffeine was detected in highest concentrations followed by the beta-blocker metoprolol (1.8 μg/l). In WWTP sludge, 31 substances were detected. The antibiotic ciprofloxacine often dominated and was found in all sludge samples in the range 800-1800 μg/Kg dw. 44 pharmaceuticals were detected in surface water samples in the range from low ng/L up to 480 ng/L. Measured surface water concentrations were compared to critical environmental concentrations, i.e. the water concentration that is expected to cause a pharmacological effect in fish. This evaluation showed that eight pharmaceuticals in these samples may cause a pharmacological response in fish exposed to these waters. In biota (perch muscle) 17 substances were detected in concentrations up to 150 μg/Kg.Concentrations of hormones in WWTP effluents were <0.12 -0.76 ng/L for β-estradiol, <0.23–25 ng/L for estrone and <0.38–23 ng/L for ethinyl estradiol. Hormone measurements in perch bile suggested increased concentrations due to influence from WWTP emissions. Concentrations of hormones in three WWTP sludge’s were 2–7 ng/g dw for β-estradiol, 2–36 ng/g dw for estrone and 46–62 ng/g dw for ethinyl estradiol.
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| 5. |
- Gojkovic, Zivan, et al.
(författare)
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Northern green algae have the capacity to remove active pharmaceutical ingredients
- 2019
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Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier. - 0147-6513 .- 1090-2414. ; 170, s. 644-656
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Tidskriftsartikel (refereegranskat)abstract
- Eight recently isolated microalgal species from Northern Sweden and the culture collection strain Scenedesmus obliquus RISE (UTEX 417) were tested for their ability to remove 19 pharmaceuticals from growth medium upon cultivation in short light path, flat panel photobioreactors. While the growth of one algal species, Chlorellasorokiniana B1-1, was completely inhibited by the addition of pharmaceuticals, and the one of Scenedesmus sp. B2-2 was strongly inhibited, the other algal strains grew well and produced biomass.In general, lipophilic compounds were removed highly efficient from the culture medium by the microalgae (>70% in average within 2 days). The most lipophilic compounds Biperiden, Trihexyphenidyl, Clomipramine and Amitriptyline significantly accumulated in the biomass of most algal species, with a positive correlation between accumulation and their total biomass content. More persistent in the growth medium were hydrophilic compounds like Caffeine, Fluconazole, Trimetoprim, Codeine, Carbamazepin, Oxazepam and Tramadol, which were detected in amounts of above 60% in average after algal treatment.While Coelastrella sp. 3–4 and Coelastrum astroideum RW10 were most efficient to accumulate certain compounds in their biomass, two algae species, Chlorella vulgaris13-1 and Chlorella saccharophila RNY, were not only highly efficient in removing all 19 pharmaceuticals from the growth medium within 12 days, at the same time only small amounts of these compounds accumulated in their biomass allowing its further use. Chlorella vulgaris 13-1 was able to remove most compounds within 6 days of growth, while Chlorella saccharophila RNY needed 8–10 days.”Wild” Nordic microalgae therefore are able to remove active pharmaceutical ingredients, equally or more efficient than the investigated culture collection strain, thereby demonstrating their possible use in sustainable wastewater reclamation in Nordic conditions.
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| 6. |
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| 7. |
- Lindberg, Richard H., et al.
(författare)
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Online solid phase extraction liquid chromatography using bonded zwitterionic stationary phases and tandem mass spectrometry for rapid environmental trace analysis of highly polar hydrophilic compounds – Application for the antiviral drug Zanamivir
- 2015
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Ingår i: Talanta. - : Elsevier. - 0039-9140 .- 1873-3573. ; 141, s. 164-169
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Zanamivir (Za) is a highly polar and hydrophilic antiviral drug used for the treatment of influenza A viruses. Za has been detected in rivers of Japan and it's environmental occurrence has the risk of inducing antiviral resistant avian influenza viruses. In this study, a rapid automated online solid phase extraction liquid chromatography method using bonded zwitterionic stationary phases and tandem mass spectrometry (SPE/LC–MS/MS) for trace analysis of Za was developed. Furthermore, an internal standard (IS) calibration method capable of quantifying Za in Milli-Q, surface water, sewage effluent and sewage influent was evaluated. Optimum pre-extraction sample composition was found to be 95/5 v/v acetonitrile/water sample and 1% formic acid. The developed method showed acceptable linearities (r2≥0.994), filtration recovery (≥91%), and intra-day precisions (RSD≤16%), and acceptable and environmentally relevant LOQs (≤20 ng L−1). Storage tests showed no significant losses of Za during 20 days and +4/−20 °C (≤12%) with the exception of influent samples, which should be kept at −20 °C to avoid significant Za losses. The applicability of the method was demonstrated in a study on phototransformation of Za in unfiltered and filtered surface water during 28 days of artificial UV irradiation exposure. No significant (≤12%) phototransformation was found in surface water after 28 days suggesting a relatively high photostability of Za and that Za should be of environmental concern.
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| 8. |
- Lindberg, Richard, et al.
(författare)
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Occurrence and distribution of synthetic organic substances in boreal coniferous forest soils fertilized with hygienized municipal sewage sludge
- 2016
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Ingår i: Sewage and landfill leachate. - : Berghahn Books. - 9781771883955 - 9781771883948 ; , s. 121-145
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Bokkapitel (refereegranskat)abstract
- According to the Swedish government in 2006, the growth of the Swedish forest should increase 20% the following ten years, by means of fertilization, in order to replace the use of fossil fuels [1]. A similar conclusion was made during the evaluation of the Forest Bill 2007 [2]. In addition, the usage of such fertilizers in forest land should increase. The most essential nutrient for growth is nitrogen, and forest fertilization with nitrogen based fertilizers has been done over a long period [3]. An increase in growth, in the range of 15–20 m3·ha−1, is possible with a nitrogen dose of 150 kg·ha−1. Today, approximately 60,000 ha is fertilized in Sweden each year. On withdrawal of whole trees and rejected tops and branches, a larger nutrient loss is expected via needles, in comparison to the traditional collection of timber and pulpwood. In addition, the losses in growth due to nitrogen deficiency may also follow thinning [4]. Today, wood ash is recommended in order to compensate for the nutrient output following collection of tops and branches [5]. However, the ash lacks nitrogen and may cause growth reductions in less fertile soils [6].
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| 9. |
- Lindberg, Staffan I, 1969, et al.
(författare)
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Successful and Failed Episodes of Democratization: Conceptualization, Identification, and Description
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- What explains successful democratization? Answering this requires that researchers identify not only countries that successfully transitioned to democracy, but also those that began to liberalize—that initiated institutional reforms that move it towards democracy—but failed to transition. In this paper, we propose a solution that allows researchers more fully to capture the liberalization period and then classify these episodic events according to their outcome: successful, failed, or censored episodes of democratization. We identify the appropriate procedures and data necessary for operationalization of such episodes and present the first ever dataset of the full universe of democratization episodes 1900-2017, compare them to existing measures and assess construct validity. We also demonstrate the value of this approach showing how we can substantially improve upon what we know about democratization, including their relationship to development, state capacity, underlying temporal features, and the relationship between patterns of liberalization and whether a country successfully transitions to democracy.
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| 10. |
- Lindberg, Staffan I, 1969, et al.
(författare)
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Trust in Parliament
- 2017
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Ingår i: Journal of Public Affairs. - : Wiley. - 1472-3891. ; 17:2
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Tidskriftsartikel (refereegranskat)abstract
- Parliaments are—or should at least be—the central rule‐making institutions in democratic countries. If people do not have faith in the institution making the rules, it is less likely that people live by them. Consequently, it is beneficiary if trust in parliament is high. But it is also a normative good in itself. If the people do not trust the key institution whereby they can exercise “rule by the people over itself,” democracy itself is endangered. Secondly, trust levels should be reasonably even spread among relevant social and political groups in a society because parliament should ideally be a nonpartisan level playing field. However, because the majority in parliament typically chooses and sustains the acting government, one could say that legislatures in parliamentary democracies should not be level playing fields. According to this argument, there should be differences in trust in parliament between groups of individuals with varying political affiliations. Supporters of the majority in parliament should be expected to have higher trust in the legislature compared to citizens who voted for the opposition. We test our three hypotheses on data from some 80 countries participating in World Value Survey, either in Waves 5 or 6. We find that people in both new and established democracies harbor lower levels of trust than an intuitive interpretation of normative theory would lead us to expect. We also find that the attitudes of tens of thousands of citizens garnered from across 42 new and old democracies suggest that levels of average trust in groups of these societies are not as equally distributed, as a simple reading of democratic theory would have us to believe. In particular, individuals with a stronger interest in politics, and who are winners by the account of the last election, have statistically substantively relevant higher average levels of trust in parliament as an institution than do other citizens. The latter seems to us especially potentially problematic in particular for some of the new democracies where majority‐dominant parties manage to cling on to power over several election cycles. If what we find here were generally applicable also over several election cycles, we would expect the gap between winners and losers to widen and sediment and potentially sow the seeds of anti‐system movements opposed to democracy. Parliament is obviously a partisan creature in the eyes of most citizens in democracies. The level playing field idea does not fly.
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