| 1. |
- Vierth, Inge, 1959-, et al.
(författare)
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Impact of higher road vehicle dimensions on modal split : An ex-post analysis for Sweden
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Road freight transport is responsible for a considerable amount of congestion, noise and various forms of air pollution and policy instruments that reduce these negative external effects are therefore on top of many policy-makers’ lists. One of the discussed initiatives to reduce these externalities is to increase the maximum permissible weight and length of vehicle combinations. There are however concerns that higher vehicle dimensions will reduce road transport cost per tonne-kilometre and therefore lead both to a modal shift and to induced demand for road transportation.The extent to which the introduction of longer and heavier road vehicles attracts freight from competing modes is therefore a crucial question. The purpose of this study is to provide empirical evidence on this matter, by analyzing how the modal split in Sweden has developed following the adoption of increases in the maximum permissible vehicle dimensions.In this study, we utilize official statistics on freight transport by road, rail and water covering the period 1985 to 2013. We first investigate the extent to which LHVs were adopted following the increases in vehicle dimensions in 1990 and 1993. We then construct time-series for the modal split both on the aggregate level and the commodity group-level and analyze the short- and long-run development. We show that the share of tonne-kilometres and vehicle-kilometres performed by trucks with a load capacity above 40 tonnes increased substantially in the 1990s, which mainly came at the expense of the vehicles with the lowest capacity. This shows the high degree of incorporation of LHVs in the Swedish vehicle fleet. Our analysis of the aggregate modal split shows that both the rail and water shares were decreasing from 1985 up until 1995, when the trend reversed for rail transportation. In 2000, rail had regained the market share it had in 1990 and continued to increase in the 2000. Water transportation kept on losing market shares throughout the period of study. The modal share for road transportation developed much in the opposite way. The road share increased steadily between 1985–1990 and continued this way during most of the 1990s, until it stabilized around 60–65 percent. We also show that road and rail have experienced increases in the level of tonne-kilometres since 1990, which implies that the falling rail share between 1990 and 1995 was driven by higher tonne-kilometer growth rates for road transportation than for rail transportation.Our aggregated freight statistics do not allow us to attribute the development of the modal split during this period of study to a particular event such as the increase in maximum weights in 1990 and 1993. In particular, it is not possible to trace out substitution patterns between the transport modes. The weight reforms are likely to have mattered for the modal development, but so are the economic recession in the early 1990s, the railway sector reforms of 1996 and other structural changes in the transport market. What we do document is the lack of breaks in modal split trends at the weight reforms in 1990 and 1993. On the contrary, the share of each mode is continuing its long-term development.
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| 2. |
- Vierth, Inge, 1959-, et al.
(författare)
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Vehicle weight, modal split, and emissions : an ex-post analysis for Sweden
- 2018
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 10:6
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Tidskriftsartikel (refereegranskat)abstract
- This study combines official statistics on freight transportation and emissions to present the long-run development of the use of longer and heavier road vehicles (LHVs), modal split, road freight efficiency, and GHG emissions and air pollution following the increase in the maximum permissible vehicle weight in Sweden in 1990 and 1993. We find that LHVs were quickly incorporated in the vehicle fleet and that road freight efficiency of the largest vehicles increased after the reforms. There was no discernable break in modal split trends as the modal share for road continued its long-run development. We show that road transportation contributes by far the most to emission costs. The composition of the emissions from road freight changed after the weight reforms, with an increasing share of GHG-emissions.
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| 3. |
- Vierth, Inge, 1959-, et al.
(författare)
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Vehicle weight, modal split, and emissions : an ex-post analysis for Sweden
- 2018
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Ingår i: Sustainable Freight Transport. - : MDPI. - 9783038974352 - 9783038974369 ; , s. 57-71
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Bokkapitel (refereegranskat)abstract
- This study combines official statistics on freight transportation and emissions to present the long-run development of the use of longer and heavier road vehicles (LHVs), modal split, road freight efficiency, and GHG emissions and air pollution following the increase in the maximum permissible vehicle weight in Sweden in 1990 and 1993. We find that LHVs were quickly incorporated in the vehicle fleet and that road freight efficiency of the largest vehicles increased after the reforms. There was no discernable break in modal split trends as the modal share for road continued its long-run development. We show that road transportation contributes by far the most to emission costs. The composition of the emissions from road freight changed after the weight reforms, with an increasing share of GHG-emissions.
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| 4. |
- Arja, Katriann, et al.
(författare)
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Synthesis and Characterization of Novel Fluoro-glycosylated Porphyrins that can be Utilized as Theranostic Agents
- 2018
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Ingår i: ChemistryOpen. - : Wiley-VCH Verlagsgesellschaft. - 2191-1363. ; 7:7, s. 495-503
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Tidskriftsartikel (refereegranskat)abstract
- Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro-glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.
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| 5. |
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| 7. |
- Cenci Nilsson, Angela, et al.
(författare)
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Rodent models of impulsive compulsive behaviors in Parkinson's disease: how far have we reached?
- 2015
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Ingår i: Neurobiology of Disease. - : Elsevier BV. - 0969-9961. ; 82:aug 29, s. 561-573
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Forskningsöversikt (refereegranskat)abstract
- There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on uncertainties regarding, on one hand, the pathophysiology of these behaviors and, on the other hand, the experimental paradigms with which similar features can be induced in rodents. To help compose these uncertainties, we will here review the characteristics of ICBs in PD patients and then describe behavioral methods to approximate them in rodents. We will discuss both the challenges and the possibilities of applying these methods to animals with PD-like lesions, and review the recent progress made to this end. We will finally highlight important questions deserving further investigation. Rodent models having both face validity and construct validity to parkinsonian ICBs will be essential to further pathophysiological and therapeutic investigations into this important area.
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| 8. |
- Divakar, Pradeep K., et al.
(författare)
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Evolution of complex symbiotic relationships in a morphologically derived family of lichen-forming fungi
- 2015
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 208:4, s. 1217-1226
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Tidskriftsartikel (refereegranskat)abstract
- We studied the evolutionary history of the Parmeliaceae (Lecanoromycetes, Ascomycota), one of the largest families of lichen-forming fungi with complex and variable morphologies, also including several lichenicolous fungi. We assembled a six-locus data set including nuclear, mitochondrial and low-copy protein-coding genes from 293 operational taxonomic units (OTUs). The lichenicolous lifestyle originated independently three times in lichenized ancestors within Parmeliaceae, and a new generic name is introduced for one of these fungi. In all cases, the independent origins occurred c. 24 million yr ago. Further, we show that the Paleocene, Eocene and Oligocene were key periods when diversification of major lineages within Parmeliaceae occurred, with subsequent radiations occurring primarily during the Oligocene and Miocene. Our phylogenetic hypothesis supports the independent origin of lichenicolous fungi associated with climatic shifts at the Oligocene-Miocene boundary. Moreover, diversification bursts at different times may be crucial factors driving the diversification of Parmeliaceae. Additionally, our study provides novel insight into evolutionary relationships in this large and diverse family of lichen-forming ascomycetes.
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| 9. |
- Dumanski, Jan P., et al.
(författare)
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Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
- 2016
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 98:6, s. 1208-1219
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Tidskriftsartikel (refereegranskat)abstract
- Men have a shorter life expectancy compared with women but the underlying factor(s) are not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an increased risk of non-hematological tumors and that LOY could be induced by tobacco smoking. We tested here a hypothesis that men with LOY are more susceptible to AD and show that LOY is associated with AD in three independent studies of different types. In a case-control study, males with AD diagnosis had higher degree of LOY mosaicism (adjusted odds ratio = 2.80, p = 0.0184, AD events = 606). Furthermore, in two prospective studies, men with LOY at blood sampling had greater risk for incident AD diagnosis during follow-up time (hazard ratio [HR] = 6.80, 95% confidence interval [95% CI] = 2.16-21.43, AD events = 140, p = 0.0011). Thus, LOY in blood is associated with risks of both AD and cancer, suggesting a role of LOY in blood cells on disease processes in other tissues, possibly via defective immunosurveillance. As a male-specific risk factor, LOY might explain why males on average live shorter lives than females.
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