| 1. |
- Baekkeskov, S, et al.
(författare)
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Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
- 1987
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 79:3, s. 34-926
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Tidskriftsartikel (refereegranskat)abstract
- Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems to develop after a prodromal period of beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered beta-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 Mr membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 Mr immunoreactivity, at a time where a commencement of a decline in beta-cell function was detected. 64,000 Mr antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 Mr antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the Mr 64,000 human islet protein are an early marker of beta-cell autoimmunity and may be useful to predict a later development of IDDM.
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| 2. |
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| 3. |
- Ekberg, Olle, et al.
(författare)
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Radiographic findings after cricopharyngeal myotomy
- 1987
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Ingår i: Acta Radiologica. - 1600-0455. ; 28:5, s. 555-558
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Tidskriftsartikel (refereegranskat)abstract
- Single film examinations (iodine and/or barium) were reviewed in 28 patients who had undergone surgery on the cricopharyngeal muscle due to Zenker diverticula (24 patients), cricopharyngeal muscle incoordination (3 patients) and pharyngoesophageal web (one patient). All patients had had a myotomy which included the cricopharyngeal muscle and up to 3 cm of the cervical esophagus. Lateral and anterior deviation of the pharynx and cervical esophagus occurred regularly. A pharyngocutaneous fistula developed in 2 patients which healed within 3 weeks. In 5 patients there was a posterior leak of contrast medium during the first postoperative week which healed within 2 weeks. Six of these seven patients with a fistula or a leak had had either a diverticulum removed or sustained an accidental mucosal perforation. No patient had recurrence of diverticula, although, 9 patients developed a cricopharyngeal muscle impression. Iodine and barium examinations are important for monitoring early and late postoperative changes after cricopharyngeus myotomy.
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| 4. |
- Helin, I, et al.
(författare)
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Muco-epidermoid tumour of the bronchus
- 1984
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Ingår i: International Journal of Pediatric Otorhinolaryngology. - 0165-5876. ; 7:3, s. 289-295
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Tidskriftsartikel (refereegranskat)abstract
- A 7-year-old boy with recurrent pneumonia of the right lower lobe is described. At bronchoscopy a small tumour almost totally obliterating the right lower lobe was detected. Surgical treatment was undertaken. Histopathologic studies showed findings consistent with those of a muco-epidermoid tumour. The case emphasizes bronchoscopy as an important investigation in children with recurrent pneumonia. It also shows the importance of performing the bronchoscopy during a prolonged course of antibiotic prophylaxis in order to ensure a minimum of infected mucus within the bronchi. This report is completed with a short review of the literature on muco-epidermoid tumours of the bronchus in children. Their favourable prognosis and very low malignant potential is underlined.
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| 5. |
- Kaspersson, A., et al.
(författare)
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Microbial dynamics in barley grain stored under controlled atmosphere
- 1988
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Ingår i: Animal Feed Science and Technology. - : Elsevier BV. - 0377-8401 .- 1873-2216. ; 19:4, s. 299-312
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Tidskriftsartikel (refereegranskat)abstract
- Barley of 2 moisture contents, 20-23% and 26-28%, was stored airtight for 2 separate seasons in 2 full-scale silos, and for 3 separate seasons in 12-16 pilot silos (1.25 m3). The microbial dynamics were studied, using colony-forming units (CFU) of microorganisms, the proportion of internally-invaded kernels and ATP content. The ATP content was a good measure of the microbial activity, which decreased after loading and was very low during the winter period. Field-associated moulds and yeasts decreased in numbers of CFU and in the amount of invaded kernels. Fusarium species survived more satisfactorily than most field fungi. The temperature rise in spring caused an increase in ATP content, as a result of extensive growth of yeast of the genera Hansenula and Candida. This activity started earlier in the high-moisture grain (March). In May, a significant increase in CFU of Penicillium was observed and, during May to July, in many silos, all kernels were invaded, mostly by P. roqueforti. In an attempt to increase the time of safe storage, some technical improvements and gaseous and liquid chemical additives were tested. Attachment of "lungs" to the silos, and addition of organic acids or gases (CO2, N2, NH3) to the grain, increased the safe storage time by one to several months. The aerobic storage stability of rolled barley taken in July from the full-scale silos was tested. The rapid deterioration following unloading limited the aerobic storage stability to a few days. © 1988.
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| 6. |
- Lindgren, S.Å., et al.
(författare)
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Low-energy electron diffraction from close-packed Na
- 1982
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Ingår i: Journal of Physics. C, Solid State Physics. - : IOP Publishing. - 0022-3719. ; 15:30, s. 6285-6291
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Tidskriftsartikel (refereegranskat)abstract
- The authors obtain a homogeneously thick film of close-packed Na with close-packed planes parallel to the surface by evaporating Na onto Cu(111) held at LN2 temperature. Comparison between measured LEED intensity spectra, recorded at LN2 temperature, and theoretical ones, calculated under the assumption that the crystal structure of Na is FCC or HCP, favours the HCP structure. The authors UPS results indicate that if Na is evaporated onto Cu(111) held at RT, it will form three-dimensional clusters on top of a Na film only few atomic layers thick.
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| 7. |
- Lindgren, S.Å., et al.
(författare)
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Photoemission of backbonding electrons from CO chemisorbed on Cu(III)
- 1981
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 84:3, s. 487-490
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Tidskriftsartikel (refereegranskat)abstract
- Angle-resolved photoclectron energy spectra recorded in the normal direction for a CO-exposed Cu(111) sample show a peak at the Fermi edge for high monolayer coverages. We associate this peak with a filled part of a resonance-broadened CO 2π level.
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| 8. |
- Lindgren, S.Å., et al.
(författare)
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Sodium induced structure in UPS spectra of Cu(111)/Na
- 1985
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Ingår i: Surface Science. - 0039-6028 .- 1879-2758. ; 155:1, s. 165-172
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Tidskriftsartikel (refereegranskat)abstract
- UPS Spectra of sodium monolayers evaporated onto Cu(111) are presented. We interpret sodium induced structure below the Cu d-band as due to photoemitted 3d electrons which have experienced an energy loss by exciting a sodium monolayer plasmon. An experimental difficulty is that even small amounts (<1/10 monolayers) of water contamination produces structure in the same energy range. This emission is due to the OH 1π orbital. Hydroxide groups may also origin from the alkali source if this is operated at too elevated temperatures.
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| 9. |
- Lindgren, S.Å., et al.
(författare)
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Surface state energy shifts by molecular adsorption : CO on clean and Na covered Cu(111)
- 1982
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Ingår i: Surface Science. - 0039-6028 .- 1879-2758. ; 117:1-3, s. 426-433
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Tidskriftsartikel (refereegranskat)abstract
- Angle resolved photoelectron energy spectra recorded in the near UV show that the surface state 0.4 eV below EF of Cu(111) shifts to higher energy upon CO adsorption. The surface band related emission intensity is reduced by the adsorption at a rate suggesting that each adsorbed molecule wipes out the surface state over an area corresponding to seven surface layer Cu atoms. The surface state energy shift is not as closely related to the adsorbate induced workfunction change as found theoretically and experimentally for alkali adsorbates. The influence on the shift of the workfunction and initial energy of the surface state is studied by preadsorbing Na on the Cu(111) surface.
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| 10. |
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